The extinction of the Dinosaur was a tumultuous time that included some of the largest volcanic eruptions in Earth’s history, as well as the impact of a 10-15 km wide asteroid. The role these events played in the extinction of the dinosaurs has been fiercely debated over the past several decades.

New findings, published today in the journal , suggest that while massive volcanic eruptions in India contributed to Earth’s climate changes, they may not have played the major role in the extinction of dinosaurs, and the asteroid impact was the primary driver of the end-Cretaceous mass extinction.

By analysing ancient peats from Colorado and North Dakota in the USA, the researchers – led by The University of Manchester – reconstructed the average annual air temperatures in the 100,000 years leading up to the extinction.

The scientists, including from the University of Plymouth, Utrecht University in the Netherlands, and Denver Museum of Nature and Science in the USA, found that volcanic CO₂ emissions caused a slow warming of about 3°C across this period. There was also a short cold “snap” — cooling of about 5°C — that coincided with a major volcanic eruption 30,000 years before the extinction event that was likely due to volcanic sulphur emissions blocking-out sunlight.

However, temperatures returned to stable pre-cooling temperatures around 20,000 years before the mass extinction of dinosaurs, suggesting the climate disruptions from the volcanic eruptions weren’t catastrophic enough to kill them off dinosaurs.

Dr Lauren O’Connor, lead scientist and now Research Fellow at Utrecht University, said: “These volcanic eruptions and associated CO₂ emissions drove warming across the globe and the sulphur would have had drastic consequences for life on earth. But these events happened millennia before the extinction of the dinosaurs, and probably played only a small part in the extinction of dinosaurs.”

The fossil peats that the researchers analysed contain specialised cell-membrane molecules produced by bacteria. The structure of these molecules changes depending on the temperature of their environment. By analysing the composition of these molecules preserved in ancient sediments, scientists can estimate past temperatures and were able to create a detailed "temperature timeline" for the years leading up to the dinosaur extinction.

Dr Tyler Lyson, scientist at the Denver Museum of Nature and Science, said: “The field areas are ~750 km apart and both show nearly the same temperature trends, implying a global rather than local temperature signal. The trends match other temperature records from the same time period, further suggesting that the temperature patterns observed reflect broader global climate shifts.”

Bart van Dongen, Professor of Organic Geochemistry at The University of Manchester, added: “This research helps us to understand how our planet responds to major disruptions. The study provides vital insights not only into the past but could also help us find ways for how we might prepare for future climate changes or natural disasters.”

The team is now applying the same approach to reconstruct past climate at other critical periods in Earth’s history.

The Cockcroft Institute is a partnership between the Universities of Manchester, Lancaster, Liverpool, Strathclyde, and Science and Technology Facilities Council (STFC), dedicated to developing and constructing particle accelerators for pure and applied research purposes. 

The Cockcroft Institute is the national centre for accelerator research and development in the UK. It was established almost two decades ago and comprises of over 200 academics and professional accelerator staff dedicated to innovating the future of accelerator science.

The Extreme Light Infrastructure (ELI ERIC) is a research infrastructure with the world’s largest and most advanced collection of high-power, high-repetition-rate lasers. As an international user facility dedicated to multi-disciplinary science and research applications, ELI provides access to state-of-the-art technology and cutting-edge research. 

The ELI ERIC operates as a single multi-site organisation with complementary facilities specialised in different fields of research with extreme light. The Attosecond Light Pulse Source Facility (ELI ALPS), based in Hungary, is primarily aimed at realising bright, ultrafast, laser-driven secondary photon sources, driven by high-intensity, high-average power, few-cycle-pulse lasers. ELI ALPS is also developing state-of-the-art high repetition rate, laser-driven particle (electron, ion, neutron) acceleration beamlines.

The collaboration agreement targets research in laser-driven plasma acceleration, with 91ֱ�� and Lancaster providing expertise in laser-particle beam manipulation on ultra-fast (femtosecond, 10-15 second) time scales. STFC will provide insight and expertise in the control and capture of micron-size beams which are generated when laser beams with 100’s or terawatts of power interact with a plasma.

The collaboration has arisen from research undertaken by 91ֱ�� and Lancaster in laser-driven control of electron beams, including in user experiments at the ELI ALPS Facility. The agreement supports the establishment of joint PhD studentships, and a reciprocal arrangement for the exchange or hosting of PhD students, postdoctoral researchers, and ELI staff.

Professor Steven Jamison of Lancaster’s Physics Department and the Lancaster lead in the MoU, said: “This MoU is a recognition of the significant research potential that arises through the bringing together of our expertise and facility resources. It is my wish, and expectation, that through collaboration we will achieve important advances in the science and technology of generating and controlling high-energy electron beams with lasers. The technologies being targeted are revolutionary in applications such as x-ray sources and particle beams for high energy physics."

Allen Weeks, ELI ERIC Director General, added: “We are thrilled to be partnering with The Cockcroft Institute on laser-driven plasma acceleration which has broad scientific and technological applications, from high-energy physics to next-generation radiation sources. Collaborations like this are at the heart of ELI ERIC’s mission to push the boundaries of high-energy laser science while also supporting the education and training of PhD students, early career researchers and staff. These exchanges will facilitate connections and engagements between our institutes for both of our benefits.”

January

To start the year, astronomers found a mysterious object in our Milky Way. The unknown object, which was located around 40,000 light years away, is heavier than the heaviest neutron stars known and yet simultaneously lighter than the lightest black holes known. It could be the first discovery of the much-coveted radio pulsar – black hole binary

Later in the month, two University of Manchester professors,  and , were recognised in the prestigious 2024 Blavatnik Awards for Young Scientists. The pair were named among the three Laureates in recognition of their research that is transforming medicine, technology and our understanding of the world in the field of Chemical Sciences and Physical Sciences & Engineering, respectively.

February

In February, the Dalton Nuclear Institute welcomed Professor Zara Hodgson as its new Director and 91ֱ�� researchers were awarded £4.2 million funding award from UK Research and Innovation to tackle some of the UK’s most challenging resilience and security problems. 

March

March saw the Faculty of Science and Engineering’s marketing team successfully launch a new podcast, Big Sisters in STEM, which aims to amplify marginalised voices in the science, technology, engineering and mathematics (STEM) industry. Episode one was launched to more than 1000 listeners and has since been listened to in almost 60 countries. By May 2024, BSIS became the most listened podcast of The University of Manchester and is rated five stars across podcast platforms.

The University was also named an Academic Centre of Excellence (ACE-CSR) in recognition of its internationally leading cyber security research. And new research found that reduced snow cover and shifting vegetation patterns in the Alps, both driven by climate change, are having major combined impacts on biodiversity and functioning of ecosystems in the high mountains.

April

In April, Dr Dean Lomax identified the fossilised remains of what could be the largest known marine reptile. The fossilised remains measured more than two metres long and was identified as belonging to the jaws of a new species of enormous ichthyosaur, a type of prehistoric marine reptile. Estimates suggest the oceanic titan would have been more than 25 metres long.

91ֱ�� scientists also started to develop a world-first Transmission Electron Microscope (TEM) that integrates cutting-edge imaging and spectroscopy with artificial intelligence and automated workflows (AutomaTEM). The development will accelerate innovation in materials applications for quantum computing, low power electronics, and new catalysts to support the energy transition.

Also in April, six scientists in the Faculty of Science and Engineering were awarded highly prestigious European Research Council (ERC) advanced grants designed to provide outstanding research leaders with the opportunity to pursue ambitious, curiosity-driven projects that could lead to major scientific breakthroughs.

May

In May, scientists made an exciting breakthrough in quantum computing. They produced an enhanced, ultra-pure form of silicon – thought to be the world’s purest silicon  –&�Բ�����; that allows construction of high-performance qubit devices – a fundamental component required to pave the way towards scalable quantum computers. The finding could define and push forward the future of quantum computing.

Also in May, the Industrial Biotechnology Innovation Catalyst (IBIC) was launched, , Director of Jodrell Bank Centre for Astrophysics, was elected as a Fellow of the Royal Society in recognition of his “invaluable contributions to science” and scientists released the first set of scientific data captured with the Euclid telescope.

June

In June, two Professors in the Faculty were recognised in the King’s Birthday Honours.  was awarded an OBE for his services to public health, to epidemiology and to adult social care, particularly during Covid-19, while Professor Paul Howarth was awarded a CBE for his significant contribution and service to the nuclear industry and to UK research and development (R&D).

Scientists also unlocked a new design for a robot that could jump twice the height of Big Ben – higher than any other jumping robot designed to date. Applications of the robot range from planetary exploration to disaster rescue to surveillance of hazardous or inaccessible spaces.

July

July was a bumper month for health research. Scientists in the Department of Earth and Environment Sciences discovered a way to control mutation rates in bacteria, paving the way for new strategies to combat antibiotic resistance. In the Institute of Biotechnology, researchers developed a new approach to store and distribute crucial protein therapeutics without the need for fridges or freezers, significantly improve accessibility of essential protein-based drugs. They also uncovered a more efficient and sustainable way to make peptide-based medicines, showing promising effectiveness in combating cancers.

August 

During summer, scientists published findings from their study investigating triggers of explosive volcanic eruptions. For the first time, they were able to effectively simulate how bubbles grow in volcanic magma, shedding new light on one of nature’s most astonishing phenomena.

A project that aims to advance research software practices across the UK, was awarded a record £10.2 million in funding.

September

September was all about ocean waves. The M4 wave energy converter, developed by Professor Peter Stansby was successfully launched in Albany, Australia. The device is designed to harness the power of ocean waves to generate electricity, representing a significant step forward for renewable energy technology.

Scientists also discovered that ocean waves could be far more extreme and complex than previously imagined. They found that waves can reach heights four times steeper than what was once thought possible and could have implications for how offshore structures are designed, weather forecasting and climate modelling.

October

October was an exciting month as we celebrated the 20^th anniversary of graphene; the Nobel Prize-winning ‘wonder material’, which was first isolated by Professor Sir Andre Geim and Professor Sir Kostya Novoselov.

In the same month, the Department of Maths was gifted a unique mathematical object known as a  - the first known physical example of a new class of shapes called mono-monostatics. The ��ö����ö�� has the unique serial number 1824, in honour of the University’s 200^th anniversary, which has been celebrated throughout 2024.

November

In November, Professor Carly McLachlan attended a sustainability event at Buckingham Palace, hosted by King Charles III to talk about her work in sustainable live music. She attended the event as part of a delegation representing the Act 1.5 and Accelerator City initiative, alongside Robin Kemp, Head of Creative at Culture Liverpool; and four-time grammy award winning musician Nile Rodgers.

The University also partnered on two new projects – one in cyber security and one in nuclear robotics – each supported by a £5million grant by the UKRI Engineering and Physical Sciences Research Council (EPSRC) Place Based Impact Acceleration Account (PBIAA) scheme.

Ending the month, scientists unlocked the secrets of one of the most remarkable seed dispersal systems in the plant kingdom – the squirting cucumber.

December

To end the year on a high, the University’s Great Science Share for Schools was granted UNESCO Patronage for the second year in a row. Its sibling programme Engineering Educates was also endorsed by UNESCO’s Ocean Decade for its recent challenge ‘Motion in the Ocean’. And a new study from the  describes a novel biological method to convert mixed municipal waste-like fractions – including food scraps, plastics, and textiles – into valuable bio-products. 

A group of leading international scientists is calling for a global conversation about the potential creation of "mirror bacteria"—a hypothetical form of life built with biological molecules that are the opposite of those found in nature.

In a new report published today in the journal , the researchers, including Professor Patrick Cai, a world leader in synthetic genomics and biosecurity, from The University of Manchester, explain that these mirrored organisms would differ fundamentally from all known life and could pose risks to ecosystems and human health if not carefully managed.

Driven by scientific curiosity, some researchers around the world are beginning to explore the possibility of creating mirror bacteria, and although the capability to engineer such life forms is likely decades away and would require major technological breakthroughs, the researchers are calling for a broad discussion among the global research community, policymakers, research funders, industry, civil society, and the public now to ensure a safe path forward.

Professor Cai said: “While mirror bacteria are still a theoretical concept and something that we likely won’t see for a few decades, we have an opportunity here to consider and pre-empt risks before they arise.

“These bacteria could potentially evade immune defences, resist natural predators, and disrupt ecosystems. By raising awareness now, we hope to guide research in a way that prioritises safety for people, animals, and the environment."

The analysis is conducted by 38 scientists from nine countries including leading experts in immunology, plant pathology, ecology, evolutionary biology, biosecurity, and planetary sciences. The publication in is accompanied by a detailed 300-page .

The analysis concluded that mirror bacteria could broadly evade many immune defences of humans, animals, and potentially plants.

It also suggests that mirror bacteria could evade natural predators like viruses and microbes, which typically control bacterial populations. If they were to spread, these bacteria could move between different ecosystems and put humans, animals, and plants at continuous risk of infection.

The scientists emphasise that while speculative, these possibilities merit careful consideration to ensure scientific progress aligns with public safety.

Professor Cai added: “At this stage, it’s also important to clarify that some related technologies, such as mirror-image DNA and proteins, hold immense potential for advancing science and medicine. Similarly, synthetic cell research, which does not directly lead to mirror bacteria, is critical to advancing basic science. We do not recommend restricting any of these areas of research. I hope this is the starter of many discussions engaging broader communities and stakeholders soon. We look forward to hosting a forum here in 91ֱ�� in autumn 2025.”

Going forward, the researchers plan to host a series of events to scrutinise their findings and encourage open discussion about the report. For now, they recommend halting any efforts toward the creation of mirror bacteria and urge funding bodies not to support such work. They also propose examining the governance of enabling technologies to ensure they are managed responsibly.

The Hidden REF awards celebrate the impact and roles that are vital to research but are overlooked by traditional research evaluation. It aims to build a more effective and more equitable system for recognising contributions to research success.

The awards are split into five ‘output panels’ with 24 categories, each organised by output type. The panels include Applications of Research, Communicative Outputs, Context, Practices and Hidden Role.

SEERIH was Highly Commended in the Communicative Outputs panel under the category of ‘Campaigns’ for the success of its campaign, a pioneering campaign dedicated to fostering scientific curiosity and education among young learners.

The category recognises campaigns that  initiate change that is adopted across the research community and creates significant positive impact in a broad range of areas, including the way research is conducted, the diversity of the research community, the pipeline of people involved in research, or any other change that can be demonstrated to be beneficial for the research environment.

Professor Lynne Bianchi, Director of SEERIH, said: “We are very proud to have had our work recognised in this new competition across the Higher Education sector. It really does shine a light on the campaign which makes research more visible to young children, as well as empowering them to think and work scientifically themselves. We’d love for more Higher Education Institutions to get involved. I’d also like to say a special thank you to the Faculty of Science and Engineering's Kerry Wilkins for doing such a great job (as always) in supporting the application.”

and the panellists were chosen based on their experience of the submission categories.

