Applications are now open for the second cohort of the: Greater 91ֱ��’s programme for researchers, technical founders and early-stage ventures turning scientific and engineering breakthroughs into investment-ready ventures. 7–10 ventures will be selected, with applications open to eligible teams across Greater 91ֱ��.

Delivered by Unit M, The University of Manchester's innovation unit, and backed by Greater 91ֱ�� Investment Zone funding, the programme runs from November 2026 to April 2027. Applications close 19 October 2026.

The deep tech accelerator is designed specifically for founders and researchers developing technologies rooted in significant scientific discoveries or engineering advances.

Unlike traditional startup programmes, it focuses on the unique challenges associated with commercialising deep tech innovations, helping participants navigate the journey from breakthrough research to investable business.

Many early-stage deep tech innovations need focused support to navigate the journey from research and development to commercial and societal impact.

Earlier in 2026, cohort 1 supported 10 deep tech ventures from across the University and the region working on next-generation health technologies, clean energy, advanced materials, agritech and space technologies.

Patrick Sarsfield, Founder and CEO of Graphene Thermal, and a member of the deep tech accelerator cohort #, said: “The Unit M deep tech accelerator is what we needed to prepare ourselves to be investment ready. All of the mentorship and guidance that we’ve had has come through the university support system. It’s really been at the centre of getting this business off the ground.”

Tim Bailey, Founder and CEO of WarmTronics, and a member of the deep tech accelerator cohort #1, said: “The accelerator helped us move forward in our commercialisation journey. Funding allowed us to do marketing and customer discovery that we initially wouldn't be able to afford. Off the back of that, we did an exhibition in London, we met with a major supermarket chain and we're now looking at trialling our products with them.”

Why apply?

Teams selected for cohort #2 of the programme will receive £25,000 in equity-free funding, alongside dedicated commercialisation support, access to specialist mentors and industry experts, customer discovery and market validation frameworks, and training on how to pitch effectively to investors.

Each venture will also benefit from support from experienced University of Manchester MBA students and the opportunity to present to investors and strategic partners at a dedicated demo day.

The programme is open to researchers, founders and spinouts from universities across Greater 91ֱ��, as well as technical founders from the region's wider deep tech community. Building on the success of the inaugural cohort, cohort #2 will place an increased emphasis on engaging teams from across the city-region, reflecting a continued commitment to strengthening Greater 91ֱ��'s deep tech ecosystem.

What is deep tech?

Deep tech refers to technologies built on significant scientific discoveries or engineering advances that create new capabilities and solve real-world problems.

Areas of interest for the programme include:

· Advanced materials and manufacturing;

· Quantum technologies;

· Artificial intelligence and data infrastructure;

· Biotechnology and health technologies;

· Climate and energy technologies;

· Robotics and automation;

· And space and aerospace technologies.

Who is eligible?

We are looking for teams or individuals based in Greater 91ֱ�� who are ready to spend six months building towards investment. We are looking for:

• Researchers whose work has commercial potential you haven't yet acted on, or
• Technical founders with a working prototype or early validation.

Not sure if you’re eligible? Come along to our on 29 September and 12 October or ask us directly by emailing community@unit-m.co.uk. Or join us at the on 7 October, during the Innovation Festival, where we will have a stand and can answer your questions.

Ready to apply?

Applications close 19 October 2026, with space for 7–10 teams in cohort #2.

Further details on eligibility, information sessions and the application process are available via the on Unit M’s website.

Key dates

• Applications close: 19 October 2026
• Information sessions: 29 September and 12 October 2026
• Programme delivery: November 2026 to April 2027

Why Greater 91ֱ��, why now?

The deep tech accelerator is part of a wider ambition to make Greater 91ֱ�� a leading hub for deep tech innovation, supported through the Greater 91ֱ�� Combined Authority’s (GMCA) Investment Zone funding. It is designed to help strengthen the region’s growing deep tech ecosystem by connecting founders with expertise, networks and opportunities for growth.

Bridging the gap between research and commercialisation, the programme provides the expertise, connections and support needed to help turn deep tech innovation into investable businesses with the potential for significant societal and economic impact.

Four 91ֱ�� academics made Fellows of the Royal Academy of Engineering

The Royal Academy of Engineering has today announced that four academics from The University of Manchester, Professors Danielle George, Alan Partridge, and Rich Curry, and Visiting Professor Kirsty Armer will be part of the newest cohort of leading figures in the field of technology and engineering to be appointed Fellows.

They will be joining the Academy in its 50th year and are part of a cohort of 75 new Fellows, who are making an incredible impact across the engineering and technology sector with innovations in clean energy, AI, medicine and public health; joining leading figures who have influenced academia and business, worked to widen participation in engineering for people from underrepresented backgrounds, and provided expert policy advice to government.

Professors George, Armer, Partridge, and Curry will be formally admitted to the Academy at a special ceremony in London on 19 October, when each Fellow will sign the roll book. In joining the Fellowship, they will lend their unique capabilities to achieving the Academy’s aim to engineer better lives.

Sir John Lazar CBE FREng, President of the Royal Academy of Engineering, said:

“This year’s cohort will be joining a community of over 1,700 top engineers and innovators in the UK and around the world. Together, we ensure that bright ideas are supported, scaled and shared, turning ambition into innovation and innovation into impact. We aim to strengthen education, skills and inclusion to inspire and equip the engineers of today and tomorrow.”

91ֱ�� Academics awarded prestigious Colin Campbell Mitchell Award

The Academy has also awarded Professors Barry Lennox (Electrical and Electronic Engineering) and Michael Fisher (Computer Science) the prestigious Colin Campbell Mitchell Award, given to a team of engineers who have made an outstanding contribution to the advancement of any field of UK engineering across the past four years. Visiting Professor Kirsty Hewitson was also part of the team receiving the Academy honour.

This year, it is given in recognition of the pioneering approach that the University of Manchester has been taking in its approach to developing robotic systems for deployment in hazardous environments.

Their work has delivered significant engineering, safety and economic benefits, including robotic deployments that reduce human exposure to dangerous environments, estimated savings of around £20 million for Sellafield and the Nuclear Decommissioning Authority, and a projected future value of £500 million through wider adoption of the technologies developed. They have also pioneered the use of digital twins and simulation environments to improve safety, training and operational efficiency, while contributing to the development of robotics policy and responsible AI practices in the UK and internationally.

Chair of the Academy’s Awards Committee, Luke Logan (FREng), said of the research,

"By translating robotics and AI research into real-world industrial applications, this team has transformed how hazardous and complex engineering tasks can be carried out. Their work is reducing risks to people, improving productivity and delivering substantial economic benefits across multiple sectors. Through an outstanding collaboration spanning industry, academia and the public sector, they have demonstrated how engineering innovation can deliver real-world impact."

In her role as Visiting Professor, Dr Hewitson will help to embed key principles for translating and commercialising innovations, as well as provide mentoring to underrepresented students, building industry links to provide future career opportunities.

Dr Hewitson, a distinguished expert in the translation and commercialisation of technologies across energy, defence and life science sectors, is visiting from the Robotics and Artificial Intelligence Collaboration (RAICo) – an end-user led collaboration between the UK Atomic Energy Authority (UKAEA), the Nuclear Decommissioning Authority, Sellafield Ltd, AWE Nuclear Security Technologies and The University of Manchester.

In her role at UKAEA and as Director of RAICo, Dr Hewitson oversees the development of robotics for nuclear decommissioning and fusion engineering, working with industry, academic and international partners to help remove people from hazardous environments and achieve safer, faster and more cost-effective solutions.

Prior to RAICo, Dr Hewitson had previously held positions as Chief Executive Officer at Innovate UK KTN, Vice-President of Strategy and Innovation at the National Nuclear Laboratory and Vice-President of Life Sciences at Ploughshare Innovations.

Dr Hewitson said of the announcement, “I feel privileged to have been appointed as a Royal Academy of Engineering Visiting Professor at the University of Manchester. I have seen first-hand how essential our relationship with academia is for connecting different ideas from different fields in ways that would not otherwise be apparent."

A new test to identify cells collected from urine and vaginal fluid could help rule out womb and other cancers in most women who experience bleeding after the menopause, find University of Manchester researchers.

Their study published in Lon 22/09/26 say the test could potentially reduce the need for invasive hospital investigations, easing anxiety during what can be a distressing time for many women.

The research team, also based at 91ֱ�� University NHS Foundation Trust (MFT) and supported by the National Institute for Health and Care Research (NIHR)Biomedical Research Centre (BRC): 91ֱ��, showed that the new test can detect womb cancer, also known as endometrial cancer, with high accuracy.

Postmenopausal bleeding currently triggers urgent investigation for possible cancer, often involving a series of uncomfortable, invasive and costly tests, even though most women will not ultimately receive a cancer diagnosis.

Further work from the group, also published in the same journal today, showed that current tests are poorly calibrated for people from Black ethnic backgrounds, leading to health inequalities in diagnosis, treatment and patient outcomes.

However, the new test was particularly effective at detecting aggressive and advanced cancers, and performed exceptionally well in Black women, who are twice as likely to die from womb cancer as White women in the UK.

The researchers say the new test could therefore help to reduce health inequities and improve outcomes for previously disadvantaged groups, including those who are unable to tolerate routine procedures.

The test could eventually be used in primary care and other community settings, helping speed up diagnosis and provide reassurance for many women.

Womb cancer affects nearly 10,000 women in the UK each year, but only 5–10% of women investigated for bleeding after the menopause will have cancer.

Despite that, most undergo invasive hospital tests that can be uncomfortable, costly and sometimes need repeating.

Previous studies led by 91ֱ�� researchers have suggested cancer cells can be detected in urine and vaginal fluid samples.

The DETECT study - as it is known - was designed to assess whether these simple, non-invasive tests could accurately identify women at risk while safely reassuring others.

The study involved 1,864 women attending hospitals *with postmenopausal bleeding, making it one of the largest evaluations of this approach to date.

Before having their routine clinical investigations, participants provided a urine sample and a vaginal fluid sample, which were examined for abnormal cells by specialist cytopathologists who did not know the women’s diagnoses.

A total of 115 women were found to have cancer, including 99 cases of womb cancer and a smaller number of other pelvic cancers.

When urine and vaginal cytology (cell sample) results were combined, the test correctly identified more than 80% of cancers and achieved a negative predictive value of 98.8% for womb cancer, meaning women with a negative result were highly unlikely to have the disease.

The vaginal test performed slightly better than the urine test alone, although both showed promising diagnostic accuracy.

The test detected almost all aggressive cancers, identifying 95.8% of high-grade tumours and 96.4% of cancers that had already spread beyond the uterus.

It also picked up 100% of cancers in Black women with 96% specificity, meaning that the test showed near perfect performance in this small subgroup of women.

The findings suggest the approach could become a valuable triage tool, helping clinicians decide which women need urgent invasive investigations while providing reassurance for many others.

Lead researcher Professor from The University of Manchester and Honorary Consultant in Gynaecological Oncology at MFT, said: “Bleeding after the menopause is understandably alarming for women because it can be a sign of cancer, but the vast majority of those investigated will not have the disease.

“At the moment, many women face invasive, uncomfortable tests that can be stressful as well as costly for health services before cancer can be ruled out.

“Our study shows that a simple test using urine and vaginal samples could help identify the women most likely to have cancer while safely reassuring many others much earlier in the diagnostic pathway.

“If further studies confirm these findings in routine practice, this approach has the potential to transform care for thousands of women every year.”

Prof Davidson, who is also Cancer Prevention and Early Detection Theme Co-Lead at the NIHR BRC: 91ֱ��, added: “Further studies are now needed to assess how the test would perform in routine clinical practice and whether it can reduce the number of invasive procedures women undergo.

“If successfully introduced into healthcare settings, the test could offer a faster, less invasive and more patient-friendly route to diagnosing womb cancer.”

• The study was funded by The Jon Moulton Charity Trust and the women were recruited from gynaecology clinics at seven hospital sites across North West England: St Mary’s Hospital, Trafford General Hospital, Wythenshawe Hospital, Royal Oldham Hospital, North 91ֱ�� General Hospital, Fairfield General Hospital and Tameside Hospital.
• The paper Urine and vaginal cytology for endometrial cancer detection in women with postmenopausal bleeding: the Developing Tests for Endometrial Cancer detection (DETECT) diagnostic accuracy study is available here: DOI https://doi.org/10.1016/

Publication details

The study was published in xxx journal.

DOI: http://xxx.

Three new Future Leaders Fellowships are empowering 91ֱ�� researchers to tackle very different scientific challenges – from predicting extreme ocean waves to designing miniature biological factories to wearable health technology that transcends health inequalities – with potentially far-reaching consequences.

Backed by a combined £5.4 million from UK Research and Innovation (UKRI), Dr Samuel Draycott, Dr Lukas Hughes-Noehrer and Dr Richard Obexer are among the recipients of its 2026 Future Leaders Fellowships (FLF) awards. The funding will support four years of ambitious research in fields spanning ocean engineering, biotechnology and digital enabled health.

The Future Leaders Fellowships: at a glance

• How well we understand the ocean matters increasingly for the infrastructure we build, the energy we generate and our response to climate change. is investigating what happens when waves break in the complex conditions found in the ocean, with real implications for how we design offshore wind farms and other marine infrastructure, and for improving the accuracy of climate and ocean models that predict how the sea absorbs and releases carbon dioxide and other gases.
• Across 91ֱ��'s communities, is taking research directly into patients’ homes – creating a real-world test environment to help make wearable health technologies a routine part of cancer care. He's working to discover whether continuous data from wearable devices can help NHS clinical teams support patients through cancer surgery, and how to make sure this new model of care reaches everyone, including those at risk of digital exclusion.

• Meanwhile, in another laboratory in 91ֱ��, has been looking at the world on a different scale – exploring how nature packages enzymes inside tiny structures in living cells. He’s working to discover whether those same principles can be engineered to manufacture medicines, recycle carbon and produce valuable chemicals more efficiently.

Dr Samuel Draycott: Wavebreak

Offshore wind farms, ships and other marine structures all need to withstand the most powerful waves the ocean can produce, but many engineering models simplify the sea in ways that don’t fully reflect real-world conditions. This potentially affects how accurately we can predict the forces these structures will face.��

Recent work by Dr Draycott and collaborators, published in Nature, . Through this fellowship, Dr Draycott and his colleagues will build on this research to recreate even more realistic ocean conditions in their laboratory, combining waves travelling in different directions with currents that change speed with depth, as they do in the real ocean.��

The team will study what happens when waves break and what happens in the seconds afterwards, including how they move particles such as microplastics and phytoplankton, draw air into the ocean and transfer gases such as CO2 between the sea and atmosphere. This could improve our understanding of everything from pollution and marine ecosystems to the ocean’s role in absorbing carbon from the atmosphere.��

Dr Draycott, Senior Lecturer in Ocean Engineering in the Department of Civil Engineering and Management, University of Manchester, said:��
“We’ve long relied on simplified models to understand how waves behave, but the real ocean is much more complex.

“This matters because engineers use estimates of extreme waves when designing offshore wind turbines, ships and platforms, so a better understanding of wave breaking could help us improve the safety and efficiency of this infrastructure. These are crucial industries, with the UK aiming to increase its offshore wind capacity to at least and a sector already employing tens of thousands of people .”��

The research, funded with £1.67m from UKRI, will take place in the University’s new Hydrodynamics Laboratory, using high-performance computer simulations and laboratory experiments to measure how waves break, how much air they draw into the water, and how they move particles.

Dr Lukas Hughes-Noehrer: 91ֱ�� Digital Health Living Lab

Wearable devices can monitor vital signs such as heart rate, activity and sleep, providing clinicians with valuable data to inform on-going patient care. The NHS 10 Year Health Plan identifies them as one of its “5 Big Bets” for transforming healthcare, but their use across the health service remains patchy, with benefits not reaching all communities equally. Through his fellowship, Dr Lukas Hughes-Noehrer will establish the 91ֱ�� Digital Health Living Lab, a real-world testbed where patients, families, community organisations, clinicians, researchers, industry partners, and local government work together to design and evaluate wearable-enabled care.

The £2.4m-UKRI funded programme is built around three strands. The first will work with communities to understand what helps or hinders people in adopting wearables, with a focus on accessibility, trust, usability and digital inclusion. The second will develop secure systems that connect wearable data to electronic health records and explore how continuous streams of patient-generated data can be transformed into clinically meaningful real-time information to support care. The third will embed a wearable-enabled clinical trial, working with approximately 800 patients undergoing lung and hepato-pancreato-biliary surgery to trial adoption and evaluate their potential to improve health outcomes.

Findings will help shape the future use of wearable technologies across healthcare and inform the development of digitally enabled hospitals and care pathways in Greater 91ֱ�� and beyond.

Dr Hughes-Noehrer, Lecturer in Mobile and Wearable Health Technology in the Division of Informatics, Imaging, and Data Sciences, and Lead for Computational Medicine at 91ֱ�� University NHS Foundation Trust said:

“As someone who works at the intersection of healthcare and research, I see first-hand how health inequalities can affect who benefits from new models of care and emerging technologies. Wearables have huge potential to provide more personalised, proactive support, but only if everyone can access, use and trust them. By working directly with our communities in 91ֱ��, I want to build a model for wearable-enabled care that is fair, safe and trusted, and that other places in the UK and beyond can follow.”

Dr Richard Obexer: De Novo Biomolecular Condensates for Programmable Assembly of Enzyme Cascades

Inside our cells are tiny droplets that act a little like miniature factories. Without being surrounded by a membrane, they can bring particular proteins and enzymes together, allowing chemical reactions to happen faster and more efficiently.

These structures known as ‘biomolecular condensates’, occur widely inside living cells, and Dr Richard Obexer is exploring whether we can recreate this natural trick, then engineer it to make useful products more efficiently.

His new fellowship, funded by £1.3m from UKRI, will enable him to combine AI-powered protein design with a laboratory process inspired by natural evolution, to rapidly test thousands of protein variations. The aim is to create molecules that can encourage these droplets to form around a much wider range of enzymes, while controlling what happens inside them. This could give researchers unprecedented control over the conditions inside each biological factory.

The team will initially test their approach by building a five-enzyme system to manufacture islatravir, an anti-HIV drug that’s currently made using conventional chemical synthesis. Next, they will explore whether a ten-enzyme system could turn CO2 and methanol into starch, potentially creating a route for converting captured carbon into useful materials. Finally, they’ll rebuild a biosynthetic pathway in bacteria to produce trunkamide, an anti-cancer compound that has proven difficult to manufacture at a useful scale.

Dr Obexer, BBSRC Discovery Fellow in Chemical Biology and Biological Chemistry, in the Department of Chemistry, University of Manchester, said:

“Nature has already evolved incredibly efficient ways of organising chemistry inside cells, and we’re now asking whether we can recreate and engineer these to build tiny biological factories for ourselves. If we can combine that with AI-designed proteins, we could make entirely new manufacturing processes possible, from medicines to ways of turning captured carbon into useful products.”

The University of Manchester and the Jeremy Coller Foundation have announced the finalists for the Coller AI Competition with one early-stage venture set to receive a £100,000 equity investment to help turn it’s responsible AI innovation into a growing venture.

The competition attracted applicants from student, colleagues and alumni and brings together the University’s research strength, entrepreneurial talent and commitment to responsible innovation. It aims to identify and support founders developing AI solutions that are not only commercially promising but designed to benefit people and society.

The shortlisted Teams are:

Health Equity Chain

Health Equity Chain is building the Treatment Analyser System, an AI tool that helps doctors and patients make better prostate cancer treatment decisions. It shows a patient where they stand among people like them, making complex clinical information clear, understandable and equitable.

LanthaGen Bio Ltd

LanthaGen Bio has built an AI platform that simulates how biomolecules (proteins and peptides) bind metals, so new metal capturing proteins can be designed on a computer instead of found by trial and error. By drastically shortening the process it removes the energy, chemicals, plastic and solvent waste that repeated screening consumes.

SporeSense

SporeSense has built an AI-powered early-warning system that detects crop disease before any symptoms are visible. This lets farmers act early, cutting crop losses, reducing unnecessary pesticide use, and supporting more resilient, sustainable food production as climate change increases pressure on global agriculture.

SenseVale

SenseVale makes smart glasses that help blind and partially sighted people independently navigate their surroundings with minimal assistance. Sensors in the frame pick up what is around you, and the glasses tell you what they find through sound and vibration.

Forkprint Ltd

Forkprint is developing AI-enabled models that analyse any given food business’ data, such as recipes, menus and supplier information, to provide accurate greenhouse gas emissions GHGE information. This will enable food service businesses to assess and track the GHGE coming from their ingredients and food preparation processes, as well as rapidly develop lower-carbon recipes.

The initiative forms part of The University of Manchester’s Challenge Accepted campaign, which supports ideas with the potential to tackle major global challenges.

The Coller AI Competition is supported by the Jeremy Coller Foundation, the philanthropic vehicle of private equity entrepreneur Jeremy Coller. The Foundation supports initiatives focused on education, entrepreneurship, pensions innovation and the transition to a more sustainable food system. By supporting ambitious ideas, the Foundation helps drive lasting change and empowers the next generation of innovators and problem solvers.