The winners were announced at an online awards ceremony on 29 November. You can find all of the winners and re-watch the ceremony

The endorsement reinforces the programme’s significant role in inspiring scientific curiosity, inquiry, and global citizenship among young people and underscores its profound alignment with UNESCO's (United Nations Educational, Scientific and Cultural Organization) values through inclusive and equitable quality science education and promotion of sustainable lifestyles.

Now celebrating its tenth year, the pioneering initiative empowers children aged 5-14 to explore and share scientific questions they are passionate about with peers, families, and communities worldwide. Topics relate directly to the UN Sustainable Development Goals, sparking inquiry on issues such as biodiversity, carbon reduction, and sustainable practices.

In 2023-24, the GSSfS campaign reached over 670,000 pupils in more than 3,500 schools, spanning 36 countries. Of these, 50% were in areas of high socioeconomic deprivation.

Next year, the campaign seeks to be even bigger with young people responding to the theme ‘Connected Science’. Across a range of free resources teachers, pupils and whole schools are inspired to develop genuine awareness and engagement in global climate action.

James Bridge, Chief Executive and Secretary-General, UK National Commission for UNESCO, added: “We are delighted to grant UK National Commission for UNESCO Patronage to the Great Science Share for Schools campaign for a second time in 2025. Education, Science, and Communication & Information are three fundamental pillars of UNESCO’s global work, so it is great that the UK National Commission can support an initiative here in the UK that brings these together in such an imaginative and collaborative way. The GSSfS initiative aligns with UNESCO’s mandate of promoting knowledge sharing and the free flow of ideas to accelerate mutual understanding and a more perfect knowledge of each other's lives.”

SEERIH’s other campaign ‘’, has also received UNESCO endorsement of its ‘Motion in the Ocean’ challenge, which has been recognised by the (‘Ocean Decade’).  

The is a global effort to promote transformative ocean science and aim to inspire actions that will preserve ocean health for future generations.

Newly launched in September 2024, “Motion in the Ocean” is one of eight challenges within the EPSRC Robotic Autonomous Systems (RAS) Network led by The University of Manchester. This has been designed to upskill teachers and pupils (7-14 years) in applying design technology, computing and science skills to find solutions to real-world problems.

“Motion in the Ocean” introduces challenges related to ocean sustainability and marine conservation through practical applications of engineering and design.

Professor Andrew Weightman, Programme Director for RAS, said: “The new robotics theme within Engineering Educates has taken our outreach to a new level. By working with Lynne and her team we now have a much stronger focus on how our research can inspire curriculum learning. We are really delighted that we can also support the Ocean Decade.”

As extreme weather events, such as heatwaves, droughts, floods, and freezes become more common due to global heating, understanding how soil microbes – critical for healthy ecosystems – respond is crucial.

These microbes play a key role in natural processes like carbon cycling, which helps determine how much carbon is stored in the soil and how much is released into the atmosphere as carbon dioxide, a major driver of global heating.

Researchers from The University of Manchester, working with a network of scientists across Europe, collected soil samples from 30 grasslands in 10 countries. They experimentally exposed the samples to simulated extreme weather events under controlled laboratory conditions to find out how the microbes would respond.

The team found that microbial communities in soils from different parts of Europe each reacted in unique ways to the extreme events. For example, soils from cooler, wetter climates were particularly vulnerable to heatwaves and droughts, while soils from dry regions were more affected by floods.

However, the scientists also found encouraging patterns and signs of consistency. In particular, microbes that can "pause" their activity and go dormant—essentially waiting out tough conditions—in any weather condition.

The findings are published today in the journal .

, Senior Lecturer in Earth and Environment Sciences at The University of Manchester, said: “Soil microbes are vital for our ecosystems. Their ability to adapt or struggle with climate change has a direct impact on soil health, plant growth, food production and carbon storage.

“By understanding the microbes’ ‘survival strategy’, we can better predict and possibly mitigate future impacts of these extreme weather events, giving us crucial insights to safeguard vulnerable regions.

“But our research highlights just how complex and varied the effects of climate change can be. The fact that local conditions play such a huge role in how vulnerable soils are means that a "one-size-fits-all" approach won’t work when it comes to protecting soil ecosystems, suggesting tailored strategies will be key.”

Each sample site represents the diversity of biogeographic regions present in Europe: alpine (Austria), subarctic (Sweden), Arctic (Iceland), Atlantic (Oxford and Lancaster, UK), boreal (Estonia), continental (Germany), Mediterranean (Spain and GR, Greece) and steppe climate (Russia).

The research offers a key first step in predicting how microbial communities respond to climate extremes, helping inform conservation efforts and climate policies around the world.

, who conducted the research while at The University of Manchester, now a Professor of Earth Surface Science at the University of Amsterdam, added: “This study is one of the largest of its kind. By working across multiple countries and ecosystems, we have been able to provide key insights that could guide future research and environmental management strategies ensuring the health of our ecosystems in the face of increasing climate challenges.”

Formed to challenge and disrupt the global conveyor belt market, Ecobelt Ltd is an environmentally ambitious company that champions environmental sustainability and fosters a circular life-cycle approach for belting use.

In the UK alone, 4,000 tonnes of conveyor belts are incinerated or sent to landfill every week.

The ‘Sustainable Materials Innovation for Net-zero’ award recognises Ecobelt’s patented innovative belt splice technology to address the main cause of belt failure. The technology extends belt lifespan from months to years, therefore improving the upstream sustainability by reducing the demand for new belts.

Through partnership and collaboration with The University of Manchester—supported by its UKRI Impact Acceleration Account and the Sustainable Materials Innovation Hub at the Henry Royce Institute—Ecobelt tested the performance of their technology to develop an approach to repair damaged conveyor belts, employing a whole life-cycle environmental impact approach.

The judges from the Institute of Materials, Minerals & Mining commended Ecobelt’s technology, citing the robust research base and collaboration with partners as key indicators to Ecobelt’s commitment to environmental sustainability.

Conveyor belts service virtually all consumer products, production and manufacturing facilities globally, driving a market valued at $6 billion (USD) annually, fuelled by e-commerce and industry 4.0.

Despite this, the industry has been remarkably stagnant in relation to innovation, sustainability and the manufacturing process of materials used in conveyor belts. As conveyor belts are fossil fuel based, manufacturing consumes huge natural resources whilst producing significant Greenhouse Gases – an issue that Ecobelt seeks to change.

Whilst Ecobelt’s next steps for commercial scale up are still unfolding, the technology’s potential for lasting impact in the industrial settings are clear.

Professor Michael Shaver, Director of the Sustainable Materials Innovation Hub said: “Our world is driven – both literally and figuratively – by conveyor belts. Yet we don’t think of them as essential in championing 91ֱ�� as a sustainable city.

“Our eyes have been opened by this hidden gem of a local business: Ecobelt have tackled an invisible material flow that is essential to keeping our manufacturing and delivery systems moving by improving material repair, reuse and circularity. It has been a privilege to work on assessing the AnnStuMax technology and quantifying its impressive environmental credentials.”

While most plants rely on external forces such as animals, wind, or water to spread their seeds, this cucumber – scientifically known as Ecballium elaterium - launches them at high speed in a pressurised jet, sending seeds over 10 metres from the parent plant.

The fruit has long intrigued scientists for its dramatic seed dispersal method, but the exact mechanism and its benefits were poorly understood.

The new research, published in the journal , uses high-speed videography, image analysis, lab experiments and mathematical modelling to examine each phase of the ejection process.

They found that as the cucumber ripens, fluid from the fruit is squeezed into the stem, causing it to stiffen and straighten, and changing the inclination of the fruit so that it is better suited for launching seeds over long distances. The internal pressure in the fruit is so high that, once it detaches from the stem, the fluid and seeds within the shell are explosively launched in a powerful jet.

The finding has important implications for understanding the plant’s population dynamics and offers insights into evolutionary adaptations related to explosive fruit mechanisms. Its seed dispersal strategy could also inspire new technologies.

Lead researcher Finn Box from The University of Manchester, said: “Seed dispersal is incredibly important for plant survival and population, and we see a wide range of dispersal strategies across the plant kingdom, each adapted to different ecological needs.

“This research is the first comprehensive mechanical explanation for how the cucumber plant launches its seeds with remarkable speed and precision – a process almost unheard of in the plant world.

“The explosive launch of the cucumber plant has evolved over generations to help it survive. The way that the stem is able to re-position itself to the perfect angle and build enough pressure to maximise spread has been key to help regulate the plant’s population. These mechanisms allow the plant to disperse seeds over a wide area and reduce overcrowding and competition among offspring and other neighbouring plants, ensuring a better chance of survival for the next generation.”

The research could also help scientists better understand how plants might adapt to environmental changes such as temperature, rainfall patterns and soil conditions due to climate change. Effective seed dispersal plays a critical role in this adaptation as it allows them to move on and colonise new, more stable environments.

It is also thought that understanding the mechanics of explosive seed dispersal could inspire new technologies, such as smart medical devices that can eject drugs on demand and thereby increase the concentration of medication at target sites within the body.

The projects are supported through £22 million of funding – of which each will receive £5 million - by the UKRI Engineering and Physical Sciences Research Council (EPSRC) Place Based Impact Acceleration Account (PBIAA) scheme.

The first project, CyberFocus, led by Lancaster University, will strengthen and deliver strategic investments in the region’s cyber ecosystem, fuelling the potential of the North West cyber sector and keeping the UK at the forefront of advance cyber security.

Danny Dresner, Professor of Cyber Security in the Department of Computer Science and the University’s academic lead for CyberFocus, said: “The volatile, risk-filled landscape of cyber security so often gives our adversaries free rein to innovate faster than those who create for the online safety of all of us."

CyberFocus brings together the universities of Manchester, Lancaster, Salford, 91ֱ�� Metropolitan, Central Lancashire, Cumbria and Liverpool.

It will also be supported by other partners including Team Barrow (Westmorland & Furness Council, and BAE Systems), Cumbria Chamber of Commerce, Cumbria LEP, Greater 91ֱ�� Combined Authority and Lancashire County Council.

The project aims to act as a catalyst for cyber knowledge exchange across the North West, fostering a collaborative approach to research and innovation, and helping the region drive economic growth and improve cyber resilience.

CyberFocus aims to:

• Create 85 new collaborative partnerships
• Develop 400 new products, processes, or services
• Secure £40m additional funding for the region
• Train 300 individuals in cyber innovation skills

The second project, led by the UK Atomic Energy Authority, focuses on nuclear robotics and artificial intelligence. It will connect academia with the supply chain, with the aim of decommissioning the country’s nuclear legacy, as well as developing technology that can be exploited by the nuclear fusion sector.

Barry Lennox, Professor of Applied Control, in the School of Electrical and Electronic Engineering, is the University’s lead for this project.

The project will link Cumbria and Oxfordshire – its' university partners being The University of Cumbria, The University of Manchester and The University of Oxford – and hopes to mobilise significant knowledge and technology transfer between these areas.

Being the only research focused university with a research base in West Cumbria, The University of Manchester will also attempt to bring other universities into the region and support them, as they develop technology for the nuclear industry.

The project aims to:

• Create 200 business opportunities
• Establish 10 spin-out companies
• Generate 200 new jobs
• Engage 5,000 people in cluster-driven events

UK Science Minister, Lord Vallance said: “We are backing universities across the UK to home in on local strengths in research – from cybersecurity in Lancaster to maritime in Liverpool, offshore wind in Edinburgh to digital healthcare in Belfast – to support thousands of local jobs, boost skills and bring new technologies to market.

“This investment will allow innovators up and down the country to continue or expand their pioneering work to improve lives and kickstart growth in our economy with new opportunities.”

Other ongoing projects at The University of Manchester, funded by EPSRC PBIAA, include the Industrial Biotechnology Innovation Catalyst (IBIC), which is a collaborative project led by the University, aimed at creating a cohesive ecosystem for Industrial Biotechnology innovation. 

UKRI also funds the Impact Acceleration Account (IAA), which provides flexible support to progress the commercialisation and translational development of University research.

The team is a collaboration between The University of Manchester and sector partners, including BASF, Siemens, the Ogden Trust, Primary Science Teaching Trust, the Comino Foundation, the Royal Society, ASE, PSQM, SSERC, Leeds Trinity University, and CREST – involving hundreds of schools across the UK.

They won the prize in recognition of their work inspiring 5-14 years olds in practical science, through a collaborative campaign focused on pupils asking, investigating and sharing their scientific questions. Supported by their teachers, young people work scientifically to gather evidence, draw conclusions and share their learning with new audiences, from fellow pupils to community groups and dignitaries.

GSSfS is relevant to all young people, in whatever educational setting, anywhere across the world. This year, the campaign reached over 670,000 pupils in more than 3,500 schools, spanning 36 countries.

Dr Helen Pain, Chief Executive of the Royal Society of Chemistry, said: “The chemical sciences are at the forefront of tackling a range of challenges facing our world. From fundamental chemistry to cutting-edge innovations, the work that chemical scientists do has an important role to play in building our future.

“The inspiration, innovation and dedication of those who work in education is fundamental to the progress of the chemical sciences – shaping the future and setting our young people up to tackle the challenges and the opportunities facing our society and our planet.

“The team’s work demonstrates an outstanding commitment to chemistry education, and it is our honour to celebrate their considerable contribution.”

The Royal Society of Chemistry’s prizes have recognised excellence in the chemical sciences for more than 150 years. This year’s winners join a prestigious list of past winners in the RSC’s prize portfolio, 60 of whom have gone on to win Nobel Prizes for their work, including 2022 Nobel Laureate Carolyn Bertozzi and 2019 Nobel laureate John B Goodenough.

The Excellence in Education Prizes celebrate inspirational, innovative, and dedicated people working in primary, secondary, further education and higher education – including teachers, technicians and more. These prizes recognise a wide range of skills – from curriculum design to effective teaching, and from personal development to working culture. This category includes specific prizes for teams and for those in the early stages of their career.

, which aims to improve the way prosthetics for people who have suffered traumatic limb loss work, wowed the judges at the (iGEM) 2024 Grand Jamboree.

The non-profit iGEM Foundation hosts an international student competition each year to promote education and collaboration among new generations of synthetic biologists.

Human-machine interfaces are becoming more advanced, with new technologies harnessing the body’s electric signals to control devices.

Artificial limbs, known as myoelectric prosthetics, are directed by electrical signals generated by muscle contractions in the residual limb, which can be translated to motion.

However, heavy batteries and motors in myoelectric prosthetics can cause excessive sweating and make the electrodes slip from their contact points, resulting in discomfort and imprecise limb movement.

To solve the problem, the team proposed using synthetic biology to create tiny specially designed wires that work with skin cells.

They engineered a type of bacteria – Escherichia coli – to express tiny, hair-like structures known as pili (e-pili) found on electricity conducting bacteria called Geobacter sulfurreducens.