The winner will be announced at The University of Manchester Innovation Festival on the 9^th of October 2026.

The University of Manchester Innovation Festival takes place Monday 5th October to Friday 9th October 2026

/collaborate/innovation-festival/events/?utm_source=insider&utm_medium=digital_newsletter&utm_campaign=innovationfestival26

The three-year appointment will support research, teaching and knowledge exchange at the intersection of artificial intelligence, creative practice, copyright and digital provenance. It builds on a collaboration initiated through Creative 91ֱ��, beginning with Melchior’s two-day visit to the University in May 2026.

An artist, composer and creative technologist, Melchior has spent more than 25 years exploring how music, science and emerging technology can reshape creative experience. His projects range from pioneering an artist website with David Bowie and helping shape Björk Digital and the Vulnicura VR album, to Massive Attack’s Fantom app and Mezzanine DNA experiment. He is founder of Genotone and creator of The Logos, a cathedral-scale collaborative installation with MIT that transforms signals from deep space into spatial sound.

He also advises UK government technical working groups on AI and copyright convened by the Department for Culture, Media and Sport and the Department for Science, Innovation and Technology. In this work, he represents organisations whose combined membership includes around 30,000 artists: the Music Managers Forum, Featured Artists Coalition and Association for Electronic Music.

Building on “Proof of Human”

Creative 91ֱ�� welcomed Melchior to the University in May 2026 for a programme of public engagement, student learning and interdisciplinary exchange around AI and creative authorship. Colleagues from Computer Science, Law and Humanities joined representatives from Greater 91ֱ��’s creative sector to explore the challenges and opportunities generative AI presents for the creative and intellectual property sectors.

At the centre of the visit was “Proof of Human: AI, Copyright, and the Fight for Creative Authorship”, a public lecture held at SISTER in 91ֱ��’s innovation district. Melchior examined how creative work can be attributed, protected and rewarded as generative AI becomes more widely used, making the case for reliable systems that verify authorship and trace the provenance of creative material.

He also led a masterclass for undergraduate and postgraduate music and composition students on moving music from studio to release while maintaining provenance and control of intellectual property. The visit created opportunities for collaboration across Computer Science, the School of Law and the School of Arts, Languages and Cultures.

Connecting expertise across disciplines and sectors

As Honorary Professor, Melchior will work with colleagues across the University over the next three years to develop research, teaching and knowledge exchange focused on AI, creativity and authorship. He will contribute to collaborative research into provenance technologies and their practical application within creative ecosystems, helping to translate emerging technical approaches into policy, industry and cultural contexts.

He will also support student learning through guest lectures, workshops and the co-supervision of PhD projects. The appointment will help shape interdisciplinary opportunities connecting computing, music, law, archives and public policy, while providing a foundation for future funding bids and longer-term partnerships in responsible and trustworthy AI.

September visit and podcast

Melchior will return to the University from 21-25 September 2026 for an engagement programme celebrating his new role. He will deliver a seminar for the Department of Computer Science and take part in research and knowledge exchange meetings with colleagues from across the University. The programme will explore potential collaborations connecting computing, the creative industries, policy and the cultural sector.

The visit will coincide with the release of a podcast episode on creative ownership, featuring Melchior in conversation with Parvathy Nair, a postgraduate researcher in AI and patent law. Part of a series on the ethics of AI in the cultural and creative industries, the episode considers how artists can retain ownership of their work within the current technological and regulatory landscape.

Supporting 91ֱ�� 2035

The collaboration aligns with From 91ֱ�� for the world, the University’s strategy to 2035. The strategy seeks to define what a great university looks like for the 21st century by creating knowledge for the public good, locally and globally. By connecting computer science with the creative industries, cultural organisations, law and policymaking, the appointment supports the University’s commitments to interdisciplinary research, partnership, responsible AI and translating research excellence into practical impact.

“Creative work is becoming fluid. It can be copied, transformed and recombined at machine speed, while authorship and ownership struggle to keep up,” said Andrew. “This appointment is an opportunity to bring computer scientists, artists, lawyers and policymakers together to build practical systems that keep identity and provenance attached to creative work.”

"I am delighted to welcome Andrew Melchior as Honorary Professor in Computer Science here in 91ֱ��," said Professor Andrew Stewart, Head of the Department of Computer Science. “He has a unique perspective at the intersection of AI, provenance, and creativity drawn from deep technical knowledge. Andrew’s particular lens is critical in helping us navigate the AI challenges and opportunities we face with respect to creative authorship. I very much look forward to his research collaborations and teaching contributions, both within the Department of Computer Science and, more broadly, across our University.”

Andrew has a remarkable ability to bridge worlds that do not always naturally come together, from computer science and policy to music, the arts and the creative industries," said Professor Michelle Phillips, Director of Creative 91ֱ�� and Professor of Music. “At a time when artificial intelligence is reshaping how creative work is produced, shared and valued, his expertise offers an important perspective on how we can protect and support human creativity.”

“His visit to 91ֱ�� earlier this year sparked valuable conversations between researchers, students, policymakers and creative practitioners, demonstrating the potential for genuinely interdisciplinary collaboration. We are delighted to build on that momentum through this appointment and look forward to developing new research, learning and engagement opportunities together over the coming years.”

Around one million people are living with dementia in the UK, yet more than a third do not have a diagnosis. Dementia risk is shaped by a mix of health, lifestyle and environmental factors, but there are positive steps people can take to reduce their risk.

The 91ֱ�� Brain Health Centre (MBHC) has been spearheaded by Alzheimer’s Society in partnership with 91ֱ�� University NHS Foundation Trust, Greater 91ֱ�� Mental Health NHS Foundation Trust, The Geoffrey Jefferson Brain Research Centre at The University of Manchester and supported by NHS Greater 91ֱ��.

MBHC is a unique joined-up, single service bringing together psychiatrists, vascular specialists, clinical academics, and a multidisciplinary team to identify and support people at the earliest stages of memory loss. People will benefit from advanced diagnostic techniques such as MRI scans, lumbar punctures, heart health checks, and behavioural assessments, delivering an earlier and accurate diagnosis. This approach will also help identify underlying risk factors and inform the most effective treatment and support plan for individuals.

People who meet the requirements for the MBHC will be identified through existing memory assessment services and referred directly. Those who take part in the two-year pilot in central 91ֱ�� will also be given the chance, if they are eligible, to take part in research and clinical trials.

Alzheimer’s Society Brain Health Advisers will work alongside NHS clinicians to offer personalised support, guidance and information to people with mild cognitive impairment (MCI), an early stage of memory and thinking changes, or dementia, as well as to anyone looking to improve their brain health through achievable lifestyle and health changes.

Michelle Dyson CB, Alzheimer’s Society Chief Executive Officer, said: “Dementia is the UK’s biggest killer, but it is not an inevitable part of ageing. Nearly half (45%) of dementia cases worldwide could be prevented or delayed by addressing health and lifestyle factors, throughout our lives, like high blood pressure.

“If we can identify people early enough, we can significantly improve their brain health and help put the brakes on dementia. The 91ֱ�� Brain Health Centre really is changing the game, and we are proud to be a partner. This model could be replicated in other regions, transforming the future for thousands of people at risk of dementia or in the early stages of memory loss.”

Professor Adam Greenstein, Consultant Geriatrician at 91ֱ�� University NHS Foundation Trust, Clinical Scientist at University of Manchester and Alzheimer’s Society Ambassador, said: “The 91ֱ�� Brain Health Centre is a game-changing approach which brings together partners who believe that greater collaboration can help diagnose more people at an earlier stage and improve health outcomes. We are combining clinical and research expertise to identify people earlier, address risk factors such as high blood pressure, and support patients to live better for longer.

This is an innovative step towards a proactive approach to brain health, and we are creating a model which we believe could be adopted more widely. Through this pilot, we will be generating the evidence to support future service collaboration and development by clinical, research and academic teams across the country.”

Dr Ross Dunne, Consultant Later Life Psychiatrist and Dementia Research Lead at Greater 91ֱ�� Mental Health NHS Foundation Trust, said: “The 91ֱ�� Brain Health Centre is crucial to advancing our understanding and treatment of the diseases that cause dementia. Right now, the system is not set up for people when memory and thinking problems first appear. That is exactly when early diagnosis and treatment could have the greatest impact.

“We want the UK to be the best place in the world to get an early and accurate diagnosis. We can be a world leader in the research that will change the future of dementia. Together with our partners in Greater 91ֱ�� and Alzheimer's Society, our aim is to develop a model for brain health clinics nationwide.”

The 91ֱ�� Brain Health Centre’s pilot clinic is hosted at the National Institute for Health and Care Research (NIHR) Clinical Research Facility (CRF): 91ֱ�� at 91ֱ�� Royal Infirmary.

• The 91ֱ�� Brain Health Centre reflects The University of Manchester's commitment through its Challenge Accepted��campaign to bring together research, healthcare and communities to address some of society's most pressing challenges, including improving health outcomes and healthy ageing.
• If you’re worried about yourself, or someone close to you, then Alzheimer’s Society’s symptom checklist can help you start a conversation with a GP. Visit alzheimers.org.uk/checklist or call their Dementia Support Line on 0333 150 3456.

Women with a higher Body Mass Index in early adulthood may have a lower risk of developing breast cancer after the menopause because of lasting changes in the structure of their breast tissue, according to researchers at The University of Manchester and 91ֱ�� University NHS Foundation Trust.

An analysis of data from more than 33,000 women found that breast density could partially explain the link between a higher body weight at age 20 and a lower chance of post-menopausal breast cancer.

The findings help explain a long-standing puzzle in breast cancer research: being overweight in middle age is known to increase breast cancer risk, while a higher body weight in childhood, adolescence and early adulthood appears to have the opposite long-term effect.

The study is published in the British Journal of Cancer today (17/09/26) and is supported by the National Institute for Health and Care Research (NIHR) Biomedical Research Centre (BRC): 91ֱ��.

The researchers followed 33,816 women taking part in the UK Predicting Risk of Cancer at Screening () programme for more than a decade and recorded 1,261 cases of post-menopausal breast cancer.

They examined women's self-reported body mass index (BMI) at age 20 and compared it with measurements of breast density taken during routine mammograms.

Breast density refers to the amount of fibrous and glandular tissue in the breast compared to fatty tissue; women with denser breasts are known to face a higher risk of breast cancer.

The team found that the women who had a higher BMI at age 20 generally had lower percentage breast density later in life and were also less likely to develop post-menopausal breast cancer.