By combining the Escherichia coli with a protein-binding peptide, the team created nanowires that specifically target and bind to proteins at the skin’s surface, potentially enhancing the precision of an artificial limb.

The 91ֱ�� iGEM team were Damian Ungureanu, Devika Shenoy, Francisco Correia, Janet Xu, Jia Run Dong, Usrat Nubah, Yuliia Anisimova, and Zainab Atique-Ur-Rehman.

, said: “I’m delighted our team won gold at the iGEM 2024 Grand Jamboree for an innovation which could make a difference for people who need artificial limbs.

She added: “I have supervised the 91ֱ�� iGEM teams together with Professor Rainer Breitling since 2013.

“Our teams, based in the (MIB), have been very successful and have achieved a gold medal all but one of the years that we participated - which is quite an achievement.

“In 2016, the team also scooped the special award for ‘Best Computational Model’ and were shortlisted for the ‘Best Education and Public Engagement’ award.”

This year’s 91ֱ�� iGEM team worked in the MIB labs throughout the summer, with financial and logistical support from the MIB, School of Biological Sciences, School of Social Sciences/Department of Social Anthropology, School of Arts Languages and Cultures, and the Future Biomanufacturing Research Hub.

The team also worked with the (AMBS) to comprehensively explore the social and economic implications of their ideas using a (RRI) approach.

The competition provides an interdisciplinary learning opportunity for students outside biology, by encouraging participants to think beyond their lab work.

Damian Ungureanu, second year Biochemistry student, said: “Working with people from different cultural and academic backgrounds has allowed me to substantially develop my communication skills. Even though this was a synthetic biology project, the human practices aspect was just as important as the science. Winning the gold medal felt like the culmination of one year of hard work.”

Devika Shenoy, second year Biomedical Sciences student, said: “I am grateful to have gotten the opportunity to work with so many like-minded individuals and under the guidance of skilled advisors and PIs. iGEM has truly broadened my horizons and understanding of how science and synthetic biology can be used to solve world issues.”

The lecture, which celebrates the significant contributions made by women to the study of the Natural Sciences, was delivered in collaboration with the prestigious Linnean Society of London.

Hosted by Dr Maggy Fostier, Faculty Associate Dean for Environmental Sustainability, Professor Bamford took the audience on a journey from her industrial roots in Essex to her conservation work in Costa Rica and Panama, offering insight into the world of plant science and environmental issues like climate change along the way.

She described how her childhood interest in botany had been inspired by wild orchids growing in an abandoned chalk quarry in her local area in Essex. Her passion for plants and wildlife eventually led her to conservation work in Central America, where she has helped protect critically endangered amphibian and bird species from extinction.

She said: “It was a great honour to give the 2024 Irene Manton lecture. I wanted to show the importance of taking every opportunity to engage with wildlife and conservation, even in an abandoned chalk quarry reclaimed by nature, and the importance of connecting with people and their communities in order to conserve  endangered species."

Taking place at 91ֱ�� Museum, Professor Bamford’s lecture attracted an audience of academics, conservation enthusiasts, and students from local schools and colleges.

Robbie Blackhall-Miles, former Vice-President of the Linnean Society, also told the gathering that British botanist Irene Manton studied for her PhD at the University of Manchester and went on to an influential career which included becoming the first female President of the Linnean Society.

Amanda was joined by Matt O’Donnell, the Museum’s Curator of Herpetology, who spoke about his own work as a frog conservationist. He carries out  important frog research and conservation projects in Costa Rica. He also brought along some particularly popular contributors – several live tropical frogs from the Museum’s vivarium!

With the aim of the lecture being to encourage young people to explore a career in the natural sciences, Professor Bamford’s story demonstrated the impact conservation work can have on animals, plants, and the humans who protect them.

Professor Carly McLachlan, Director of Manchester Tyndall Centre for Climate Change Research, was among a group of government officials, business leaders and climate organisations at the exclusive conference hosted by King Charles III.

The reception, on 6 November, aimed to accelerate climate action before the UN climate change conference Cop29.

Professor McLachlan represented the University’s collaboration with Act 1.5, an artist-led research and action initiative incepted by the band Massive Attack to address carbon reduction within live music. Act 1.5 works closely with climate scientists at the , with its name referencing the goal of keeping global temperature rises below 1.5°C, in line with the Paris Agreement.

At the event Professor McLachlan and the team had the opportunity to discuss their project to the UK’s climate leaders, highlighting how the live music industry can play a pivotal role in reducing carbon emissions and inspiring sustainable practices across the entertainment sector and beyond.

Following several years of developmental work by Act 1.5 in collaboration with the Tyndall Centre at The University of Manchester, the city of Liverpool was recently named the . The city will become a testing ground for innovative ideas and climate strategies in music, film, and television.

The initiative will officially launch later this month in Liverpool with three nights of live performances and a two-day conference, one for industry and one for the public, dedicated to exploring sustainable practices in the live entertainment sector.

It builds on a commissioned by the band Massive Attack to produce what is anticipated to have been the lowest greenhouse gas emissions show of its size ever staged.

After a year, the Accelerator status will be passed to another global city. The University’s researchers will work with various ‘experiments’ across the Liverpool City Region to capture and synthesise the insights gained from Liverpool’s experiences to inform the next Accelerator City.

The Act 1.5 and Accelerator City initiative were represented by Robin Kemp, Head of Creative at Culture Liverpool; and musician Nile Rodgers, alongside Professor McLachlan at the Buckingham Palace Reception. Four-time Grammy Award winner Nile Rodgers will play one of the three nights of shows in Liverpool later this month.

Biocatalysis is a process that uses enzymes as natural catalysts to carry out chemical reactions. Scientists at The University of Manchester and AstraZeneca have developed a new biocatalytic pathway that uses enzymes to produce nucleoside analogues, which are vital components in many pharmaceuticals used to treat conditions like cancer and viral infections.

Typically, producing these analogues is complicated, time consuming and generates significant waste. However, in a new breakthrough, published in the journal , the researchers have demonstrated how a "biocatalytic cascade" — a sequence of enzyme-driven reactions — can simplify the process, potentially cutting down production time and reducing environmental impact.

The researchers engineered an enzyme called deoxyribose-5-phosphate aldolase, enhancing its range of functions to efficiently produce different sugar-based compounds, which serve as building blocks for nucleoside-based medicines, such as oligonucleotide therapeutics. These building blocks were combined using additional enzymes to develop a condensed protocol for the synthesis of nucleoside analogues which simplifies the traditional multi-step process to just two or three stages, significantly improving efficiency.

With further refinement, this method could help streamline the production of a wide range of medicines, while significantly reducing their environmental footprint. The team are now continuing this work with the MRC funded , which looks to develop sustainable biocatalytic routes towards functionalised nucleosides, nucleotides and oligonucleotides.

The study, led by scientists at The University of Manchester, has revealed that a material known as a metal-organic framework (MOF) - an ultra-porous material - can be modified to capture and filter out significantly more benzene from the atmosphere than current materials in use.

Benzene is primarily used as an industrial solvent and in the production of various chemicals, plastics, and synthetic fibres, but can also be released into the atmosphere through petrol stations, exhaust fumes and cigarette smoke. Despite its widespread applications, benzene is classified as a human carcinogen, and exposure can lead to serious health effects, making careful management and regulation essential.

The research, published in the journal today, could lead to significant improvements in air quality both indoors and outdoors.

MOFs are advanced materials that combine metal centres and organic molecules to create porous structures. They have a highly adjustable internal structure, making them particularly promising for filtering out harmful gases from the air.

The researchers modified the MOF structure – known as MIL-125 – by incorporating single atoms from different elements, including zinc, iron, cobalt, nickel and copper to test which would most effectively capture benzene.

They discovered that adding a single zinc atom to the structure significantly enhanced the material’s efficiency, enabling it to capture benzene even at ultra-low concentrations – measured at parts per million (ppm) – a significant improvement over current materials.

The new material – now known as MIL-125-Zn – demonstrates a benzene uptake of 7.63 mmol per gram of material, which is significantly higher than previously reported materials.

It is also highly stable even when exposed to moisture, maintaining its ability to filter benzene for long periods without losing effectiveness. Tests show that it can continue removing benzene from air even under humid conditions.

As the research progresses, the team will look to collaborate with industry partners to develop this and related new materials, with the potential of integrating it into ready-made devices, such as air purification systems in homes, workplaces, and industrial settings.

Plastics play a crucial role in healthcare, but the current linear model of using and then incinerating leads to significant waste and environmental harm. Through a Knowledge Transfer Partnership (KTP), materials experts at 91ֱ�� will work in collaboration with Vernacare – specialist manufacturers of infection prevention solutions – to investigate how the sustainability of plastics can be improved through the creation of more circular products from waste polypropylene (PP) and polycarbonate (PC).  

A 24-month project, led by an interdisciplinary team from The University of Manchester and Vernacare, aims to create new insight into the behaviour of real-world polypropylene and polycarbonate products during mechanical recycling. The team will be led by experts including Dr Tom McDonald, Dr Rosa Cuellar Franca, Professor Mike Shaver, Simon Hogg, and Dr Amir Bolouri. It also will advance knowledge on the selection, characterisation and use of plastic to optimise recyclability, while developing understanding of the complex environmental impacts of product design and supply chain. 

Finally, life cycle assessment will be used to evaluate the sustainability for different approaches to the circularity of these plastics. This project will involve the knowledge transfer of the academic team’s expertise in plastics recycling, plastics circularity and rigorous life cycle assessment. 

Alex Hodges, CEO of Vernacare, explained: “Through this project we aim to change how plastics are viewed and used in healthcare. Our work with 91ֱ�� will ensure we’re at the forefront in sustainable single use healthcare product research. It will enable us to embed product lifecycle, environment assessment capability and materials research and development into our business culture so that we’re in pole position, able to lead the market in the development and testing of future solutions. It will also help Vernacare economically, by offsetting a portion of our £7m annual polypropylene costs while also broadening their appeal to eco-conscious customers.” 

The research will be conducted through the (SMI Hub), a cutting-edge facility dedicated to sustainable plastic solutions. The SMI Hub is part of the Henry Royce Institute at The University of Manchester and is partly funded by the European Regional Development Fund.                                                                                           

Innovate UK’s Knowledge Transfer Partnerships  funding support innovation by matching businesses with world-leading research and technology. Projects are focused on delivering a strategic step change in productivity, market share and operating process by embedding new knowledge and capabilities within an organisation. Delivered through the Knowledge Exchange Partnerships team, part of Business Engagement and Knowledge Exchange, The University of Manchester has collaborated on more than 300 KTPs and in the last five years alone, has supported 42 KTPs with a total research value of £11 million. 

By working together, The University of Manchester and Vernacare aim to lead the way in sustainable healthcare products, ensuring a healthier planet for future generations. 

If you are interested in applying for the Eli & Britt Harari Award 2025, here are the details:

• Applications open: Monday 11th November 2024
• Applicant Support Session: Tuesday 28th January 2025
• Applications close: Monday 10th February 2025
• Find out more information, head to the Award's page on the MEC website .
• Any questions: Contact harari@manchester.ac.uk

Although scientists knew one atom thick, two-dimensional crystal graphene existed, no-one had figured out how to extract it from graphite, until Professor Geim and Professor Novoselov’s groundbreaking work in 91ֱ�� in 2004.

Geim and Novoselov frequently held ‘Friday night experiments’, where they would play around with ideas and experiments that weren’t necessarily linked to their usual research. It was through these experiments that the two first isolated graphene, by using sticky tape to peel off thin flakes of graphite, ushering in a new era of material science.

Their seminal paper ‘, has since been cited over 40,000 times, making it one of the most highly referenced scientific papers of all time.

What Andre and Kostya had achieved was a profound breakthrough, which would not only earn the pair a Nobel Prize in 2010 but would revolutionise the scientific world.

The vast number of products, processes and industries for which graphene could significantly impact all stem from its extraordinary properties. No other material has the breadth of superlatives that graphene boasts:

• It is many times stronger than steel, yet incredibly lightweight and flexible
• It is electrically and thermally conductive but also transparent
• It is the world’s first two-dimensional material and is one million times thinner than the diameter of a single human hair.

It’s areas for application are endless: transport, medicine, electronics, energy, defence, desalination, are all being transformed by graphene research.

In biomedical technology, graphene’s unique properties allow for groundbreaking biomedical applications, such as targeted drug delivery and DIY health-testing kits. In sport, graphene-enhanced running shoes deliver more grip, durability and 25% greater energy return than standard running trainers – as well as the world’s first .

Speaking at the , hosted by The University of Manchester, Professor Sir Andre Geim said: “If you have an electric car, graphene is there. If you are talking about flexible, transparent and wearable electronics, graphene-like materials have a good chance of being there. Graphene is also in lithium ion batteries as it improves these batteries by 1 or 2 per cent.”

The excitement, interest and ambition surrounding the material has created a ‘graphene economy’, which is increasingly driven by the challenge to tackle climate change, and for global economies to achieve zero carbon.

At the heart of this economy is The University of Manchester, which has built a model research and innovation community, with graphene at its core. The enables academics and their industrial partners to work together on new applications of graphene and other 2D materials, while the accelerates lab-market development, supporting more than 50 spin-outs and numerous new technologies.

Professor James Baker,  CEO of Graphene@91ֱ�� said: “As we enter the 20^th anniversary since the first discovery of graphene, we are now seeing a real ‘tipping point’ in the commercialisation of products and applications, with many products now in the market or close to entering. We are also witnessing a whole new eco-system of businesses starting to scale up their products and applications, many of which are based in 91ֱ��."

What about the next 20 years?

The next 20 years promise even greater discoveries and The University of Manchester remains at the forefront of exploring the limitless graphene yields.

Currently, researchers working with INBRAIN Neuroelectronics, with funding from the European Commission’s Graphene Flagship, are developing brain implants from graphene which could enable precision surgery for diseases such as cancer.

Researchers have also developed wearable sensors, based on a 2D material called hexagonal boron nitride (h-BN), which have the potential to change the way respiratory health is monitored.

As for sustainability, Dr Qian Yang is using nanocapillaries made from graphene that could lead to the development of a brand-new form of , while others are looking into Graphene’s potential in grid applications and storing wind or solar power. Graphene is also being used to reinforce , to reduce cement use – one of the leading causes of global carbon dioxide.

Newly-appointed Royal Academy of Engineering Research Chair, Professor Rahul Nair, is investigating graphene-based membranes that can be used as water filters and could transform access to clean drinking water.

Speaking at the World Academic Summit, Professor Sir Andre Geim said: “Thousands of people are trying to understand how it works. I would not be surprised if graphene gets another Nobel prize or two given there are so many people who believe in this area of research.”

Discover more

To hear Andre’s story, including how he and Kostya discovered the wonder material in a Friday night lab session, visit: 

To find out more about The University of Manchester’s work on graphene, visit: 

To discover our world-leading research centre, or commercial accelerator, visit

To find out how we’re training the next generation of 2D material scientists and engineers, visit:

• .

The new Hub for Advanced Long-acting Therapeutics (HALo) will focus on driving research, public and patient engagement, and the translational infrastructure required for the development and manufacture of new Long-acting therapeutics (LATs).

LATs are predicted to revolutionise treatment of health conditions by replacing extensive periods of daily pill taking with a single administered dose.

The approach addresses the issue of missed daily drug doses, which can cause a range of complications, from a lack of efficacy to pathogen resistance. They will also help patients stay on treatment, make it easier to achieve optimal dosing targets and reduce the burden on health systems.

The project is supported with an £11 million grant from the Engineering and Physical Sciences Research Council (EPSRC). As a key partner, The University of Manchester has been awarded £1.5m from the grant to lead efforts to advance multiple strands of LAT research.

The 91ֱ�� activity is an interdisciplinary team, led by , Reader in Sustainable Materials. Dr McDonald is Head of Environmental Sustainability and Engagement for the and is also Research Area lead for Chemical Materials Design within the .  

Alongside Dr McDonald is , , and .

The 91ֱ�� team will focus on:

• Developing innovative in situ forming implant technologies, which allow for a controlled release of medication directly at the site of need.
• Creating predictive models to evaluate drug release kinetics, helping to optimise LAT formulations for better patient outcomes.
• Quantifying the sustainability benefits of LAT medicines, including reductions in packaging waste and resource use, as part of a broader effort to make healthcare more environmentally friendly.

Dr Tom McDonald said: “Long-acting therapeutics have the potential to address significant challenges in drug administration by offering more convenient, effective, and sustained treatment options.”

LATs are emerging as the next landmark for healthcare management; pharmaceutical companies are realising the benefits for clinical outcomes and patient well-being. Such technologies are already in use in fields such as contraception, HIV therapy, and the management of mental health conditions.

By focusing on understanding the physical science that underpins existing successful LAT medicines, HALo will create new proof-of-concept LAT medicine candidates for diseases and conditions where no LAT option exists yet, such as high blood pressure and asthma.

HALo is led by Professor Steve Rannard at the and the Hub will primarily be hosted within its Centre of Excellence for Long-acting Therapeutics (CELT) - the world’s first academic centre of excellence focussed on LATs.

Professor Rannard said: “Long-acting therapeutics have the potential to simplify the administration of medicines, improve clinical outcomes and reduce the costs of healthcare provision.

“They are widely predicted to revolutionise disease treatment and healthcare management. HALo provides a much-needed focal point for new LAT developments in the UK and by working with partners it will ensure the UK is on the path to global leadership in this exciting new field.

“The outcomes from HALo will have far-reaching benefits globally and also enable CELT focus on low and middle-income country healthcare needs where LATs are expected to be transformational.”

HALo brings together academics, industry, clinicians and other stakeholders including patient groups and policy makers. Key partners of the project, include The University of Manchester, Queens University Belfast, the University of Nottingham, alongside the Liverpool University Hospitals Foundation Trust, Alder Hey Children’s Foundation Trust and the Liverpool School of Tropical Medicine.

HALo is one of  that aim to transform healthcare through the development and application of revolutionary new technologies.

The Moon, like the Earth, has been bombarded by asteroids and comets since its formation, leaving behind craters and basins. However, the exact timing and intensity of most of these events, notably the oldest and largest basin on the Moon, have remained unclear to scientists—until now.

By analysing a lunar meteorite known as Northwest Africa 2995, a team led by scientists at The University of Manchester have investigated the age of the formation of the massive South Pole-Aitken (SPA) basin – the Moon’s oldest confirmed impact site, which is located on the far side of the Moon and stretches more than 2,000 kilometres.

The proposed date is around 120 million years earlier than what is believed to be the most intense period of impact bombardment on the Moon.

The finding, published today in , provides a clearer picture of the Moon’s early impact history.

, Royal Society University Research Fellow at The University of Manchester, said: “Over many years scientists across the globe have been studying rocks collected during the Apollo, Luna, and Chang’e 5 missions, as well as lunar meteorites, and have built up a picture of when these impact events occurred.

“For several decades there has been general agreement that the most intense period of impact bombardment was concentrated between 4.2-3.8 billion years ago - in the first half a billion years of the Moon’s history.  But now, constraining the age of the South-Pole Aitken basin to 120 million years earlier weakens the argument for this narrow period of impact bombardment on the Moon and instead indicates there was a more gradual process of impacts over a longer period.”

The Northwest Africa 2995 meteorite was found in Algeria in 2005 and is what geologists refer to as a regolith breccia, which means it contains fragments of different rock types that were once a lunar soil and have been fused together by the heat and pressure involved in an impact event.

By analysing the amount of uranium and lead found in a range of mineral and rock fragments within the meteorite, the researchers were able to determine the materials dated back to between 4.32 and 4.33 billion years ago.

The team, which included The University of Manchester, the Institute of Geology and Geophysics – Chinese Academy of Sciences in Beijing, the Swedish Museum of Natural History in Stockholm, and the University of Portsmouth, then compared these results to data collected by NASA’s Lunar Prospector mission, which orbited the Moon studying its surface composition between 1998 and 1999. The comparison revealed many chemical similarities between the meteorite and the rocks within the SPA basin, confirming their link and enabling the new age estimate.

, Senior Lecturer at The University of Manchester, said: “The implications of our findings reach far beyond the Moon. We know that the Earth and the Moon likely experienced similar impacts during their early history, but rock records from the Earth have been lost. We can use what we have learnt about the Moon to provide us with clues about the conditions on Earth during the same period of time.”

This new understanding opens new avenues for future lunar exploration.

from The University of Manchester, said: “The proposed ancient 4.32 billion year old age of the South Pole-Aiken basin now needs to be tested by sample return missions collecting rocks from known localities within the crater itself.”

Organised by , the workshop provided an engaging platform for sharing the latest advancements in SF₆ leak mitigation, lifecycle management of SF₆ alternatives, retrofill replacement interventions, and new applications for high-voltage systems. The event featured insightful presentations from industry leaders, including Hitachi Energy, GE Vernova and Siemens Energy, and concluded with closing remarks from NGET.

Attendees were offered technical tours of the National Graphene Institute and High Voltage Laboratory, showcasing state-of-the-art research facilities. The event included representatives from network utilities across Great Britain, Ireland and France, fostering collaboration and knowledge exchange.

The workshop demonstrated the commitment of key industry players to advance SF₆ alternatives and pave the way for more sustainable power systems in the future.

Led by Professor Deborah Greaves at the University of Plymouth, the Supergen ORE Hub includes co-directors from a consortium of ten universities. From The University of Manchester, serves as a Co-Director and is an Early Career Researcher (ECR) Co-Lead.

The report, aimed at researchers, industry, policymakers, and the public, summarises the current impacts of climate change and the UK’s progress in reducing carbon emissions. It outlines offshore renewable energy deployment pathways needed for a just, sustainable and secure energy transition, with 2040 identified as a key milestone towards the UK 2050 Net Zero goals.

Key findings from the report include:

• Achieving 100 GW of offshore wind energy by 2040 is critical, requiring a nearly seven times increase in capacity. Radical innovation is essential to optimise and scale up growth.
• Tidal stream energy has the potential to grow alongside offshore wind and could reach over 11 GW of capacity in UK waters. Rapid progress is required, to deliver the EU SET Plan target of 6 GW deployment of tidal stream by 2050.
• Wave energy has significant potential, with an estimated exploitable resource of 25 GW in the UK. Deployment of 12 GW of wave and tidal stream by 2050 could add £40 billion GVA to the UK economy and reduce energy balancing costs by £1 billion annually. Investment in innovation over the next decade is crucial to achieving this potential.

Professor Tim Stallard said: “The ORE Outlook 2040 report highlights the high potential for Offshore Renewable Energy sources to contribute to the UK meeting its Net Zero goals. The growth required cannot be realised by upscaling current approaches alone and urgent action is needed to accelerate innovation and deployment.”

The report also explores ORE development through lenses of planning and consenting, people, supply chain, and infrastructure and grid. Investment in research and innovation is highlighted as crucial to de-risking new technologies, reducing costs, improving performance and ensuring the UK retains its technological leadership on the global stage.

The Supergen ORE Hub, established by the Engineering and Physical Sciences Research Council (EPSRC), aims to deliver strategic and coordinated research on sustainable power generation and supply.

The Astrophysics Centre for Multi-messenger Studies in Europe (ACME), funded by the European Union and coordinated by Centre national de la recherche scientifique (CNRS), is an ambitious initiative that is designed to provide seamless access to instruments, data and expertise, focussing on the new science of multi-messenger astrophysics.

Multi-messenger astrophysics is a relatively new but rapidly growing field that uses information from various cosmic signals, such as photons, gravitational waves, neutrinos, and cosmic rays, to study some of the most extreme and mysterious phenomena in the Universe like  black hole mergers, neutron star collisions, and supernova explosions. Combining data from multiple sources – or messengers – offers a more comprehensive understanding than traditional astronomy alone.

The ACME will bring together 40 leading institutions from 15 countries, including The University of Manchester’s and aims to forge a basis for strengthened long-term collaboration between these research infrastructures irrespective of location and level-up access opportunities across Europe and beyond.

The , which The University of Manchester operates on behalf of the Science and Technology Facilities Council, and expertise from the will play a crucial role in facilitating these goals.

Professor Rob Beswick from The University of Manchester, who co-leads ACME’s transnational access programme, said: “ACME is an incredibly exciting opportunity. This project will bring together a wide range of world-class researchers and astronomical research infrastructure spanning astroparticle and gravitational wave facilities along the entire electromagnetic spectrum, with a common focus to advance multi-messenger astrophysics,” 

The AMCE project will be coordinated by Prof Antoine Kouchner (CNRS/Université Paris Cite) and Paolo D’Avanzo (INAF). A key element of the project is to develop six new multi-messenger Centres of Excellence across Europe, which will serve as hubs of expertise for all researchers in all aspects of direct and multi-messenger science programmes, providing support from proposals to data analysis and science interpretation.

, who leads JBCA’s involvement in these new Centres of Excellence says “The ACME project will bring many infrastructures and groups together across Europe in a unique collaboration to provide the astronomy and astroparticle communities unprecedented access to data, workflows and expertise. ACME will revolutionise how researchers in multi-messenger fields work and collaborate in the future.”

ACME officially launched in September 2024 at a kick-off meeting held in Paris.

The Nature Genetics communication , published today (02/10/24), has shown that around a year with rare genetic diseases never receive a diagnosis, many dying without the underlying cause being determined.

The researchers also emphasise existing research that calculates the of pursuing lengthy diagnostic journeys rare genetic diseases to the NHS is over £3 billion per decade. 

Hospital geneticists rely on published evidence to make diagnoses, but because of inconsistent variant naming, say the authors, they are often unable to locate relevant information, even if it exists. 

Many geneticists, they say, are using simpler but less accurate nomenclature, preventing databases like ClinVar and the Leiden Open Variation Database (LOVD) from properly identifying and adding literature to their records. 

However, a system called devised by researchers at the University of Leicester and now based at The University of Manchester is being used by leading medical journals to give each variant a standardized name.  That allows diagnostic evidence to be shared and found. 

In the communication paper the authors urge doctors to use the system to name genetic variants.

Though rare diseases, caused by variations in DNA sequences, affect fewer than 1 in 2,000 people the sheer number of rare genetic disorders at around 8,000 impact about 8%-10% of births worldwide.

Lead author Dr Peter Freeman from The University of Manchester, whose son has an undiagnosed genetic disorder, is lead scientist in the team that devised and develop VariantValidator.

He said: “It’s widely recognized that doctors often describe DNA variants using various outdated or non-standard naming systems.

“But the accurate naming of variants is crucial so that doctors can reference them and provide a diagnosis for patients with a genetic disorder.

“Sadly, many people, including my son, have not received the diagnosis they need which has difficult implications for them.

“For example without a diagnosis it can be very difficult to get a place at an appropriate school, or access desperately needed services.

“It’s galling to know that someone out there might have identified the variant which caused his illness, but may not have named it correctly so there’s no way of finding it.”

He added: “VariantValidator has been around for 7 years and is considered the gold standard in terms of naming genetic variants accurately so other clinicians will be able to find the definition and use them.

“But in a vast number of cases that is just not happening because it’s easier and quicker to cut corners or rely on outdated systems only recognisable in specific clinical disciplines.

“The problem is so widespread I’ve even come across experts responsible for setting clinical standards making these errors when naming variants in genetics focussed policy guidelines”.

“Our work is with the Human genome, but the nomenclature of genetic variants in viruses and other pathogens are also similarly non-standardised - and that’s also a problem which needs to be addressed.

“Nomenclature should accurately describe the changes in DNA sequencing observed when there is a variant when compared to a standard sequence. But in many cases, this is simply not happening and is part of a complex set of problems that is causing miss or missed diagnoses.”

The paper Standardising variant naming in literature with VariantValidator to increase diagnostic rates is available

The Centre for Innovative Recycling and Circular Economy (CIRCLE) UK team will be led by Dr , Reader is Sustainable Biotechnology at the 91ֱ�� Institute of Biotechnology, alongside a team of international academics. Also part of the project are Professors and , and Drs , and Micaela Chacon.

CIRCLE aims to address the global challenge of anthropogenic waste by closing the loop and using it as a feedstock for the chemicals industry. Much of the waste produced by society is a rich source of carbon, a building block for many important chemicals and materials found in everyday products such as plastics, personal care products, and pharmaceuticals. CIRCLE will identify and employ novel biotechnological processes to break down this waste into its chemical components and avoid the need for virgin petrochemical feedstocks.

This project will bring together academic expertise from across the globe, including the US, Canada and South Korea.

The 2024 Global Centres awards focus on advancing bioeconomy research to solve global challenges, whether by increasing crop resilience, converting plant matter or other biomass into fuel, or paving the way for biofoundries to scale-up applications of biotechnology for societal benefit.  The programme supports holistic, multidisciplinary projects that bring together international teams and scientific disciplines, including education and social sciences, necessary to achieve use-inspired outcomes. All Global Centres will integrate public engagement and workforce development, paying close attention to impacts on communities.

“Alongside replacing fossil fuels, there is an urgent need to replace petrochemical industrial feedstocks across a wide range of sectors. This is a global challenge that requires global solutions and UKRI is delighted to be partnering in the NSF Global Centres 2024 programme to meet this need”, said UKRI CEO, Professor Dame Ottoline Leyser. “The announcement today will be at the forefront of real-world solutions, from improved recycling to new bioplastics, building a sustainable circular economy. The centres will create the global networks and skills needed to drive a thriving bioeconomy benefitting all.”