For every five-point increase in BMI at age 20, the risk of developing post-menopausal breast cancer fell by around 15 per cent. Further analysis suggested that lower breast density may account for almost 60 per cent of this effect.

The researchers believe the timing of body weight gains may be crucial because women’s breasts are still developing during adolescence and early adulthood, potentially leading to long-term changes in tissue structure.

The study also found that different measures of breast density may reflect different biological pathways linked to breast cancer risk.

One measure, which estimates the percentage of dense tissue within the breast, appeared to capture some of the lasting effects associated with higher body weight in early adulthood. Another measure based on the total volume of glandular tissue appeared to be more strongly influenced by body weight later in life.

First author Dr Benoit Jauniaux, a Surgical Trainee in the North-West Deanery said: "Researchers in previous studies have observed that women with a higher BMI in childhood or their early adulthood appear to have a lower risk of breast cancer after the menopause, but we have not fully understood why.

“This study suggests that downstream changes to breast density may explain a large part of this effect.”

Senior author Professor Andrew Renehan, Professor of Cancer Studies and Surgery at The University of Manchester and Programme Co-Lead in the Cancer Prevention and Early Detection Theme at the NIHR BRC: 91ֱ��, added: “These findings do not suggest that gaining weight is protective. What they offer is further insight into how breast tissue and consequent breast cancer risk may be shaped across a woman's lifetime – and we want to understand these mechanisms further.

“Maintaining a healthy weight remains important, because excess weight in later adulthood is linked to a higher risk of breast cancer and many other serious diseases.

“But this study adds to growing evidence that exposures during early life can have lasting effects on health decades later.”

• The paper Early-adulthood body mass index, mammographic density and post-menopausal breast cancer risk: a mediation analysis is published in the British Journal of Cancer and is available here. DOI

Using the European Southern Observatory's Very Large Telescope (VLT) in Chile, researchers, involving scientists from The University of Manchester and The Valongo Observatory, studied Sakurai's Object, a rare ‘born-again’ star that unexpectedly burst back to life in 1996 after reaching the final stages of its evolution.

Their findings, published today in , show that the star has entered a new phase of its evolution, developing the powerful stellar wind characteristic of Wolf-Rayet stars.

The research provides new insight into the final stages of stellar evolution and helps astronomers test theories that would otherwise take thousands or millions of years to verify.

Professor Albert Zijlstra from Jodrell Bank Centre for Astrophysics at The University of Manchester, said: "Most stars evolve so slowly that major changes take place over timescales far longer than a human lifetime. As a result, we usually have to piece together snapshots of stellar evolution by comparing different stars at different stages of their lives.

"Sakurai's Object offers something far rarer. It is one of the very few stars known to have changed dramatically within just a few decades, giving us the opportunity to watch stellar evolution unfold in real time.

“With our observations, we can test theories of how stars evolve and gain new insights into one of the shortest and least understood phases in the life of a dying star."

How a dead star burst back to life

The scientists believe the star was similar to our Sun, but had already ended nuclear burning and begun its journey towards becoming a white dwarf - the hot, dense core left behind after an ordinary star dies. It underwent a rare event known as a "very late thermal pulse", when a layer of helium deep inside the dead star suddenly reignites.

The event caused the star to rapidly expand, cool and eject large amounts of material into space, temporarily returning to an earlier stage of its life, leading astronomers to describe it as a "born-again" star.

Only two stars have ever been directly observed undergoing this type of dramatic rebirth: Sakurai's Object and V605 Aquilae.

Following its outburst, Sakurai's Object became hidden behind thick clouds of gas and dust released during the eruption, making it difficult to study directly.

To investigate its current state, the team analysed light collected by the Very Large Telescope and compared it with sophisticated computer models that simulate the atmospheres and powerful winds of Wolf-Rayet stars.

The observations revealed distinctive signatures of carbon and helium, allowing the researchers to find its temperature, chemical composition and the characteristics of its stellar wind.

Their analysis suggests the star's surface temperature is currently between around 27,000 and 36,000 degrees Kelvin, showing that it is reheating following its dramatic eruption nearly three decades ago.

A rare glimpse of stellar evolution in action

Prof Zijlstra added: "One of the key questions is how quickly Sakurai's Object should recover after its dramatic eruption.

"Our measurements show that the star is reheating more gradually than some earlier models predicted. That gives us an important way of testing which theories best describe what happens when a dying star briefly springs back to life.

"As we continue to monitor the star over the coming years, we expect to learn much more about this remarkable phase of stellar evolution."

The findings also suggest that Sakurai's Object is at an earlier stage of its evolution than V605 Aquilae, which experienced a similar event around 80 years ago.

The team will continue observing Sakurai's Object as it continues reheating and resumes its journey towards becoming a white dwarf, learning more about one of the most rapid and unusual phases of stellar evolution ever observed.

The University of Manchester has been recognised for the strength and breadth of its subject-level performance in the 2026 ShanghaiRanking’s Global Ranking of Academic Subjects.

The results reflect the depth of Manchester’s impact across a wide range of disciplines. Ten subjects are ranked among the top 50 worldwide, including five in the global top 25 across each of the University’s faculties. Geography remains in the world top 10, while Dentistry and Oral Sciences is ranked 13th, Physics 16th, Metallurgical Engineering 18th and Textile Science and Engineering 25th.

Completing the University’s global top 50 subjects are Biotechnology, ranked 29th, Mechanical Engineering 40th, Sociology 46th, Library and Information Science 48th and Political Sciences 50th.

Professor Duncan Ivison, President and Vice-Chancellor of The University of Manchester, said: “These results are a welcome recognition of the quality and reach of academic work taking place across The University of Manchester, with top 25 subjects spanning all three faculties.

“Rankings don’t measure everything we value, but are useful tools for reflecting on where progress is being made and where further work is needed, particularly in an increasingly competitive global higher education environment. The real value lies in using that insight to drive meaningful improvements in research, teaching and innovation, helping us deliver on our ambitious strategy - 91ֱ�� 2035”

Several subjects have climbed the table in this year’s rankings. Sociology returned to the global top 50, rising from the 101–150 band to 46th. Textile Science and Engineering moved from 30th to 25th, while Biotechnology rose from 33rd to 29th. Mechanical Engineering improved from 43rd to 40th.

Other areas also recorded progress. Mathematics, Artificial Intelligence and Psychology all saw substantial gains in the rankings, while Civil Engineering and Communication also improved.

The longer-term picture shows sustained momentum in several disciplines. Biotechnology has moved from the 151–200 band in 2023 to 36th in 2024, 33rd in 2025 and 29th this year. Mechanical Engineering has progressed from 76–100 in 2023 to 40th in 2026. Mathematics has improved in each ranking since 2023, moving from 151–200 to 51–75.

The University is now ranked in 49 subject areas, compared with 48 in 2025 and 43 in 2023. The results span disciplines across Natural Sciences, Engineering, Life Sciences, Medical Sciences and Social Sciences, reflecting the breadth of activity taking place across 91ֱ��.

ShanghaiRanking’s Global Ranking of Academic Subjects assesses universities across 57 subjects using nine objective indicators covering faculty, research output, research quality, impact and international collaboration.

Each year, the ranking includes subjects from approximately 2,000 universities across some 100 countries and regions.

For more information, visit the website.

The results demonstrate renewed momentum in the commercialisation of research originating from The University of Manchester (UoM), as the institution puts increasing focus on innovation as part of its ambitious 2035 Strategy.

As the University's dedicated technology transfer office, the Innovation Factory works with researchers to develop early-stage ideas, helping identify commercial potential, protect intellectual property and determine the best route to market. Its support continues through licensing and spinout creation, investment readiness and the longer-term development of companies within its portfolio.

The 11 new spinouts reflect the breadth of research and innovation taking place across the University:

• Grid Stability Ltd, building AI-driven stability assessment tools for modern power systems, reducing cost and carbon while improving stability.
• Lutèo Medical Ltd, developing new clinical eczema solutions based on microbiome science.
• SpinOr Ltd, pioneering a compact and modular superconducting quantum computer design.
• Imprinted Diagnostics Ltd, developing rapid diagnostics, with its first product focused on heart attack triage.
• ColoriQuo Ltd, developing sustainable structural colour technologies inspired by nature.
• FLAG-Me SAFE Ltd, creating digital safeguarding tools to help pharmacies better support people with sight and hearing impairments.
• Pacentrica Ltd, creating digital technologies for pain assessment and long-term pain management.
• Precica Ltd, developing technology to significantly reduce data storage requirements while keeping information searchable and accessible.
• InformiX Pharma Ltd, using advanced three-dimensional imaging to improve the development and manufacture of medicines.
• Zenithym Ltd, commercialising semiconducting polymer nanoparticles for a range of industrial and medical applications.
• C3 Biotechnologies Ltd, converting industrial waste streams into sustainable chemicals and high-value products.

Dr Catherine Headley, CEO of the University of Manchester Innovation Factory, said:

“This has been an incredible year for the Innovation Factory and the results reflect the breadth and quality of innovation emerging from across the University, the strength of our spinout portfolio, and the quality of service that we provide. We are extremely proud of the progress that we have made this year as we build the foundations to play a key role in the University’s innovation plans.”

Investment and the next generation of opportunities

Companies across the Innovation Factory portfolio secured over £56 million in external investment during 2025/26, providing crucial capital needed to develop technologies, attract talent, establish partnerships and move towards commercial scale.

Alongside supporting its established spinout portfolio, the Innovation Factory continues to develop the pipeline of opportunities that could become the University’s future spinouts and licenses.

During 2025/26, the team supported over 300 researchers from across the University’s schools and faculties at the early stages of commercialisation, helping them explore opportunities to create positive impact, develop intellectual property strategies and identify the most appropriate commercial outcomes for their research. This represents the highest level of researcher engagement with the Innovation Factory in five years, reflecting significant growth in the number of individuals accessing commercialisation support.

Professor John Holden, Vice President for Innovation and Civic Engagement said:

“Commercialisation is an important part of translating research into wider economic and societal benefit and positive impact. These results show the value of the rich innovation ecosystem that we are establishing in 91ֱ�� and the expertise within the Innovation Factory allows us to support our researchers from the earliest stages.”

A growing innovation ecosystem

The Innovation Factory’s work is increasingly enhanced by a wider innovation ecosystem across the University and Greater 91ֱ��.

In addition to the support from the Innovation Factory, staff, students and alumni can benefit from varied UoM specialist services and programmes including Unit M, Business Engagement and Knowledge Exchange and the Masood Entrepreneurship Centre, alongside initiatives such as Ideas with Impact, developed by the University’s Division of Development and Alumni Relations.

To find out more about the Innovation Factory, visit

Students will have the chance to take part in exchanges and gain a broader international perspective, while academic colleagues will be able to develop shared research interests and learn from each other’s approaches.