The rankings are determined by scholars’ H-index, a metric evaluating productivity and citation impact, following examination of over 166,000 profiles across all key scientific disciplines.

, Emeritus Professor of Rheumatology and Musculoskeletal Epidemiology at the University, placed 29^th in this year’s list with a H-index score of 122 and 82,294 citations.

Deborah said of the recognition: “I retired and published my last paper in 2016. It is pleasing to find that the cumulative citation of my research leads to this high ranking and I hope that gives encouragement to those who are currently working in the field of musculoskeletal epidemiology.”

, Emeritus Professor of Physiology and former President and Vice-Chancellor of The University of Manchester, placed 37^th on the list with 49,760 citations and a H-index of 119.

In 79^th position in this year’s ranking is , Emeritus Professor of Evidence Based Care, with a H-index of 105 and 46,311 citations.

Helen said of the achievement: “I have spent my career collaborating with, and supporting, many extremely talented female researchers, and I feel that my success has only been enhanced through these positive working relationships. I jointly led Cochrane Oral Health until 2020, developing a team that continues to undertake methodologically rigorous systematic reviews that inform policy in areas of international policy.

“I have also been responsible for the design of several NIHR funded randomised controlled trials in dental primary care. The reviews and trials I have collaborated on frequently challenged orthodox care and impacted on the global understanding of effective oral health interventions and practices.”

This year’s ranking, the third instalment of the list to date, is based on data from a variety of sources including OpenAlex and CrossRef.

The Albany M4 project, led by Professor Christophe Gaudin and Dr. Hugh Wolgamot, and coordinated by Dr. Wiebke Eberling of the University of Western Australia, aims to explore the potential of wave energy to support local decarbonisation efforts along Australia’s Great Southern coast. The launch is a quarter-scale demonstration model designed specifically for this application and will absorb 1-10kW in the target sea-states. Sensors on the model will provide real-time data on energy production and performance.

The M4 project is fully open-access with all data collected during the device’s deployment being made available to scientists, developers, and the public. By making the performance data accessible to all, the project aims to drive further innovation in renewable energy.

The M4, or Moored Multi-Mode Multibody, is an innovative surface-riding wave energy converter consisting of multiple floats, connected by beams, in a 1-2-1 float arrangement for the Albany tests. The middle floats each support a hinge, and relative rotation between the bow and stern floats, due to the movement of the waves, creates power in a generator. It uses a single mooring point that allows the M4 to naturally turn and face the waves for better energy capture.

The M4 highlights 91ֱ��’s leading role in renewable energy innovation and has been developed over the past decade with support from the Engineering and Physical Sciences Research Council (EPSRC) and the European Union. British Maritime Technology (BMT) was responsible for the structural and mooring design for Albany, while the power take-off (PTO) design was led by Dr Judith Apsley from The University of Manchester’s Department of Electrical and Electronic Engineering, and further developed with the support of Dr Nuwantha Fernando at RMIT University, Melbourne.

The launch, funded with 4.8 million AUD from the WA state government and the Blue Economy Cooporative Research Centre, with similar in-kind contributions, also showcases the wider benefits of emerging renewable technologies, with six local contractors and manufacturers contributing to the building, assembling, deploying, and decommissioning of the device in Albany.

The University of Manchester’s Hydrodynamics Lab played a key role in the development of the M4. Located in the heart of Manchester, this state-of-the-art facility allows researchers to simulate ocean conditions and test renewable energy designs. 

Professor Peter Stansby highlighted its importance, stating: “The Hydrodynamics Lab is vital for advancing renewable energy research. While computational modelling provides valuable predictions, experimental validation is essential for understanding and optimising complex systems.”

For more information about The University of Manchester’s contributions to offshore renewable energy systems visit our webpage.

The new study, published in today, reveals that under specific conditions, where waves meet each other from different directions, waves can reach heights four times steeper than what was once thought possible.

It has often been assumed that waves are two-dimensional and understanding of wave breaking to-date has been based on these assumptions. Yet in the ocean, waves can travel in many directions and rarely fit this simplified model.

New insights by a team of researchers, including Dr Samuel Draycott from The University of Manchester and Dr Mark McAllister from the University of Oxford, reveal that three-dimensional waves, which have more complex, multidirectional movements, can be twice as steep before breaking compared to conventional two-dimensional waves, and even more surprisingly, continue to grow even steeper even after breaking has occurred.

The findings could have implications for how offshore structures are designed, weather forecasting and climate modelling, while also affecting our fundamental understanding of several ocean processes.

Professor Ton van den Bremer, a researcher from TU Delft, says the phenomenon is unprecedented: “Once a conventional wave breaks, it forms a white cap, and there is no way back. But when a wave with a high directional spreading breaks, it can keep growing.”

Three-dimensional waves occur due to waves propagating in different directions. The extreme form of this is when wave systems are “crossing”, which occurs in situations where wave system meet or where winds suddenly change direction, such as during a hurricane. The more spread out the directions of these waves, the larger the resulting wave can become.

,  Senior Lecturer in Ocean Engineering at The University of Manchester, said: “We show that in these directional conditions, waves can far exceed the commonly assumed upper limit before they break. Unlike unidirectional (2D) waves, multidirectional waves can become twice as large before they break.”

Professor Frederic Dias of University College Dublin and ENS Paris-Saclay, added: “Whether we want it or not, water waves are more often three-dimensional than two-dimensional in the real world. In 3D, there are more ways in which waves can break.”

Current design and safety features of marine structures are based on a standard 2D wave model and the findings could suggest a review of these structures to account for the more complex and extreme behaviour of 3D waves.

Dr Mark McAllister from the University of Oxford and Wood Thilsted Partners said: “The three-dimensionality of waves is often overlooked in the design of offshore wind turbines and other marine structures in general, our findings suggest that this could lead to underestimation of extreme wave heights and potentially designs that are less reliable.”

The findings could also impact our fundamental understanding of several ocean processes.

Dr Draycott said: “Wave breaking plays a pivotal role in air-sea exchange including the absorption of C0₂, whilst also affecting the transport of particulate matter in the oceans including phytoplankton and microplastics.”

The project follows on previous research, , to fully for the first time ever at the the at the University of Edinburgh. Now, the team have developed a new 3D wave measurement technique to study breaking waves more closely.

The FloWave wave basin is a circular multidirectional wave and current simulation tank, which is uniquely suited to the generation of waves from multiple directions.  

Dr Thomas Davey, Principal Experimental Officer of FloWave, at the University of Edinburgh, said: “Creating the complexities of real-world sea states at laboratory scale is central to the mission of FloWave. This work takes this to a new level by using the multi-directional capabilities of the wave basin to isolate these important wave breaking behaviours.”

Dr Ross Calvert from the University of Edinburgh added: “This is the first time we've been able to measure wave heights at such high spatial resolution over such a big area, giving us a much more detailed understanding of complex wave breaking behaviour."

The study was conducted by a research consortium including experts from The University of Manchester, University of Oxford, University of Edinburgh, University College Dublin, ENS Paris-Saclay and TU Delft.

The University of Manchester is proud to share that Dr Bovinille Anye Cho has been announced as a recipient of the prestigious (CDF), a programme aimed at developing underrepresentation in UK STEM academia.

Dr Anye Cho is one of eight outstanding researchers selected in the first cohort of CDFs, who are undertaking groundbreaking research that can benefit society and further human understanding.

His research centres on revolutionising bioenergy processes to become more environmentally sustainable, in particular, anaerobic digestion (AD), which is a process that transforms agricultural and food waste into a clean energy source known as biomethane.

Although an effective way to manage waste, this process also creates a significant amount of carbon dioxide (CO₂) and impurities, which contributes to global warming.

Dr Anye Cho is exploring the use of microalgae, which can be used to convert CO₂ into valuable food supplements and healthcare products through photosynthesis. In the UK, where tons of agricultural and food waste are generated, incorporating algae technology into the exiting AD facilities could increase the production of clean energy, while yielding high-value bio renewables that are currently heavily dependent on imports.

Dr Anye Cho’s project aims to employ advanced mathematical modelling and Artificial Intelligence methods to ensure that facilities of various sizes can operate effectively for long durations, enabling stability and boosting the production of clean energy and valuable products. His fellowship will be based in the Department of Chemical Engineering, where he has served as a Research Associate since March 2023. He earned his PhD from the same department in January 2023, completing it in an impressive three years while publishing over 11 original scientific papers.

The Career Development Fellowships are currently running as a pilot programme with researchers from Black and Mixed Black heritage. The CDFs offer four years of funding (up to £690,000), mentoring and support to kickstart the careers of researchers from underrepresented groups.

The scheme was launched in response to 11 years of higher education data which showed Black heritage researchers leave academia at higher rates than those from other groups. The impact of this higher attrition rate is pronounced at senior levels of academic careers.

Sir Adrian Smith, President of the Royal Society, said: “We need an academic system where talented researchers can build a career, whatever their background. But we know that is not the case in the UK today – particularly for researchers of Black heritage.

“The variety and quality of research being undertaken by this first cohort of Royal Society Career Development Fellows suggests a bright future ahead if we can ensure more outstanding researchers develop their talents and follow their research passions.

“I hope this pilot and the support it offers can be a launchpad to achieve that.”

In addition to their fellowship funding and support from the Royal Society, the award holders will have access to networking and mentoring opportunities supported by the (BBSTEM) network.

If the pilot is shown to be effective, the CDF programme could be expanded to include researchers from other groups, where the data shows there is persistent underrepresentation.

Dr Mark Richards, Senior Teaching Fellow at Imperial College London and a member of the Royal Society’s Equality, Diversity and Inclusion Subcommittee who participated in the shortlisting and assessment panels for the CDFs, said:

“There are many reasons scientists from marginalised groups may leave academia, often it’s because they’re looking ahead and not seeing themselves reflected in those spaces.

“This scheme, which offers funding, mentoring and recognition from a body like the Royal Society can be the endorsement to propel these eight excellent academics to go on and grow their own research groups.

Overtime I hope it can become self-sustaining, creating a network of scientists in universities, and beyond, who can help raise aspirations and open doors.”

• Applications for the second year of Career Development Fellowships are due to open on 24 September 2024.
• Find out more about the Royal Society Career Development Fellowships .
• Read the Royal Society’s CDFs press release .

These findings have the potential to accelerate the discovery of novel, more efficient cryoprotectants - and may also allow for the repurposing of molecules already known to slow or stop ice growth.

Professor Matthew Gibson, from 91ֱ�� Institute of Biotechnology at The University of Manchester, added: “My team has spent more than a decade studying how ice-binding proteins, found in polar fish, can interact with ice crystals, and we’ve been developing new molecules and materials that mimic their activity. This has been a slow process, but collaborating with Professor Sosso has revolutionized our approach. The results of the computer model were astonishing, identifying active molecules I never would have chosen, even with my years of expertise. This truly demonstrates the power of machine learning.”

The full paper can be read .

Sugars play a crucial role in human health and disease, far beyond being just an energy source. Complex sugars called glycans coat all our cells and are essential for healthy function. However, these sugars are often hijacked by pathogens such as influenza, Covid-19, and cholera to infect us.

One big problem in treating and diagnosing diseases and infections is that the same glycan can bind to many different proteins, making it hard to understand exactly what’s happening in the body and has made it difficult to develop precise medical tests and treatments.

In a breakthrough, published in the journal , a collaboration of academic and industry experts in Europe, including from The University of Manchester and the University of Leeds, have found a way to create unnatural sugars that could block the pathogens.

The finding offers a promising avenue to new drugs and could also open doors in diagnostics by ‘capturing’ the pathogens or their toxins.

, a researcher from at The University of Manchester, said “During the Covid-19 pandemic, our team introduced the first lateral flow tests which used sugars instead of antibodies as the ‘recognition unit’. But the limit is always how specific and selective these are due to the promiscuity of natural sugars. We can now integrate these fluoro-sugars into our biosensing platforms with the aim of having cheap, rapid, and thermally stable diagnostics suitable for low resource environments.”

Professor Bruce Turnbull, a lead author of the paper from the School of Chemistry and Astbury Centre for Structural Molecular Biology at The University of Leeds, said “Glycans that are really important for our immune systems, and other biological processes that keep us healthy, are also exploited by viruses and toxins to get into our cells. Our work is allowing us to understand how proteins from humans and pathogens have different ways of interacting with the same glycan. This will help us make diagnostics and drugs that can distinguish between human and pathogen proteins.”

The researchers used a combination of enzymes and chemical synthesis to edit the structure of 150 sugars by adding fluorine atoms. Fluorine is very small meaning that the sugars keep their same 3D shape, but the fluorines interfere with how proteins bind them.

, a researcher from 91ֱ�� Institute of Biotechnology at The University of Manchester, said “One of the key technologies used in this work is biocatalysis, which uses enzymes to produce the very complex and diverse sugars needed for the library. Biocatalysis dramatically speeds up the synthetic effort required and is a much more green and sustainable method for producing the fluorinated probes that are required.”

They found that some of the sugars they prepared could be used to detect the cholera toxin – a harmful protein produced by bacteria – meaning they could be used in simple, low-cost tests, similar to lateral flow tests, widely used for pregnancy testing and during the COVID-19 pandemic.

Dr Kristian Hollie, who led production of the fluoro-sugar library at the University of Leeds, said: “We used enzymes to rapidly assemble fluoro-sugar building blocks to make 150 different versions of a biologically important glycan. We were surprised to find how well natural enzymes work with these chemically modified sugars, which makes it a really effective strategy for discovering molecules that can bind selectively.”

The study provides evidence that the artificial “fluoro-sugars” can be used to fine-tune pathogen or biomarker recognition or even to discover new drugs. They also offer an alternative to antibodies in low-cost diagnostics, which do not require animal tests to discover and are heat stable.

The research team included researchers from eight different universities, including 91ֱ��, Imperial College London, Leeds, Warwick, Southampton, York, Bristol, and Ghent University in Belgium.

The £5.5 million project, funded by Horizon Europe and the Swiss State Secretariat for Education, Research and Innovation (SERI), will involve a four-year collaboration between 91ֱ�� and academic and industry experts from ETH Zurich, the University of Vienna, Universitat Politècnica de Catalunya, NKT Cable Group, Shell Research Ltd, S&B Insurance Advisors, and Arttic Innovation. This initiative aims to develop the enabling technology that supports a sustainable European electricity grid. 

Named DCDYNAMIC (Accelerating DC Dynamic Export Cable Technology for a Sustainable European Electricity Grid), the project will consist of three distinct parts. Firstly, understanding how electrical, mechanical, and thermal stresses impact these cables; secondly how to create real-world conditions for reliable testing; and thirdly, construction of a 320 kV high-voltage DC cable prototype, tested at scale using the simulated conditions created through the project. 