The two universities will collaborate through workshops and conferences, alongside sharing publications, teaching practice and course design.

ASU is consistently ranked as the most innovative university in the United States by U.S. News & World Report, taking the accolade for the 11^th successive year in 2025.

Professor Angelia Wilson, Associate Vice President International at The University of Manchester said: “We are strengthening the ties between these two powerhouses of innovation through this partnership, which will create incredible opportunities for colleagues and students on both sides of the Atlantic. The MoU sets a framework to build on our respective strengths and collaborate effectively over the years to come.”

Professor Fiona Devine, Vice President and Dean for the Faculty of Humanities at The University of Manchester added: “We are delighted to develop further opportunities to collaborate between the two institutions and build on our mutual research interests in innovation and policy across Humanities.”

Shannon Portillo, director of the School of Public Affairs and Coor Presidential Chair at Arizona State University said: “This MoU builds on the strong collaborations between faculty and research centers at 91ֱ��’s Faculty of Humanities and ASU’s School of Public Affairs. We look forward to more connections between our faculty and students.” The school is based in the Watts College of Public Service and Community Solutions at Arizona State University.

The University of Manchester is globally recognised for its research, teaching and commitment to social responsibility. It is an international university, with more than 46,000 students, 12,800 colleagues and 585,000 alumni from 190 countries.

Sign up for our e-news to hear first-hand about our international partnerships and activities across the globe.

The challenge, now in its third year, saw teams of Year 10 and 11 pupils spend four weeks developing metal-detecting robotic systems before returning to the University's Nancy Rothwell Building for a series of live detection challenges.

The competition is inspired by research carried out by the University's electromagnetic sensing team and gives young people hands-on experience of electronics engineering while highlighting the real-world challenge of detecting buried landmines and other hidden objects underground. It also aims to inspire more young people to consider careers in science, technology, engineering and mathematics (STEM).

Teams started with an introductory workshop in June, where they received their robot kits and took part in practical engineering sessions, careers talks and got the chance to meet and ask questions to professionals from across the electrical engineering sector. They were then paired with University of Manchester undergraduate mentors, who visited their schools to help guide teams through the design and build process.

The competition culminated in a final event on 14 July, with pupils putting their creations to the test in a series of practical arena challenges designed to assess their detection and engineering skills.

Co-op Academy Swinton took first place overall. St Ambrose Barlow RC High School were named runners-up and Chorlton High School South received the award for ‘Best Presentation’, all receiving specially engraved trophies.

Competition led, Dr Michael O’Toole said: “91ֱ�� Minesweeper challenge gives pupils the chance to take on a genuine engineering challenge and build something that works in the real world.

“Over the course of four weeks, they learn about electronics, problem-solving, teamwork and design, while working alongside current engineering students who help them develop their ideas and gain confidence that university and a career in STEM could be within their reach."

InstMC Vice-President Dave Green said: “It's incredibly rewarding to see the creativity, determination and technical skills that the teams develop, and we hope the experience encourages some of them to consider studying engineering or another STEM subject in the future.”

The initiative was originally established with support from a Royal Academy of Engineering Ingenious award. For the first time this year, it was supported by leading local engineering businesses through the sponsorship of the Institute of Measurement Control (Central Northwest), Endress+Hauser, Technical Partners, and Tetra Tech Consulting, whose representatives joined the final event and helped judge the competition.

will receive £95 million for research into advanced materials to help deliver the National Materials Strategy, launched in February 2026.

The Royce will continue its world-leading work to keep the UK at the forefront of advanced materials research and turn scientific discoveries into commercial products. The institute's work helps to create solutions to some of the key issues facing our society, including developing lighter, more efficient battery technology or using AI to design a new alloy that could replace scarce rare-earth materials used in electrical equipment. It works closely with businesses to commercialise new tech quickly and fuel growth in the UK.

The Rosalind Franklin Institute, a research centre dedicated to developing new technologies to address health challenges, will also receive a £67.7 million investment to build on its pioneering work in next-generation imaging, engineering, biology and diagnostics.

Science Minister Chris McDonald said: “We have world leading science research in the UK that pushes the boundaries of knowledge. It is the foundation of our mission to reindustrialise the country, creating good, well paid jobs by developing new technologies and growing British companies.

“The Rosalind Franklin Institute and the Henry Royce Institute are world leading in their fields. Combining biological knowledge, advanced physics and materials development to understand how the cells in our bodies function, and can be repaired and treated with precision medicines.

"The research gives our country a competitive edge, so long as we commercialise it in industry. Developing new medical technologies and treatments and bringing them to market is good for jobs and good for health, making a real impact on people's lives."

Turning research into reality

Executive Director for the Strategy Directorate at the Engineering and Physical Science Research Council (UKRI), Dr Kedar Pandya, said: “The Rosalind Franklin Institute and Henry Royce Institute have a proven track record of turning public investment into research that advances knowledge, improves lives and drives growth.

“This continued funding from UKRI builds on that success. It will give researchers the tools and resources to answer some of the biggest questions in the health and advanced materials industries, keeping the UK at the forefront of global science and engineering.”

These two institutes are turning brilliant science into real-world impact, and contributing to the UK’s leadership in two vital sectors – life sciences and the advanced materials industry, both of which are among the eight high growth sectors targeted for support in the government’s Industrial Strategy.

Their world-leading facilities, anchored at Harwell in Didcot for the Franklin and 91ֱ�� for the Royce, will provide new equipment and infrastructure for scientists, industry partners and as well as working closely with businesses across the country.

Already, Royce’s battery development facility has supported Molyon, a University of Cambridge spin-out, in creating a new generation of lithium-sulphur batteries that are lighter, more sustainable and can store twice as much energy as current models. The breakthrough has helped Molyon raise $4.6 million in seed funding to bring the technology to market.

This is just one example of how these institutes support connections between cutting edge research and British businesses, helping to make sure that the UK’s scientific excellence translates into jobs, new investment and economic growth in every part of the country, as set out in the government's 10-year Industrial Strategy. This funding is delivered through UK Research and Innovation, with the intention to deliver the greatest possible impact.

Professor Paul Monks, Chair, Henry Royce Institute said: “The achievements of the Henry Royce Institute demonstrate what can be accomplished when the UK brings together outstanding people, facilities and institutions around a shared national purpose, but ultimately the measure of our success is in the outcomes that this enables.

“This renewed investment is both a recognition of what the Royce Partnership has achieved and a huge vote of confidence in its future. Advanced materials underpin almost every technology that will shape a more sustainable and prosperous economy, and our next phase will be increasingly focused on translating our national capability into tangible outcomes for the economy, society and the environment.

“By deepening our national and international impact and forging stronger connections between research and industry, we want to ensure that great materials science leads to real-world innovation, while keeping the UK at the forefront of advanced materials.”

Professor Sarah Sharples, Vice-President and Dean of the Faculty of Science and Engineering and Member of the Royce Governing Board, said: "We are living through a period of profound technological and societal change, and meeting the challenges and opportunities that brings depends on strong partnerships between universities, industry and government.

"Royce demonstrates the power of that approach. By bringing together outstanding expertise, facilities and industrial partners from across the UK, it has built a world-leading advanced materials innovation ecosystem that translates extraordinary research into the technologies and businesses that will shape our future.

"As the lead partner and home of the Henry Royce Institute, The University of Manchester is proud to play a convening role at the heart of this national partnership and all it has achieved. This renewed investment will strengthen the UK's position as a global leader in advanced materials and help ensure that discoveries made in our laboratories continue to deliver benefits for the economy, society and the environment."

A new Wellcome Trust clinical Doctoral Training Programme partnership between The University of Manchester, City St George’s, The University of Exeter and Imperial College London, is enabling students to carry out cutting-edge research into fungal infections and address underrepresented populations and diseases. The Wellcome Trust is a global charitable foundation established in 1936 with an aim of working towards a healthier future for everyone. Through a £155 million investment into 14 new doctoral training programmes across the UK, Wellcome is supporting the next generation of healthcare professional researchers.

Tackling the global threat of fungal disease

The Mycology Doctoral Training Programme (Myco-DTP) will develop the next generation of clinical academic leaders tackling fungal diseases, one of the world's most significant but often overlooked infectious disease challenges.

Fungi such as Candida, Aspergillus and Cryptococcus cause more than six million invasive infections and over three million deaths globally each year, particularly affecting people with weakened immune systems. Treatment options remain limited and antifungal resistance is an increasing concern.

Although the UK is internationally recognised for excellence in medical mycology research, there is a shortage of clinically trained researchers able to translate laboratory discoveries into improvements in patient care. Myco-DTP has been designed to address this gap by supporting doctors, pharmacists and healthcare scientists to become future leaders in fungal disease research. Led by Professor Tihana Bicanic at City St George's, alongside Professor Adilia Warris at the University of Exeter, Professor Mike Bromley at the University of Manchester and Professor Darius Armstrong-James at Imperial College London, the programme will train 15 healthcare professionals through a multidisciplinary curriculum spanning five translational research themes of mechanisms of disease, diagnosis, immunology, therapeutics and antifungal resistance. PhD fellows will benefit from training, mentoring

and networking opportunities within an internationally recognised UK medical mycology community.

The programme brings together leading experts in fungal disease research and is linked to international networks focused on clinical trials, policy and advocacy, helping ensure discoveries made through the programme can deliver impact for patients in the UK and around the world.

Professor Bromley said: "Fungal infections are a growing global health threat, but clinical research capacity has simply not kept pace. The MYCO-DTP will be transformational, training a new generation of clinical researchers capable of translating world-leading fungal science into benefits for patients. Building on Wellcome’s sustained investment in medical mycology, and the combined expertise at the University of Manchester and National Aspergillosis Centre, this programme will help create the clinical research leaders our field urgently needs.”

Fatty liver disease, they find, has been overlooked in current approaches to assessing cardiometabolic health, despite growing evidence that it can play a central role in facilitating damage across different organs.

The condition which affects up to one in three adults worldwide and known technically as metabolic dysfunction-associated steatotic liver disease (MASLD), is already one of the world's fastest-growing health problems and is expected to affect more than half of adults globally by 2040.

Many scientists argue that the liver should be recognised alongside the heart, kidneys and metabolic system in a new framework they call cardiovascular-renal-hepatic-metabolic (CRHM) syndrome.

The review, published in Current opinion in nephrology and hypertension, highlights evidence showing that people with fatty liver disease face increased risks of cardiovascular disease, chronic kidney disease and early death, particularly when liver scarring, known as fibrosis, develops.

The studies they assessed, which involved millions of patients, found that fatty liver disease can predict heart and kidney complications independently of traditional risk factors such as diabetes, high blood pressure and obesity.