DCDYNAMIC will be led by , Reader in High Voltage Engineering in the Department of Electrical and Electronic Engineering, which houses the UK’s largest academic electrical test and research facility, the . He will be joined by , Professor of Materials Science and Chief Scientist at the , the UK’s national institute for material innovation; and , Reader in Nanomaterials based at the  

DCDYNAMIC is one of the earliest Horizon Europe projects since the UK re-joined, with a UK university serving as the lead coordinator. 

Project lead, Dr Tony Chen, said: “Being granted European Commission funding as the project coordinator on this scale demonstrates the competitiveness of UK institutions.”  

Home to over 2000 wind farms, and with the largest offshore wind capacity in the world, wind power already plays a leading part in the UK’s energy landscape. This offshore resource provides a range of advantages over its onshore equivalent; farms can be built at a greater scale (the UK currently has the biggest offshore wind farm in the world, Hornsea 1 near the Yorkshire coast), winds are higher and more consistent, and any visual impact concerns are significantly reduced.   

A leading nanomedicine researcher at The University of Manchester has secured a €1.5m (£1.3m) European Research Council (ERC) Starting Grant to push forward pioneering research on Alzheimer’s disease and glioblastoma.

The five-year project, NanoNeuroOmics, aims to combine breakthroughs in nanotechnology, protein analysis, and blood biomarker discovery to make advances in two key areas.

First, the team led by will explore the use of nanoparticles to enrich and isolate brain-disease specific protein biomarkers in blood. These discoveries could pave the way for simple, reliable blood tests that diagnose Alzheimer’s and glioblastoma in their early stages.

Second, the research will investigate the phenomenon of “inverse comorbidity,” which suggests that having one of these conditions may reduce the risk of developing the other. Dr. Hadjidemetriou and her team will explore this surprising relationship to uncover any deeper biological connection that could lead to new treatment pathways.

Building on her 2021 research, where Dr. Hadjidemetriou developed a nanoparticle-enabled technology to detect early signs of neurodegeneration in blood, this project has the potential to transform how these brain diseases are diagnosed and treated.

Dr. Hadjidemetriou’s previous work involved using nano-sized particles, known as liposomes, to "fish" disease-specific proteins from the blood. This breakthrough enabled her team to discover proteins directly linked to neurodegeneration processes in the brain, among thousands of other blood-circulating molecules. In animal models of Alzheimer’s, this nano-tool successfully captured hundreds of neurodegeneration-associated proteins. Once retrieved from the bloodstream, the molecular signatures on the surface of these proteins were analysed, offering a clearer picture of the disease at a molecular level.

Now, Dr. Hadjidemetriou's team will evolve this expertise to identify highly specific biomarkers by tracking protein changes in both blood and brain over time and across different stages of Alzheimer's and glioblastoma. By working with different nanomaterials, they hope to isolate these key protein markers from the complex mix of molecules in the blood.

The  NanoNeuroOmics project’s multidisciplinary approach brings together experts in nanotechnology and omics sciences to develop methods for detecting and potentially treating these diseases with greater precision. Research will be conducted at The University of Manchester’s , a cutting-edge facility dedicated to advancing nanoscale technologies. The Centre's focus spans multiple fields, including omics, neurology, therapeutics, and materials science.

Dr. Hadjidemetriou’s team is also part of Manchester’s vibrant 2D materials science community, home to the discovery of graphene 20 years ago, continuing the university’s legacy of scientific innovation.

Lithium-ion batteries, which power everything from smartphones and laptops to electric vehicles, store energy through a process known as ion intercalation. This involves lithium ions slipping between layers of graphite - a material traditionally used in battery anodes, when a battery is charged. The more lithium ions that can be inserted and later extracted, the more energy the battery can store and release. While this process is well-known, the microscopic details have remained unclear. The 91ֱ�� team’s discovery sheds new light on these details by focusing on bilayer graphene, the smallest possible battery anode material, consisting of just two atomic layers of carbon.

In their experiments, the researchers replaced the typical graphite anode with bilayer graphene and observed the behaviour of lithium ions during the intercalation process. Surprisingly, they found that lithium ions do not intercalate between the two layers all at once or in a random fashion. Instead, the process unfolds in four distinct stages, with lithium ions arranging themselves in an orderly manner at each stage. Each stage involves the formation of increasingly dense hexagonal lattices of lithium ions.

, who led the research team, commented, "the discovery of 'in-plane staging' was completely unexpected. It revealed a much greater level of cooperation between the lattice of lithium ions and the crystal lattice of graphene than previously thought. This understanding of the intercalation process at the atomic level opens up new avenues for optimising lithium-ion batteries and possibly exploring new materials for enhanced energy storage."

The study also revealed that bilayer graphene, while offering new insights, has a lower lithium storage capacity compared to traditional graphite. This is due to a less effective screening of interactions between positively charged lithium ions, leading to stronger repulsion and causing the ions to remain further apart. While this suggests that bilayer graphene may not offer higher storage capacity than bulk graphite, the discovery of its unique intercalation process is a key step forward. It also hints at the potential use of atomically thin metals to enhance the screening effect and possibly improve storage capacity in the future.

This pioneering research not only deepens our understanding of lithium-ion intercalation but also lays the groundwork for the development of more efficient and sustainable energy storage solutions. As the demand for better batteries continues to grow, the findings in this research could play a key role in shaping the next generation of energy storage technologies.

The (NGI) is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field – a community of research specialists delivering transformative discovery. This expertise is matched by £13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

The substantial investment from the , marks the fourth phase of The’s (SSI) mission to transform research culture by establishing the principle that reliable, reproducible, and reusable software is necessary across all research disciplines.

The SSI, which is based at the universities of Manchester, Edinburgh, and Southampton, was established in 2010 as the world’s first organisation dedicated to improving software in research, with The University of Manchester playing a central role in its success.

The next phase will focus on tackling critical challenges in research software, including environmental sustainability, equality, diversity, inclusion, and accessibility, as well as the rising interest in Artificial Intelligence (AI) and Machine Learning.

The next phase of the programme will run from 2024 to 2028 and will be led by the .

It is fourth time the SSI has been entrusted with public funding to carry out its mission of transforming research culture by establishing the principle that reliable, reproducible, and reusable software is necessary across all research disciplines.

It achieves this by working with, and investing in, individuals and organisations from across the sector. The SSI’s “collaborate, not compete” ethos has allowed research software to move towards becoming a first-class citizen in the research landscape.

Christopher Smith, Executive Chair  of the Arts and Humanities Research Council, said: “Software plays a fundamental role in all disciplines of research. That’s why it’s so important that we invest in supporting the development of research software that is top quality, meets the needs of our research communities, is environmentally sustainable and is ready for the future. 

“This record £10.2 million investment is part of the UKRI Digital Research Infrastructure programme’s ongoing investment in evolving existing capability and supporting new infrastructure. It reflects the SSI’s strong track record and the importance of its work for the future of research. I am delighted that AHRC will be hosting this investment for all UKRI communities for the next four years.”

Neil Chue Hong, SSI Director and Professor of Research Software Policy and Practice, added: “Every modern societal advance is driven by research which relies on software. From weather forecasting to whether we can build new narratives for the next decade, it’s important that we provide equitable access to the digital tools and skills enabling this. This grant - which will see the SSI into its 18th year - enables us to work with the research community to build capability and expertise, ensuring a sustainable future for research software.”

The SSI was founded in 2010 thanks to funding from the (EPSRC). In 2016, the (ESRC) and the (BBSRC) joined EPSRC to further invest and help continue the work of the SSI throughout its second phase. The third phase was funded by all UKRI research councils.

With most volcanic activity taking place underground unobserved, for the first time scientists have been able to capture vesiculation kinetics in basaltic magmas in real time. Published today in , the study sheds new light on one of nature’s most astonishing phenomena.

Volcanic eruptions differ drastically, ranging from gentle effusive lava flows to highly explosive events - or sometimes switching between the two at a moment’s notice.

At the worst end of the scale, volcanic eruptions eject massive volumes of magma and volcanic gases into the air. This causes catastrophic local damage and often prompts wide-reaching global effects too, like air traffic space closure and changes in weather patterns.

Scientists highlighted that eruptive style is influenced by how gas dissolved in magma is released. Contrasts can be drawn between how a waiter opens a bottle of champagne in a restaurant, and how champagne pops when shaken by Grand Prix winners. Despite both bottles having the same amount of gas, the champagne leaves the bottles at vastly different speeds.

Volcanic eruption styles depend on how easily magma decouples from gas during ascent, with stronger gas-melt coupling leading to more explosive reactions. This study allowed scientists to observe and quantify real-time bubble growth and coalescence in magma as it reaches the surface.

The pressure vessel used in the laboratory experiments was thick enough to contain vast amounts of stored energy, and X-rays (the I12-JEEP synchrotron beamline from Diamond Light Source) were used to see through the magma sample and make the observations.

, Research Associate in the Department of Earth and Environmental Sciences at The University of Manchester and lead author of the study, commented: “The experimental results obtained in this study through the combination of our novel vessel apparatus and X-ray synchrotron radiography, offer an improved understanding of coupling and decoupling between magma and volatiles during ascent in the conduit. This study provides insights into processes leading to eruptive style transitions and, ultimately, has fundamental implications for hazard assessment and risk mitigation in area of active basaltic volcanism.”

Pressure in the chambers could be increased or decreased in a controlled way, allowing scientists to see how expanding bubble walls are broken during coalescence at different pressures and temperatures, from 10km in the magmatic plumbing system right up to the conduit beneath a volcano.

The study is a result of a NERC-NFS large grant awarded to The University of Manchester, in addition to the universities of Bristol, Durham, Cambridge and Arizona State in the USA. A UKRI FLF project grant was also awarded to 91ֱ��, and the study was completed in collaboration with colleagues at ESRF in Grenoble, France who developed the novel experimental pressure vessel with windows used in the study.

The growth rates sourced from this new technique confirm previous estimations that used numerical and theoretical modelling. This study contributes to a better understanding of magma behaviour and will greatly improve knowledge of volcanic processes, in addition to helping with future hazard assessment and risk mitigation in areas of active volcanic activity.

The study, published in by scientists at The University of Manchester and led by the National Oceanography Centre (NOC), has found that currents sped up, slowed down, changed direction, and sometimes reversed direction completely, depending on the varying and uneven surfaces and features found on the ocean floor.

Previous models suggested that these currents would be continuous and steady. These findings will help scientists to understand the deep-sea pathways of nutrients that sustain deep-sea ecosystems, as well as assessing where microplastics and other pollutants accumulate in the ocean.

By better understanding how deep-sea currents interact with the seafloor, scientists can now more accurately interpret the deposits they leave behind. Those deposits act as long-term recorders of past climate change and can provide important clues about the potential impacts of future ocean changes. 

The seafloor is the final destination for particles such as sand, mud, organic carbon that provides food for seafloor organisms, and even pollutants. Accumulations of these particles in the deep sea are used to reconstruct past climates, natural hazards and ocean conditions. This provides valuable archives of climate change that extends far beyond historical records.

The lead scientist on the project, Dr Mike Clare of NOC, said: “It is important to understand the behaviour and pathways of currents that operate in the deep sea, to determine pathways of natural and human-made particles. This information helps identify where pollution is coming from, which ecosystems it will interact with, and how to make sense of the records preserved in deposits.

“However, there have been very few direct measurements made of currents that flow across the seafloor in deep waters. Most are made high above the seafloor, over short timescales, and only at individual locations. Until now we have not understood how dynamic seafloor currents can be in the deep sea.”

The new study, which involved researchers from the UK, Canada, Germany and Italy, analysed data from an extensive array of sensors to determine the variability in seafloor currents over four years. Thirty-four deep sea moorings were deployed in up to 2.5 km water depths, equipped with high-frequency Acoustic Doppler Current Profilers - likened to an underwater speed camera that measures seafloor currents.

The study’s lead author, Dr Lewis Bailey, formerly of NOC and now at University of Calgary, said “The ocean bottom currents offshore Mozambique are far more variable than we expected. Just like currents in the upper ocean, their intensity changes between seasons and can even flip backwards and forwards over the course of several hours.”

from The University of Manchester, and a co-author of the study, added: “Seeing how these currents behave is a bit like observing the weather in 91ֱ�� - always changing and often surprising. But observing change in the deep sea is really challenging and, until now, we have had a poor understanding of what background conditions are like in the deep-sea.”

Professor Elda Miramontes from the University of Bremen, also a co-author of the study, said: “These are the first measurements of deep-sea currents across such a large area, long duration and so close to the seafloor. This makes them extremely valuable as they will help improve our models for reconstructing past changes related to climate change in the ocean.”

Dr Mike Clare of NOC, added: “The deep sea can be extremely dynamic and this study underlines the importance of sustained observations, which provide critical information on understanding the ocean. More detailed observations are critical for understanding the important role bottom currents play in transporting sediment, carbon and pollutants across our planet.”

The full study “Highly variable deep-sea currents over tidal and seasonal timescales” was published in Nature Geoscience: .

Antibiotics are given to kill bad bacteria, however with just one mutation a bacteria can evolve to become resistant to that antibiotic, making common infections potentially fatal.

The new research, published today in the journal , used high-performance computing to simulate more than 8,000 years of bacterial evolution, allowing scientists to predict mechanisms that control mutation rates. They then made more than 15,000 cultures of E. coli in lab conditions to test their predictions - that’s so many that if you lined up all of the bacteria in this study, they would stretch 860,000km, or wrap around the Earth more than 20 times!

The tests revealed that bacteria living in a lowly populated community are more prone to developing antibiotic resistance due to a naturally occurring DNA-damaging chemical, peroxide. In crowded environments, where cells are more densely packed, bacteria work collectively to detoxify peroxide, reducing the likelihood of mutations that lead to antibiotic resistance.

The finding could help develop "anti-evolution drugs" to preserve antibiotic effectiveness by limiting the mutation rates in bacteria.

Lead researcher from The University of Manchester, said: "Antibiotic resistance presents an existential challenge to human health. Bacteria rapidly evolve resistance to the antibiotic drugs we use to treat infections, while new drugs aren’t being developed fast enough to keep up.

“If we can’t keep antibiotics working, routine surgery could be a life-or-death encounter, with common infections becoming untreatable.

“By understanding the environmental conditions that influence mutation rates, we can develop strategies to safeguard antibiotic effectiveness. Our study shows that bacterial mutation rates are not fixed and can be manipulated by altering their surroundings, which is vital on our journey to combat antibiotic resistance."

Peroxide, a chemical found in many environments, is key to this process. When E. coli populations become denser, they work together to lower peroxide levels, protecting their DNA from damage and reducing mutation rates. The study showed that genetically modified E. coli that is unable to break down peroxide had the same mutation rates, no matter the population size. However, when helper cells that could break down peroxide were added, the mutation rate in these genetically modified E. coli decreased.

The research builds on previous findings by group, which indicated that denser bacterial populations experience lower mutation rates. The current study uncovers the specific mechanism behind this phenomenon, highlighting the role of collective detoxification in controlling mutation rates.

The research team, part of the Microbial Evolution Research in 91ֱ�� (MERMan) collective, conducted this extensive study with contributions from researchers at all career stages. The lab work was primarily carried out by a PhD student, alongside six undergraduate and master's students, under the guidance of four lab group leaders.

In total 68  of the most promising research leaders will be funded £104 million to lead research into global issues and to commercialise their innovations in the UK.

UKRI’s flagship Future Leaders Fellowships allow universities and businesses to develop their most talented early career researchers and innovators and to attract new people to their organisations, including from overseas.

Dr Fiona Whelan is a Senior Lecturer in Computational Biology and Bioinformatics at The University of Manchester whose research focusses on combining classical microbiology techniques with cutting-edge bioinformatic methodologies.

Fiona was previously a University of Nottingham Anne McLaren Fellow (2020-3) and Marie Skłodowska-Curie Independent Fellow (2018-20). She moved to the UK from McMaster University, Canada where she conducted her PhD research on the human microbiome.

She said: “I am so excited to join this cohort of UKRI Future Leaders Fellows. My research programme – focussed on understanding how bacterial interactions within mixed microbial communities contribute to pathogenicity and disease progression in cystic fibrosis – is interdisciplinary in nature.

“This Fellowship gives me the unique opportunity to assemble a world-leading, interdisciplinary team who will have the experience and expertise to answer these important questions and – ultimately – hopefully improve the lives of individuals with cystic fibrosis.”

Dr Laura Richards, a Dame Kathleen Ollerenshaw Fellow based at the Department of Earth and Environmental Sciences, University of Manchester, has been awarded a UKRI Future Leaders Fellowship to launch a project called AQUAROAD.

AQUAROAD aims to create a roadmap towards improved groundwater quality management in the context of the Global South by bringing together interdisciplinary approaches to understand (bio)geochemical controls and to support evidence-based decision making for effective remediation strategies for water supplies used for drinking.

The approach, aligned with the UN Sustainable Development Goals, will be developed and demonstrated in contrasting areas in India and East Africa, with flexibility for future adaptation.

Dr Richards said: “I’m thrilled and deeply grateful to have been awarded a Future Leaders Fellowship. This fellowship is an exciting springboard for ambitious research with an excellent network of collaborators and potential for positive impact on society.”

UKRI Chief Executive, Professor Dame Ottoline Leyser, said: “UKRI’s Future Leaders Fellowships provide researchers and innovators with long-term support and training to develop ambitious, transformative ideas.

“The programme supports the research and innovation leaders of the future to transcend disciplinary and sector boundaries, bridging the gap between academia and business.  

The fellows announced today demonstrate how these awards continue to drive excellence, and to shorten the distance from discovery to prosperity and public good.”

The breakthrough, published in the journal , could significantly improve accessibility of essential protein-based drugs in developing countries where cold storage infrastructure may be lacking, helping efforts to diagnose and treat more people with serious health conditions.

The researchers, from the Universities of Manchester, Glasgow and Warwick, have designed a hydrogel – a material mostly made of water – that stabilises proteins, protecting its properties and functionality at temperatures as high as 50°C.

The technology keeps proteins so stable that they can even be sent through the post with no loss of effectiveness, opening up new possibilities for more affordable, less energy-intensive methods of keeping patients and clinics supplied with vital treatments.

Protein therapeutics are used to treat a range of conditions, from cancer to diabetes and most recently to treat obesity and play a vital role in modern medicine and biotechnology. However, keeping them stable and safe for storage and transportation is a challenge. They must be kept cold to prevent any deterioration, using significant amounts of energy and limiting equitable distribution in developing countries.

The medicines also often include additives – called excipients – which must be safe for the drug and its recipients limiting material options.

The findings could have major implications for the diagnostics and pharmaceutical industries.

, is one of the paper’s corresponding authors. He said: “In the early days of the Covid vaccine rollout, there was a lot of attention given in the news media to the challenges of transporting and storing the vaccines, and how medical staff had to race to put them in people’s arms quickly after thawing.  

“The technology we’ve developed marks a significant advance in overcoming the challenges of the existing ‘cold chain’ which delivers therapeutic proteins to patients. The results of our tests have very encouraging results, going far beyond current hydrogel storage techniques’ abilities to withstand heat and vibration. That could help create much more robust delivery systems in the future, which require much less careful handling and temperature management.”

The hydrogel is built from a material called a low molecular weight gelator (LMWG), which forms a three-dimensional network of long, stiff fibres. When proteins are added to the hydrogel, they become trapped in the spaces between the fibres, where they are unable to mix and aggregate – the process which limits or prevents their effectiveness as medicines.

The unique mechanical properties of the gel’s network of fibres, which are stiff but also brittle, ensures the easy release of a pure protein. When the protein-storing gel is stored in an ordinary syringe fitted with a special filter, pushing down on the plunger provides enough pressure to break the network of fibres, releasing the protein. The protein then passes cleanly through the filter and out the tip of the syringe alongside a buffer material, leaving the gel behind.

In the paper, the researchers show how the hydrogel works to store two valuable proteins: insulin, used to treat diabetes, and beta-galactosidase, an enzyme with numerous applications in biotechnology and life sciences.

Ordinarily, insulin must be kept cold and still, as heating or shaking can prevent it from being an effective treatment. The team tested the effectiveness of their hydrogel suspension for insulin by warming samples to 25°C and rotating them at 600 revolutions per minute, a strain test far beyond any real-world scenario. Once the tests were complete, the team were able to recover the entire volume of insulin from the hydrogel, showing that it had been protected from its rough treatment.

The team then tested samples of beta-galactosidase in the hydrogel, which was stored at a temperature of 50°C for seven days, a level of heat exceeding any realistic temperature for real-world transport. Once the enzyme was extracted from the hydrogel, the team found it retained 97% of its function compared against a fresh sample stored at normal temperature.

A third test saw the team put samples of proteins suspended in hydrogel into the post, where they spent two days in transit between locations. Once the sample arrived at its destination, the team’s analysis showed that the gels’ structures remained intact and the proteins had been entirely prevented from aggregating.

is the paper’s other corresponding author. He said: “Delivering and storing proteins intact is crucial for many areas of biotechnology, diagnostics and therapies. Recently, it has emerged that hydrogels can be used to prevent protein aggregation, which allows them to be kept at room temperature, or warmer. However, separating the hydrogel components from the protein or proving that they are safe to consume is not always easy. Our breakthrough eliminates this barrier and allows us to store and distribute proteins at room temperature, free from any additives, which is a really exciting prospect.”

The team are now exploring commercial opportunities for this patent-pending technology as well as further demonstrating its applicability. 

Researchers from the University of East Anglia and Diamond Light Source Ltd also contributed to the research. The team’s paper, titled ‘Mechanical release of homogenous proteins from supramolecular gels’, is published in Nature.

The research was supported by funding from the European Union’s Horizon 2020 programme, the European Research Council, the Royal Society, the Engineering and Physical Sciences Research Council (EPSRC), the University of Glasgow and UK Research and Innovation (UKRI).

Today, UK Research and Innovation (UKRI), has announced £34 million investment in a ground-breaking project, BioFAIR, which aims to overhaul research data management across the nation.

The project, initially proposed by the ELIXIR-UK community, which is co-led by Professor Carole Goble from the University of Manchester, aims to establish a cohesive, UK-wide digital research infrastructure that bridges current gaps between researchers, digital research technical professionals, existing institutional digital research infrastructures, and the funder-community partnership.

It will deliver a step change in the UK’s capability to translate existing and future life science data assets into world leading research in response to some of society’s most pressing challenges.

ELIXIR-UK is the UK Node of ELIXIR, a European project to integrate life sciences data across the continent with the aim of facilitating the linking of data worldwide. Professor Goble has been co-leading on the business case and investment activity for the project in partnership with the Earlham Institute and UKRI over the last six years and has played an instrumental role in securing the award for the UK. She is also leading the architecture requirements development of the BioFAIR Commons.

BioFAIR will be a catalyst for innovation and discovery and over its five-year life span will:

• accelerate the adoption of findable, accessible, interoperable and reusable (FAIR) data principles across the UK life sciences, making it more useful and valuable to researchers than ever before
• unify the UK’s currently fragmented digital research landscape, fostering unprecedented opportunities for collaboration and coordination among the national life sciences community
• break down barriers to democratise data accessibility, giving UK researchers the resources and autonomy needed for innovation and discovery to flourish
• coordinate and deliver extensive training and support for practitioners at all levels, building critical workforce capacity and securing the UK’s position as a global leader in life sciences

Fundamental to the BioFAIR concept are its four key capabilities. Each will be assembled from existing data tools and services developed and deployed by the UK and international life science research communities.

Collectively, the four capabilities signify an important ethos of one community driving and sharing responsibility for the management and use of national assets to maximise accessibility, usability and impact.

The data commons will catalogue sources of existing datasets, making them easily accessible to life science researchers. It will support FAIR data management throughout the data lifecycle, from the point of collection to deposition and, crucially, to reuse.

The method commons will enable the collaborative use of shared computational workflows with a national workflow capability. It will feature a national repository of trusted and curated data methods and workflows, contributed by the life sciences research community, supporting reproducible data analytics and advancing

The community centre will provide a focal point for sharing expertise, best practice and troubleshooting within disciplines.

The knowledge centre will enable those driving the collection and curation of existing knowledge resources and training materials to advance best practice in research data management.

Together, the community and knowledge centres will create a collaborative environment that supports more effective dissemination of research data management knowledge and skills across the life sciences research community.

Mission critical 

Put simply, BioFAIR is mission critical to the future of UK life sciences research. At its core the project will deliver major efficiency gains by streamlining research data management.

By better connecting research teams and championing the reuse of data and methods, BioFAIR will help accelerate research, leading to faster scientific breakthroughs as a result.

But BioFAIR adds significantly more value than efficiency alone. It will:

• pioneer innovation, with its state-of-the-art tools and methods paving the way for future scientific success
• future-proof the UK life sciences ecosystem by integrating advanced computational tools and methods to set the stage for new innovations that can be translated and commercialised for maximum impact
• support economic growth and prosperity by upskilling the life sciences research data management workforce and enabling new opportunities for the UK’s scientific leadership

Community driven from the outset, the concept of BioFAIR originated as an idea submitted to BBSRC’s by the ELIXIR-UK team.

This collaborative ethos remains at the heart of BioFAIR, complemented by additional UK and international initiatives to ensure best practices are shared and interoperability across disciplines is promoted.

BioFAIR’s success heavily relies upon the combined ability and proven track record of the UK life science research community in developing and operating research data management tools and services. 

As the awarded hosts of BioFAIR’s coordinating hub, the Earlham Institute’s strengths will be complemented by a skilled and distributed network of UK partners responsible for project leadership and delivery.

Dr Sarah Perkins, Executive Director for Strategic Planning, Evidence and Engagement at BBSRC and the UKRI Senior Responsible Officer for BioFAIR, said: “Digital research infrastructure has fast become as critical to UK bioscience as physical infrastructure. 

“The BioFAIR project will provide the backbone for ground-breaking research, enabling researchers to tackle key societal challenges head-on. By democratising access to crucial data and methods, BioFAIR ensures that the UK life science community can innovate faster and more effectively than ever before.”

Gerry Reilly, Interim Director of BioFAIR, said: “Our vision is to create a powerful federated digital research infrastructure that revolutionises UK life science research. By leveraging established best practices and capabilities, we will build a national platform that ensures the effective adoption of FAIR principles and drives efficiency across all UK life science research institutions. 

“Developed by the research community for the research community, BioFAIR will transform the future face of the UK life sciences.”

or email your questions to info@biofair.uk.

Peptides are comprised of small chains of amino acids, which are also the building blocks of proteins. Peptides play a crucial role in our bodies and are used in many medicines to fight diseases such as cancer, diabetes, and infections. They are also used as vaccines, nanomaterials and in many other applications. However, making peptides in the lab is currently a complicated process involving chemical synthesis, which produces a lot of harmful waste that is damaging to the environment.

In a new breakthrough, published in the journal , 91ֱ�� scientists have discovered a new family of ligase enzymes – a type of molecular glue that can help assemble short peptide sequences more simply and robustly, yielding significantly higher quantities of peptides compared to conventional methods.

The breakthrough could revolutionise the production of treatments for cancer and other serious illnesses, offering a more effective and environmentally friendly method of production.

For many years, scientists have been working on new ways to produce peptides. Most existing techniques rely on complex and heavily protected amino acid precursors, toxic chemical reagents, and harmful volatile organic solvents, generating large amounts of hazardous waste. The current methods also incur high costs, and are difficult to scale up, resulting in limited and expensive supplies of important peptide medicines.

The team in 91ֱ�� searched for new ligase enzymes involved in the biological processes that assemble natural peptides in simple bacteria. They successfully isolated and characterised these ligases and tested them in reactions with a wide range of amino acid precursors. By analysing the sequences of the bacterial ligase enzymes, the team identified many other clusters of ligases likely involved in other peptide pathways.

The study provides a blueprint for how peptides, including important medicines, can be made in the future.

, who also worked on the project said, “The ligases we discovered provide a very clean and efficient way to produce peptides. By searching through available genome sequence data, we have found many types of related ligase enzymes. We are confident that using these ligases we will be able to assemble longer peptides for a range of other therapeutic applications.”

Following the discovery, the team will now optimise the new ligase enzymes, to improve their output for larger scale peptide synthesis. They have also established collaborations with a number of the top pharmaceutical companies to help with rolling out the new ligase enzyme technologies for manufacturing future peptide therapeutics.

This prestigious award is designed to support students, postdoctoral researchers, recent graduates, and encourage new student cohorts to engage with MEC, in launching new businesses that involve graphene or other 2D materials. It’s all about sparking innovation and making a real impact in the commercial world, turning groundbreaking research into real, game-changing solutions for the future.

With awards of £50,000 and £20,000, we’re excited to celebrate the individuals or teams who showed how their graphene-related technology can be turned into a business. The applications were judged based on how solid their plans were for creating a new business related to graphene or 2D materials.

This award gives winners the perfect launchpad they need to kickstart their business. The University of Manchester understands how crucial flexible early-stage financial support is for these kinds of ventures, to help make these dreams a reality and bring a product or technology to the market.

This year, the top prize of £50,000 went to Kun Huang of Solar Ethos. Kun has a Master’s degree in Corrosion Control Engineering and a PhD in Material Physics. The second prize of £20,000 was awarded to Hafiza Hifza Nawaz of Fabstics, who has a PhD in Materials. We also congratulate the other finalists - Mohammadhossein Saberian of EcoTarTech and Ozan Zehni of Dorlion SHM.