And having both liver and kidney disease appears to create a particularly dangerous combination.

A fatty liver releases substances into the bloodstream that promote inflammation, damage blood vessels, interfere with how the body uses energy.

That can influence the health of other organs through harmful fat deposits, chronic inflammation, hormonal signalling and changes in the gut microbiome amongst other things.

The review also points to a wave of new treatments that could transform care for patients affected by the interconnected conditions.

Drugs originally developed for obesity and type 2 diabetes are now showing benefits across the liver, heart and kidneys simultaneously.

Semaglutide, best known as a weight-loss treatment, has become the first medicine to demonstrate benefits, while newer drugs including tirzepatide and retatrutide are producing promising results in clinical trials.

The researchers say routine liver screening should become part of kidney and cardiovascular assessments, particularly in patients with obesity, diabetes or other metabolic risk factors.

They also call for major clinical trials and healthcare services to move beyond treating diseases organ by organ and instead adopt integrated approaches reflecting how these conditions interact in the real world.

Dr Will Marshall clinical research fellow at The University of Manchester and senior author of the study, said: "For many years we have viewed heart disease, kidney disease and liver disease as separate conditions managed by different specialists.

“The evidence now shows that these organs are deeply interconnected through shared biological pathways driven by obesity, insulin resistance and chronic inflammation.”

Dr Marshall, who is also based at Salford Royal added: “Fatty liver disease is not simply a consequence of metabolic ill health, it is an active contributor to it.

“Recognising the liver as a core component of cardiometabolic disease could help clinicians identify high-risk patients earlier, improve treatment decisions and ultimately prevent thousands of serious complications and premature deaths."

· This paper is a peer reviewed narrative review which cites 55 references in its bibliography, covering epidemiological studies, clinical trials, meta-analyses, guidelines, reviews, and expert commentaries.

• The study Integrating the liver into the cardiovascular-kidney-metabolic syndrome: pathophysiology and therapeutic implications is published in journal DOI 10.1097/MNH.0000000000001225

A “peculiar” new species of Jurassic squid-like animal has been unearthed in Wyoming, USA, following the discovery of two exceptionally rare fossils dating back around 160 million years.

The newly named species, Wyoteuthis linsterorum, has been identified as a type of ancient cephalopod, called a belemnite, cousins of modern squid and octopus. They say unusually thick, barrel-shaped skeleton makes it the "chunkiest” or “fattest" belemnite ever discovered.

An international team of researchers from the USA, UK and New Zealand, including Dr Dean Lomax, Honorary Research Fellow at The University of Manchester, describe the discovery in the journal today.

Belemnites are among the most common fossils found worldwide and are recognised by their bullet-shaped remains, known as a rostrum or guard. Millions have been discovered in Wyoming's Sundance Formation, an ancient inland sea that once covered the western USA.

Co-author and Wyoming palaeontologist, Jessica Lippincott, said in Wyoming, they are nicknamed “squid butts”.

The chunkiest belemnite ever discovered

Most Wyoming belemnites are bullet-shaped measuring around 5 to 10 centimetres long and only 1 to 2 centimetres wide. By contrast, the newly discovered species had an unusually broad, barrel-shaped rostrum around 10 centimetres long but up to six centimetres wide, making it the thickest belemnite ever recorded.

Researchers estimate the living animal would have reached around 60 centimetres in total length including its arms.

The work was instigated by Wyoming palaeontologist and co-author Bill Wahl, who has spent much of his career searching for fossils in Wyoming and said this belemnite “stuck out like a sore thumb”. He brought together an international team of researchers to investigate the remarkable specimens, including belemnite expert Alexey Ippolitov, now at Victoria University of Wellington, New Zealand.

Using computed tomography (CT) scanning, the team were able to examine the fossils without damaging them, revealing internal features that confirmed the animal belonged to an ancient family of belemnites previously thought to have disappeared millions of years earlier.

PhD student, Ippolitov said he was "deeply surprised" to discover a fossil from such a well-studied group that differed so radically from anything previously known. After more than 200 years of palaeontological research on belemnites, he said, discoveries like this are exceptionally rare.

Ippolitov explains: “A possible explanation is that their relatively large size gave them an advantage when hunting co-occurring smaller belemnites of the genus Pachyteuthis. Modern squid, after all, are hardly picky when it comes to prey: they readily hunt not only other species of cephalopods, but sometimes even their own kind.”

30 years in the making

The discovery was almost 30 years in the making. The first specimen was unearthed in the late 1990s by Dr Burkhard Pohl, founder of the Wyoming Dinosaur Center, after he spotted a belemnite much bigger than any he had seen before. The fossil sat unstudied in the museum's collection draw for many years until a second specimen was discovered by fossil collector Cliff Linster near Ten Sleep, Wyoming, and donated to the Wyoming Dinosaur Center in 2019. Together, the two fossils provided the evidence needed to identify and formally describe the new species.

Honouring a fossil collector's legacy

The name Wyoteuthis translates to “a squid from Wyoming”, while the species name, linsterorum, honours Cliff Linster and his family. Cliff discovered one of only two known specimens of the new species and donated it for scientific study.

Co-author and Wyoming palaeontologist, Jessica Lippincott, said: “After spending years fossil hunting in Wyoming and collecting countless fossils of the common Pachyteuthis belemnites here in Wyoming, this one is unlike anything I have ever seen! It goes to show that we are still finding new species of fossils all the time, and people who rockhound or collect invertebrate fossils can also contribute to science.”

Cliff Linster passed away in June this year. He knew researchers were studying his remarkable discovery and was excited to see it formally described. The Linster family are no strangers to finding amazing fossils, perhaps most famously the dinosaur Bambiraptor.

Co-author and British palaeontologist, Dr Dean Lomax, an Honorary Research Fellow at The University of Manchester and an 1851 Research Fellow at the University of Bristol, in the UK, dug up dinosaurs with Cliff and his wife, Sandy, when he was a teenager. He said: “I met Cliff and Sandy in 2009, when I spent a week digging up a dinosaur bonebed on their property in northern Montana. I have fond memories of that dig, listening to Cliff share his passion for fossils, including this belemnite. I’m honoured to help name this fossil after Cliff. It’s bittersweet that he didn’t get to see it published, but it’s wonderful that we can immortalise him and his family name in the history of palaeontology. The find is incredibly rare, which might be due to some ecological adaptations to the environment at the time. Perhaps its rarity is a result of narrow specialization.”

Dr Lomax is also the author of the recently published book, “The Secret Lives of Dinosaurs”, which highlights Wyoming fossils, and he has spent time collecting fossils and excavating plesiosaurs and ichthyosaurs in Wyoming’s Sundance Formation.

Both specimens are on display at the Wyoming Dinosaur Center in Thermopolis, Wyoming USA.

Publication details

The new study has been published in the international journal, Papers in Palaeontology.

DOI:

The exact timeline of the recent Nepal flooding disaster is becoming clearer. At 8:37am, instruments recorded what was initially interpreted as an earthquake near ����貹��’s border with China. Seven minutes later, CCTV recorded the Gyirong Port border post being destroyed by a massive debris flow and flood.

flood authorities learned about the incident at about 9:00am and sent out an emergency SMS alert at about 9:15am. But by that time, Nepal was already deep into a major disaster.

The 38 minute gap between the tremor being detected and the emergency alert is striking. But it would be wrong to assume ����貹��’s authorities could simply have acted on the initial signal: at the time, it appeared to be a small earthquake, rather than a much rarer mountain collapse. The flood also arrived too swiftly for water-level sensors: they went almost immediately from recording normal levels to being destroyed.

The more interesting question is what a better-integrated warning system might have made possible. Could seismic readings, satellite images and other observations have been combined quickly enough to recognise what was happening and alert people further downstream?

Existing early-warning systems have often been designed around particular hazards such as regular rain-caused floods or . But this disaster was neither a Glof nor a regular flood. Instead it appears to have involved a rare, large-scale collapse of rock and ice, which turned into a devastating debris flow and flood.

As a of a strikingly similar flood in India last year argued, this type of hazard is largely absent from existing warning frameworks. As , such events are likely to happen more often.

Cascading mountain hazards that cross borders

In July 2025, a glacial lake in Tibet burst and swept down into Nepal, killing at least nine people and leaving around 20 missing in Nepal. Eleven people were also officially reported missing on the Chinese side.

After the flood, Nepal and China agreed in principle to share real-time information about floods, landslides and glacial lakes. However, despite ����貹��’s foreign minister during a visit to China in May 2026, no formal agreement has been signed.

Across the Himalayas and Hindu Kush mountain ranges, rivers, weather systems and infrastructure frequently span national boundaries. Our shows a hazard that begins in one place can have lethal consequences – and create new warning requirements – far downstream.

A warming climate is by thinning glaciers, thawing permafrost and destabilising slopes, even if climate change isn’t the sole explanation for every disaster. Meanwhile roads and hydropower projects are putting more people and infrastructure in threatened valleys.

Cooperation has to come before the disaster

Some cross-border early-warning arrangements already exist between Nepal and its neighbours, particularly for recurring floods. But sudden, cascading events such as the recent disaster pose a different challenge. A warning has value only if it travels the whole distance – from a sensor in the mountains, through scientific agencies, national and local authorities, to households in the valleys and plains below, in the minutes that matter.

Community-based flood warning already works in parts of ����貹��’s Koshi basin, where upstream gauges and trained local volunteers buy downstream villages precious time. A regional early warning system would have to link these community-level systems with national and cross-border monitoring, so that information can move from the source of a hazard to the people at risk. That means agreeing in advance what should be shared, how warnings should be passed between countries and agencies, and what action they should trigger.

That requires institutional changes and political commitment, as much as new technology. The region’s existing water treaties were written to divide flows and manage dams and barrages, not to govern cascading hazards in the high mountains. Governments could establish permanent bodies responsible for Himalayan rivers and their associated hazards. Featuring both scientists and policymakers, and linked to counterparts in neighbouring countries, these public bodies would be mandated to share data, jointly monitor glaciers, lakes and slopes, and coordinate warnings across borders.

The aim would be to make cooperation routine and sustained between disasters, rather than improvised in a crisis when events may unfold too quickly for international debate. None of this requires neighbours to resolve their wider disputes; it asks only that disaster warning be ring-fenced as shared humanitarian infrastructure that keeps working unabated.

The technologies for predicting and monitoring high-mountain hazards are improving fast. We now need more international scientific and policy cooperation, and warning systems capable of turning these observations into rapid action.

By , Senior Research Fellow and Lecturer in Environmental Management, ; , Lecturer in Disasters and Global Health, Humanitarian and Conflict Response Institute, ; , Assistant Professor, Department of Geography, , and , Associate Professor, Department of Geomatics Engineering,

This article is republished from under a Creative Commons license. Read the .

University of Manchester scientists have uncovered a hidden role for immune cells in the womb, opening the door to new treatments for infertility, miscarriage and other reproductive conditions that affect millions of women worldwide.

The findings are a breakthrough in our understanding of women's reproductive biology, one of the most under-researched areas of medicine, despite infertility and pregnancy complications affecting millions of families.

The researchers hope their findings will accelerate efforts to develop targeted therapies for a range of conditions in urgent need of advancement, including recurrent miscarriage, IVF implantation failure, uterine fibrosis (scarring) and non-cancerous growths in the womb called fibroids.

Using mouse models and samples from women, specialised white blood cells called monocytes, they found, play a vital role in keeping the uterus healthy throughout the menstrual cycle.

Their findings, published in Nature Immunology today, reveal that these cells manage inflammation, repair tissue and maintain the womb lining, challenging long-held assumptions about how the uterus regulates itself.

They showed that during a healthy menstrual cycle, large numbers of monocytes move from the bloodstream into the uterus at specific times each month.

Once there, they are able to promote inflammation when needed or help repair and rebuild tissue.

Monocytes, they add, are essential for normal tissue turnover in the womb, though when missing, the uterus developed abnormal tissue structures and scarring causing problems with reproduction, with the mice having fewer pups per litter.

Using mouse models to track how immune cells in the womb develop over time, they determined that once recruited to the womb, monocytes turn into two different types of specialised immune cells (macrophages), one causing inflammation and one promoting tissue repair .

The findings were particularly striking in women with Asherman Syndrome, an often undetected condition in which scar tissue forms inside the uterus and can cause infertility, recurrent miscarriage and pregnancy complications.

The team discovered unusually high numbers of inflammatory monocytes in women affected by Asherman’s syndrome. Rather than rising and falling naturally throughout the menstrual cycle, the cells remained persistently elevated and clustered around specialised glands in the lining of the womb.

The study suggests this abnormal immune activity in mice may contribute to the development of fibrosis and scarring inside the uterus.

The work could help identify new treatment strategies, such as blocking inflammatory pathways or targeting molecules that control the movement and behaviour of monocytes, which aim to restore a healthy immune balance in the womb.

Dr , senior author of the study from The University of Manchester, said: "For many years we have known surprisingly little about the immune cells that live and work within the uterus.

“Our study shows that one type of immune cell - monocytes - are not simply bystanders but essential for maintaining a healthy womb.

“When their behaviour becomes disrupted, normal tissue repair processes can go wrong and scarring may develop.

She added: “We hope these findings will pave the way for new treatments that improve fertility and reproductive health for women affected by inflammatory womb conditions."

“The lack of knowledge in this area reflects the historic underfunding and low prioritisation of women’s health.

“One critical consequence of this is the dramatic decline in global fertility rates, set to transform global population patterns.”

• The DOI for the paper is 10.1038/s41590-026-02651-y and is available

The pupils most at risk

• Pupils receiving SEN support were more than twice as likely to be suspended as pupils without SEN, while those with an EHCP also had more than twice the odds of suspension.
• Pupils eligible for free school meals were nearly two and a half times more likely to be suspended than those who were not eligible.
• Pupils reporting higher levels of peer pressure and experiences of bullying victimisation were more likely to be suspended.
• Pupils who reported they had used any substance in the past 30 days were nearly three times more likely to be suspended than those reporting no recent substance use, in part because substance use is itself direct grounds for suspension under DfE guidance.

What could help prevent suspensions?

• School belonging, satisfaction with academic attainment and positive relationships with school staff were all associated with lower odds of suspension.
• Stronger emotion regulation was also associated with lower suspension risk.
• Suspensions are associated with multiple overlapping individual and school-level factors, highlighting the need for preventative approaches that address underlying needs rather than relying solely on disciplinary measures.

The research used data from the #BeeWell programme, a youth wellbeing measurement programme led by The University of Manchester in collaboration with Anna Freud, a children’s mental health charity, and the Gregson Family Foundation.

The #BeeWell survey captures young people's wellbeing alongside factors that can influence it, including school experiences, health behaviours, peer and family relationships and neighbourhood characteristics. Survey responses can be linked with administrative data held by participating local authorities, allowing researchers to examine young people's experiences alongside information about suspension and exclusion.

The researchers analysed data from 19,064 pupils in Years 8 and 10 across 69 mainstream secondary schools in Hampshire and Southampton during the 2023/24 academic year. Around six per cent of pupils in the study had been suspended at least once during the academic year.

Looking beyond suspension and moving towards engagement

“Our findings show that suspension is not simply about what happens in an individual classroom or about a young person's behaviour in isolation,” said lead author Dr Stephanie Cahill. “Pupils' experiences of disadvantage, their relationships with peers and staff, their sense of belonging and their additional educational needs all form part of a much more complex picture.

The researchers say the findings highlight the importance of early intervention and preventative support, particularly for pupils experiencing disadvantage or additional educational needs.

Supportive relationships between pupils and school staff, as well as a strong sense of belonging, may play an important role in helping young people remain engaged with education.

The study also highlights the importance of understanding the different pathways that can lead to suspension– a one-size-fits-all approach is unlikely to work for all pupils.

The researchers caution that the study identifies associations rather than causal relationships. Further research is needed to understand the mechanisms underlying these patterns and how schools can most effectively intervene to prevent suspensions.

“We recognise that the current climate within education has meant that many teachers are working under very challenging conditions and that often ‘blanket’ approaches are taken due to limited capacity,” said Professor Neil Humphrey. “In order to ensure more work can be done to understand individual pathways and prevent suspensions, there needs to be increased support for schools from the government.”

You can find helpful resources from #BeeWell on school belonging

Publication details

The study was published in the British Educational Research Journal.

DOI:

A by University of Manchester scientists says sophisticated lab-grown tumours could help fast-track the search for new cancer treatments while reducing reliance on animal testing.

Publishing in the British Journal of Cancer, the researchers assessed biomaterial-based cancer models using advanced materials known as hydrogels.

The models recreate key features of tumours in the lab, offering a potentially quicker way to study how cancers grow and spread.

The technology could also help scientists identify promising drugs more quickly by providing a realistic testing environment before treatments reach clinical trials.

However, the researchers stress that animal studies will remain an important part of cancer research for the foreseeable future, often providing valuable evidence about disease and drug safety.

And unlike animal research, the new technology cannot yet replicate the whole-body complexity needed to assess all aspects of drug efficacy and safety.

Hydrogels, which are derived from synthetic, plant, human or animal cells, act like a scaffold and closely mimic the environment surrounding cancer cells inside the human body.

The technology allows scientists to add cancer cells and other cell types to three-dimensional structures, creating miniature tumour ecosystems that reflect what happens in patients better than conventional two-dimensional models.

The three-dimensional tumour models are designed to mimic real cancers more closely, recreating key features such as cell interactions and drug resistance.

Two-dimensional cell cultures often fail to replicate the complexity of tumours, leading to promising drugs appearing effective in the laboratory only to disappoint in later testing.

Eve Tipple, a PhD researcher from The University of Manchester and lead author of the review, said: “Though animal research will remain for the foreseeable future, continued advances in biomaterials could pave the way for a new generation of cancer models that are relevant to human disease.

“This technology might help researchers make better decisions earlier in the drug development process and accelerate the arrival of life-saving treatments for cancer patients worldwide.

“The technology could cut the number of animals used in research, save millions of pounds, and speed up the search for life-saving treatments.”

Cancer remains one of the world's biggest killers despite huge advances in treatment, and one major reason is that most new drugs never make it to patients.

For decades, researchers have relied on simple 2D cell cultures grown on flat plastic surfaces.

But these models fail to capture the complexity of real tumours, which contain intricate networks of cells, tissues and chemical signals.

As a result, drugs can appear highly effective in the lab only to disappoint in later testing.

She added: “Cancer is far more than a collection of diseased cells because the environment surrounding a tumour strongly influences how it grows, spreads and responds to treatment.

“Biomaterial-based models allow us to recreate many of these complex conditions in the laboratory with a level of control that was previously impossible.

“This gives researchers a powerful platform to study cancer biology, improve drug testing and ultimately help bring effective treatments closer to patients.”

• The paper Using biomaterial-based 3D in vitro cancer models to solve current clinical problems DOI .
• Image shows a 3D model

There is no credible scenario in which expansion at Heathrow can go ahead without blowing a hole in the UK’s legally binding climate targets, new modelling published by the Tyndall Centre for Climate Change Research at The University of Manchester reveals today.

The report, commissioned by the environmental justice organisation Friends of the Earth, provides the first detailed analysis of whether Heathrow expansion is compatible with the UK’s legal carbon budgets.

Recent approvals of airport expansion at Gatwick, Stansted Luton and many other locations mean that UK aviation is already projected to exceed its share of the Seventh Carbon Budget (2038-42) by between 21 and 50%, depending on how much sustainable aviation fuel materialises. That is before any Heathrow expansion takes place.

The analysis concludes that the two technologies relied upon to enable passenger growth or airport expansion to fit within carbon budgets – Sustainable Aviation Fuels (SAF) and Greenhouse Gas Removals (GGR) – are not even close to being on track for sufficiently capacity within the required timeframe.

The report concludes that Heathrow expansion cannot credibly meet the UK’s climate targets thanks to three key findings:

• Aviation emissions: The UK’s aviation sector will already exceed its share of the Seventh Carbon Budget by around 40%, even before Heathrow expansion is considered. The research highlights how even the government’s own modelling reaches a similar conclusion.

• Sustainable Aviation Fuels (SAF): Based on existing evidence SAF would be unable to close the emissions gap. Even optimistic deployment of this technology would leave aviation above its carbon budget share. Previous studies have shown that current SAF production methods face major structural constraints or compete with agriculture for land and water, just as farmers have experienced what could be the worst harvest on record and are already warning about the impact of the climate crisis on food production.

• Greenhouse Gas Removals (GGRs): GGR describes methods that remove carbon dioxide from the atmosphere and stores it long-term, such as bioenergy with carbon capture and storage. The report highlights how global GGR deployment is significantly off track and that no engineered removal plants are operating yet in the UK. Despite this, aviation emissions modelling heavily relies upon future potential GGR to offset additional emissions. Even before any airport expansion is taken into account aviation is the biggest projected user of GGR capacity. On top of this, these scenarios all depend on SAF pulling its weight; if SAF fails to deliver, even more GGR will have to be deployed. The report concludes that the building capacity for more aviation demand before large scale GGR facilities are operational is inconsistent with taking climate targets seriously.