The winners, pictured above with Deputy Vice-Chancellor & Deputy President Luke Georghiou:

• Left: First place - Solar Ethos
• Right: Second place - Fabstics

All finalists received support throughout the competition, which included: pitching workshops, help with applications by Scott Dean (CEO of Graphene Trace), and IP advice from Innovation Factory. These resources were key in helping them navigate the challenges of starting a business and turning their groundbreaking ideas into real-world solutions.

Our top-tier judges included Professor Luke Georghiou, Deputy President and Deputy Vice-Chancellor at the University of Manchester; Lynn Sheppard, Masood Entrepreneurship Centre Director; Jessica McCreadie, Investment Director at Northern Gritstone; James Baker, CEO Graphene @91ֱ�� at The University of Manchester; and Gareth Jones, Project Manager - Electronics at the University of Manchester Innovation Factory. Their expertise and dedication to encouraging innovation played a key role in choosing projects that could make a big difference.

We offer a huge congratulations to all the participants! We can’t wait to see the fantastic impact of their innovative work in the commercial world. By supporting these entrepreneurs, we're not only helping them achieve their dreams but also paving the way for future advancements that can tackle some of the world's most pressing challenges.

Along with the awards, we heard inspiring speeches from high-profile individuals such as Lynn Sheppard, Professor James Baker, Dr. Vivek Koncherry, Liam Johnson, and Professor Luke Georghiou. They shared amazing insights about graphene and other 2D materials, emphasising the transformative potential of these technologies and the importance of ongoing innovation. We were also joined via Zoom from California by Dr. Eli Harari, founder of SanDisk, the memory storage technology company. He encouraged attendees to "Think Big!".

Eli & Britt Harari Award 2021 winner Dr. Vivek Koncherry, the CEO of Graphene Innovations 91ֱ��, is making significant strides in connecting graphene technology with global business opportunities. Last year, he signed a $1 billion partnership with Quazar Investment Company to create a new company in the UAE aimed at tackling global sustainability challenges. Recognised as 91ֱ��'s answer to Elon Musk, Vivek recently impressed judges to win the North West heat of KPMG’s Tech Innovator in the UK 2024. With a strong background as an alumnus and researcher from The University of Manchester, Vivek exemplifies the spirit of entrepreneurship and innovation.

Some notable quotes about the competition include Lynn Sheppard's encouragement, "For all the winners and nominees, your journey does not stop here, it goes on," and Prof. James Baker's insight, "Graphene can make a big difference in addressing the climate change challenges." Dr. Vivek Koncherry highlighted 91ֱ��'s entrepreneurial spirit by stating, "91ֱ�� is very good for entrepreneurship," while Dr. Eli Harari inspired with, "We need people like you to aspire in making the world better." Liam Johnson appreciated the award's impact, saying, "The award allowed me to turn this idea to something tangible," and Prof. Luke Georghiou emphasised the importance of support with, "It's our duty to build an ecosystem to support the development of graphene."

Their words emphasised the event's theme of driving change and shaping a brighter future through cutting-edge research and entrepreneurship, wrapping up the event on an exhilarating high.

Thirty years after the Cosmic Microwave Background (CMB) spectrum was first precisely characterised by NASA's Cosmic Background Explorer (COBE) mission, a new experiment – known as BISOU (for Balloon Interferometer for Spectral Observations of the Universe) – is expected to significantly advance these measurements, gaining a factor of ~25 in sensitivity.

If successful, the results could provide unprecedented insights into the Universe's thermal history, validate predictions of the standard Big Bang Theory and potentially reveal new physics beyond our current understanding, marking a transformational step towards an ambitious future space-based CMB spectrometer to form part of the .

The CMB is leftover radiation from the time when the Universe began. Although the CMB is everywhere in the Universe, humans can't see it with the naked eye. But, using specialist equipment, it can be made visible even through the atmosphere’s curtain, offering novel insights into the Universe’s earliest moments.  

While the CMB’s near-perfect blackbody spectrum was first accurately measured three decades ago, and space missions such as WMAP and Planck have since revolutionised our understanding of the Universe by mapping the spatial variations in CMB temperature and linear polarisation across the sky, tiny deviations in the CMB known as spectral distortions remain largely unexplored. These distortions, predicted by theory, carry vital information about various cosmic processes in regimes that have not previously been explored.

With BISOU, scientists are intensively working on a new balloon-borne differential spectrometer to measure the distortions. The Phase 0 study, which concluded earlier this year, has already demonstrated the feasibility. Now, moving into Phase A, over the next two years, the consortium of researchers from France, Italy, Ireland, Spain, the UK, the USA and Japan, will finalise the detailed concept of the BISOU stratospheric balloon project before hopefully taking it to the skies in 2028/29.

The specialist equipment – a so-called Fourier Transform Spectrometer - builds on the long heritage of the COBE/FIRAS instrument and leverages insights from earlier studies like NASA's PIXIE and the European Space Agency's FOSSIL mission proposals.

The project is coordinated by Professor Bruno Maffei and the Institute of Space Astrophysics (IAS  - Institut d’Astrophysique Spatiale) Cosmology team and is funded by the French National Centre for Space Studies (CNES), which recently announced the transition of BISOU to Phase A.

Electrochemical processes are essential in renewable energy technologies like batteries, fuel cells, and electrolysers. However, their efficiency is often hindered by slow reactions and unwanted side effects. Traditional approaches have focused on new materials, yet significant challenges remain.

The 91ֱ�� team, led by , has taken a novel approach. They have successfully decoupled the inseparable link between charge and electric field within graphene electrodes, enabling unprecedented control over electrochemical processes in this material. The breakthrough challenges previous assumptions and opens new avenues for energy technologies.

Dr Marcelo Lozada-Hidalgo sees this discovery as transformative, “We’ve managed to open up a previously inaccessible parameter space. A way to visualise this is to imagine a field in the countryside with hills and valleys. Classically, for a given system and a given catalyst, an electrochemical process would run through a set path through this field. If the path goes through a high hill or a deep valley – bad luck. Our work shows that, at least for the processes we investigated here, we have access to the whole field. If there is a hill or valley we do not want to go to, we can avoid it.”

The study focuses on proton-related processes fundamental for hydrogen catalysts and electronic devices. Specifically, the team examined two proton processes in graphene:

Proton Transmission: This process is important for developing new hydrogen catalysts and fuel cell membranes.

Proton Adsorption (Hydrogenation): Important for electronic devices like transistors, this process switches graphene’s conductivity on and off.

Traditionally, these processes were coupled in graphene devices, making it challenging to control one without impacting the other. The researchers managed to decouple these processes, finding that electric field effects could significantly accelerate proton transmission while independently driving hydrogenation. This selective acceleration was unexpected and presents a new method to drive electrochemical processes.

Highlighting the broader implication in energy applications, Dr Jincheng Tong, first author of the paper, said “We demonstrate that electric field effects can disentangle and accelerate electrochemical processes in 2D crystals. This could be combined with state-of-the-art catalysts to efficiently drive complex processes like CO2 reduction, which remain enormous societal challenges.”

Dr Yangming Fu, co-first author, pointed to potential applications in computing: “Control of these process gives our graphene devices dual functionality as both memory and logic gate. This paves the way for new computing networks that operate with protons.  This could enable compact, low-energy analogue computing devices.”

Since publication, a review of the paper was included in Nature’s News & Views section, which summarises high-impact research and provides a forum where scientific news is shared with a wide audience spanning a range of disciplines: .

The National Graphene Institute (NGI) is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field – a community of research specialists delivering transformative discovery. This expertise is matched by £13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

Using a combination of mathematics, computer simulations, and laboratory experiments, the researchers have discovered how to design a robot with the optimum size, shape and the arrangement of its parts, allowing it to jump high enough to clear obstacles many times its own size.

The current highest-jumping robot can reach up to 33 metres, which is equivalent to 110 times its own size. Now, researchers have found out how to design a robot that could jump over 120 metres in the air – that’s more than the height of Big Ben’s tower.

The advancement, published in the journal , will revolutionise applications ranging from planetary exploration to disaster rescue to surveillance of hazardous or inaccessible spaces.

Co-author , Research Associate in Space Robotics at The University of Manchester, said: “Robots are traditionally designed to move by rolling on wheels or using legs to walk, but jumping provides an effective way of travelling around locations where the terrain is very uneven, or where there are a lot of obstacles, such as inside caves, through forests, over boulders, or even the surface of other planets in space.

“While jumping robots already exist, there are several big challenges in the design of these jumping machines, the main one being to jump high enough to overcome large and complicated obstacles. Our design would dramatically improve the energy efficiency and performance of spring-driven jumping robots.”

The researchers found that traditional jumping robots often take off before fully releasing their stored spring energy, resulting in inefficient jumps and limiting their maximum height. They also found that they wasted energy by moving side to side or rotating instead of moving straight up.

The new designs must focus on removing these undesirable movements while maintaining the necessary structural strength and stiffness.

Co-author, Senior Lecturer in Aerospace Engineering, said: “There were so many questions to answer and decisions to make about the shape of the robot, such as should it have legs to push off the ground like a kangaroo, or should it be more like an engineered piston with a giant spring? Should it be a simple symmetrical shape like a diamond, or should it be something more curved and organic? Then, after deciding this we need to think about the size of the robot – small robots are light and agile, but then large robots can carry bigger motors for more powerful jumps, so is the best option somewhere in the middle?

“Our structural redesigns redistribute the robot’s component mass towards the top and taper the structure towards the bottom. Lighter legs, in the shape of a prism and using springs that only stretch are all properties that we have shown to improve the performance and most importantly, the energy efficiency of the jumping robot.”

Although the researchers have found a practicable design option to significantly improve performance, their next goal is to control the direction of the jumps and find out how to harness the kinetic energy from its landing to improve the number of jumps the robot can do in a single charge. They will also explore more compact designs for space missions, making the robot easier to transport and deploy on the moon.

has been awarded an OBE for his services to public health, to epidemiology and to adult social care, particularly during Covid-19, has been awarded an OBE for his for services to the advancement of the science of radiation protection, Professor Paul Klapper has been awarded an OBE for services to viral diagnostic testing, and Professor Paul Howarth has been awarded a CBE for his significant contribution and service to the nuclear industry and to UK research and development (R&D).

The list celebrates individuals who have had an immeasurable impact on the lives of people across the country - such as by creating innovative solutions or driving real change in public life.

Ian Hall is a Professor of Mathematical Epidemiology and Statistics at The University of Manchester. He is a long-standing member of SPI-M (the pandemic disease modelling advisory group) and played a critical role in the operations of this group during the swine flu and Covid-19 pandemics.

During the Covid-19 pandemic he was academic chair of the SAGE working group of Social Care and participated in the SAGE Environmental Modelling Group as well as attending SAGE itself. He was also involved in a number of research projects, including the national core study on transmission () and Project TRACK to understand and control the risks on public transport. He also helped analyse data from a new heat map, providing a national picture of the spread over time.

Since the pandemic, Professor Hall has continued working with UKHSA through an honorary contract, notably with Health Equity Division on vaccination strategies in prison and homeless settings.

His other research interests include the impact of diseases on vulnerable populations and the study of vector-borne infectious diseases and environmental infections, such as Legionnaires Disease.

Richard Wakeford is an Honorary Professor in Epidemiology in the Centre for Occupational and Environmental Health (COEH), having been Professor in Epidemiology at the Centre before retiring at the end of 2019. He specialises in the epidemiology of exposure to ionising radiation, particularly as related to radiological protection.

Professor Wakeford is a member of various committees, including the UN Scientific Committee on the Effects of Atomic Radiation and the International Commission on Radiological Protection. He was a member of the Scientific Advisory Group for Emergencies (SAGE) following the Fukushima nuclear accident in Japan, and for 25 years was Editor-in-Chief of the Journal of Radiological Protection.

Richard completed his PhD in high energy physics at the University of Liverpool in 1978 and worked for British Nuclear Fuels Ltd (BNFL) for nearly 30 years. It was the many challenges faced at BNFL where he developed his skills in radiation epidemiology and radiological protection. He was privileged to work with Sir Richard Doll during this time. After taking early retirement from BNFL, Richard joined the University, initially through an association with Dalton Nuclear Institute and then joining COEH.

Paul Klapper is Professor of Clinical Virology at The University of Manchester. He began his career in virology in 1976 working as a laboratory technician at Booth Hall Children’s Hospital. He completed his PhD while working at 91ֱ�� Royal Infirmary on the diagnosis of herpes simplex encephalitis - a topic he continued to work on for over 20 years and led to the development of a reliable molecular diagnostic test for the condition. He also helped establish independent quality assurance testing in the infancy of viral molecular diagnostic testing. 

Throughout his career, Professor Klapper has been at the forefront of several key developments of viral diagnostic testing. Notably, he worked with the Greater 91ֱ�� Hepatitis C testing strategy, developing community-based testing methods to aid control of the HCV pandemic. In 1981, he became an NHS Clinical Scientist, working in both 91ֱ�� and Leeds as a Consultant Clinical Scientist. Ten years later, in 1991 became a Fellow of the Royal College of Pathology. 

On retiring from the NHS in 2012, Professor Klapper joined The University of Manchester as a Professor of Clinical Virology.  Early in 2020, he volunteered to help with establishment of large scale Covid-19 testing and became the clinical lead for the Alderley Park testing facility. He also served as a Clinical Advisor for testing with the Department of Health.

 Professor Klapper continues to conduct vital research in blood-borne virus infection and in congenital human cytomegalovirus infection.

Paul Howarth is Professor of Nuclear Technology at The University of Manchester and Chief Executive of National Nuclear Laboratory. 

Professor Howarth has had a distinguished career working in and for the nuclear sector, building a reputation as one of the leading figures in the UK nuclear sector and around the global industry. After completing his degree in Physics and Astrophysics and PhD in Nuclear Physics, he started his career working on the European Fusion Programme. Early in his career he was awarded a prestigious Royal Society Fellowship to work in Japan on their nuclear programme. On returning to the UK he continued to work on nuclear fission leading the UK’s advanced reactor programme while working at British Nuclear Fuels, co-founding the at the University  and working closely with UK Government on building the case for new nuclear build.

Professor Howarth was appointed CEO for the National Nuclear Laboratory (NNL) in 2011 following its creation as a public corporation, having been instrumental in its establishment from British Nuclear Fuels Limited (BNFL). During his tenure as CEO, NNL has been transformed into a successful business and a true national laboratory, delivering profits to reinvest into nuclear science and technology and critical support to nuclear organisations in the public and private sectors. 

The birthday honours are awarded by the King following recommendations by the prime minister, senior government ministers, or members of the public.

The awards recognise active community champions, innovative social entrepreneurs, pioneering scientists, passionate health workers and dedicated volunteers who have made significant achievements in public life or committed themselves to serving and helping Britain.

To see the full Birthday Honours List 2024, visit: https://www.gov.uk/government/publications/the-kings-birthday-honours-list-2024