• Non-CO₂ impacts are not accounted for: Aviation's full warming effects are not captured within carbon budgets. Non-CO₂e impacts including from nitrogen oxides and contrails, account for around two-thirds of aviation's climate warming and should be incorporated into future climate targets.

What do the researchers say?

The lead researchers, , and recommend decisionmakers reject any proposed expansion at Heathrow Airport.

Dr Lois Pennington, Research Fellow at the Tyndall Centre said:

“Every aviation scenario the UK Government has published overshoots the carbon budget Parliament has legislated, before a third runway at Heathrow is even taken into account.

“Our analysis shows that aviation cannot continue to grow if the sector is to make a proportionate contribution to meeting the UK’s carbon budgets. Sustainable aviation fuels and carbon removals can contribute to limiting aviation emissions, but there is currently no evidence that these technologies can support the scale of aviation expansion envisaged by the government.

“Further aviation expansion carries a significant risk of exacerbating climate impacts by relying on the growth of technologies that are unlikely to materialise in the timescale needed.

“The UK is experiencing another exceptionally hot summer, while record-breaking severe wildfires have burnt across Western Europe. The Government must reassess the case for expansion. Climate policy must be grounded in what we can demonstrate and evidence, rather than what we hope may become possible.”

Mike Childs, head of policy, science and research at Friends of the Earth, said:��

"After this summer of record-breaking heat and nearly 3,000 excess deaths, this third runway is the equivalent of pouring petrol on a raging wildfire.

"The evidence is clear: there is no route where expansion at Heathrow can be in line with our legally binding climate targets. Suggesting that sustainable aviation fuel and greenhouse gas removals can enable airport expansion is simply trying to pull the wool over people’s eyes.

"The government has a choice: commit to taking action on the climate seriously, reject Heathrow expansion and constrain excessive flying, or abandon the UK's climate targets and future generations by giving the third runway the go ahead.

"With a weak economic case to support expansion set against a huge impact on the climate and communities, this is the opportunity for the new Prime Minister to truly set a precedent by turning his back to corporate lobbying and say no to a third runway at Heathrow."

The public consultation on the government's Heathrow Expansion National Policy Statement (HENPS) closed earlier this week on Tuesday 1 September, the same day that members of parliament returned from recess to scrutinise the proposal.

Friends of the Earth and the researchers are calling on the UK Government to reject Heathrow expansion and ensure future aviation policy remains consistent with legally binding carbon budgets under the Climate Change Act.

Read the full report here:

Professor Konstantinos Stathopoulos is a leading corporate governance scholar whose research examines how companies are governed and how corporate decision-making affects different stakeholders. His work has a particular focus on executive compensation and the ways in which poor governance practices can affect stakeholder wealth. More recently, his research has examined the interests and influence of stakeholders, including employees, in corporate decision-making and governance.��

He is Vice President of the International Corporate Governance Society, Chair of the Corporate Governance Special Interest Group of the British Accounting and Finance Association and an Otto Mønsted Visiting Professor at Copenhagen Business School. He was Editor-in-Chief of Corporate Governance: An International Review from 2019 to 2024.

Professor Andreja Zevnik is an interdisciplinary scholar whose research explores political resistance, protest, race, identity and marginalisation.

Her work draws on psychoanalysis, continental philosophy, and postcolonial theory to examine how political identities and forms of resistance are produced. Her recent research has focused particularly on the racialisation and political mobilisation of Roma communities in Europe, Black Lives Matter and other forms of anti-racist political mobilisation. Her research with colleagues has also helped to raise awareness of antigypsyism and strengthen political representation and advocacy among Roma communities in Slovenia.

“Our newest Fellows represent some of the most influential voices in social science today,” said Will Hutton, President of the Academy of Social Sciences. “Their work is expanding knowledge, challenging assumptions and generating insights that are informing and even redefining decision making across government, business, education and civil society.”

“I am delighted to welcome these leading experts to the Academy, and look forward to working with them to raise the profile and impact of the social sciences across the UK and beyond.”

Using South Africa's MeerKAT radio telescope, the international team measured radio emissions from neutral hydrogen dating back to a time when the Universe was several billion years younger than it is today.

The findings, published in , demonstrate the potential of a technique known as hydrogen intensity mapping, which allows astronomers to study vast regions of the cosmos more efficiently than ever before.

Key findings

• Researchers directly detected the hydrogen intensity mapping signal using MeerKATradio observations alone.
• The signal comes from hydrogen that existed when the Universe was several billion years younger than today
• The measurement traces cosmic structures across scales of millions of light years.
• The results validate hydrogen intensity mapping as a practical new tool for cosmology, enabling scientists to probe the large-scale structure of the distant Universe.
• The technique could help future telescopes map the Universe more efficiently than traditional galaxy surveys.

How hydrogen intensity mapping works

Neutral hydrogen naturally emits a faint radio signal known as the 21-centimetre line. As the Universe expands, this signal is stretched to longer wavelengths, allowing astronomers to observe hydrogen at different stages of cosmic history.

Rather than detecting individual galaxies one by one, hydrogen intensity mapping measures the combined radio emission from many unresolved galaxies. This makes it possible to study enormous volumes of the Universe and build a three-dimensional picture of its structure.

Until now, reliable detections of this signal at these distances have typically relied on combining radio observations with optical galaxy surveys. In this new study, however, the team has directly detected the hydrogen intensity mapping signal using MeerKAT radio observations alone.

The team analysed around 96 hours of observations from MeerKAT and detected the signal from two periods in cosmic history, corresponding to emissions that have travelled approximately four to five billion years before reaching Earth. The measurements trace hydrogen across scales of several million light years - comparable to the distance between the Milky Way and its neighbouring galaxy Andromeda.

What the researchers say

“This is a very exciting milestone,” said Dr Sourabh Paul, lead author of the study. “Hydrogen intensity mapping has long been seen as a promising way to map the Universe efficiently, but the signal is extremely faint and difficult to isolate from foreground emission, human-made radio-frequency interference, and instrumental effects. Detecting it directly with MeerKAT shows that this technique is becoming a practical tool for cosmology.”

“This was a challenging data analysis process, requiring a detailed understanding of the many sources of contamination that can affect such a faint measurement,” Professor Santos added. “It is particularly remarkable that the data used in this study were taken in 2018, when MeerKAT had only just started science operations. There is now a rich trove of MeerKAT data waiting to be explored with this method.”

The researchers say the work opens up new opportunities to measure neutral hydrogen over cosmological distances and study how galaxies form and evolve over cosmic time.

Dr Zhaoting Chen, co-author of the study, said: “Neutral hydrogen is one of the key ingredients for understanding how galaxies form and evolve.

“With intensity mapping, we do not need to detect every individual galaxy. Instead, we can measure the collective signal from hydrogen across large cosmic volumes, giving us a new way to study both galaxy evolution and the underlying matter distribution of the Universe.”

The detection also has important implications for future cosmological surveys. Hydrogen intensity mapping is expected to become a major science driver for the Square Kilometre Array Observatory, for which MeerKAT is a precursor telescope.

co-author of the study from Jodrell Bank Centre for Astrophysics at The University of Manchester, added: “MeerKAT continues to open new windows for cosmology. The fact that this signal can be extracted from observations that were not originally designed for hydrogen intensity mapping is very encouraging. It shows the enormous scientific value of MeerKAT data and points the way to future observations with SKAO.”

The researchers say future observations covering larger areas of the sky and using longer observing times will enable astronomers to map hydrogen in even greater detail, helping reveal how galaxies formed, how dark matter shapes the cosmic web, and how the Universe has evolved over billions of years.

Publication details

The study was published in The Astrophysical Journal Letters

DOI:

Key points

• In the age of AI, business communications start to look more alike.

• The researchers generated AI-augmented twins of more than 26,000 real-world crowdfunding campaign descriptions. Across the resulting AI-augmented versions, there was substantially less variation than across the original human-written narratives. Among other differences, the AI-rewritten pitches varied 43% less in how abstract their language was, and variation in length and writing quality fell by around 80%.

• As AI makes polished communications easier to produce, audiences likely develop more demanding expectations about the quality of these communications.

• Business owners may increasingly need to provide evidence for the claims they make about their businesses, as audiences become less willing to rely on plausible-sounding statements alone.

• Cultural competence and storytelling skills could even become more valuable, rather than less, as it becomes more challenging to craft effective business communications in the age of generative AI.

What the experts say

"Generative AI can support entrepreneurs in many aspects of storytelling, but it cannot substitute for the cultural understanding required to navigate an increasingly complex evaluative environment," said lead author Dr Karl Taeuscher from The University of Manchester’s Alliance 91ֱ�� Business School. "Business owners will still need to understand their audiences, recognise cultural expectations and know how to position their businesses in ways that are both credible and distinctive."

The researchers caution that the study presents a plausible scenario rather than a prediction, as both AI technology and social norms surrounding its use are changing rapidly. The analysis of AI-augmented crowdfunding descriptions is intended to illustrate the research’s central argument rather than to test it.

Publication details

The research was published in the journal Entrepreneurship Theory and Practice.

DOI: .

A common but often overlooked cause of high blood pressure may be hiding in plain sight – and data from a pioneering wearable device could hold the key to its earlier diagnosis, according to new research.

The study, published in the journal concerns a condition called primary aldosteronism – a hormone disorder which affects up to one in five people with high blood pressure and puts them at higher risk of developing heart disease, stroke, diabetes, and other major health problems.

Researchers from the University of Manchester and the University of Bristol in the UK, the University of Bergen in Norway, and partners in Stockholm and Athens found that patients with the disorder experienced bursts of hormone production during the day as well as in the night while asleep, when routine blood testing is rarely carried out.

Thanks to an ingenious portable device, developed at the University of Bristol, the hormone levels of patients were able to be monitored round-the-clock in their homes rather than a hospital or research unit. This means hidden irregularities could be uncovered, which may normally go undetected by current testing methods, leading to earlier detection of health conditions.

91ֱ�� co-lead author , Clinical Research Fellow in Automated Sampling Clinical Fellow at the University of Bristol, and Senior Clinical Fellow at Bristol Hospitals NHS Foundation Trust said: “Primary aldosteronism is an important cause of high blood pressure and the most common cause of secondary hypertension we see in our blood pressure clinic. It could be affecting millions of people in the UK. However, due to the way hormones change during the day and the current complexity of the diagnostic process, diagnosis is often delayed or never made at all.

“In our study, patients were monitored at home during normal activity, and this allowed us to see how hormones changed over time in realistic settings. This approach could potentially revolutionise how we diagnose hypertension and ultimately reduce cardiovascular disease – particularly heart disease and strokes – that could have been prevented.”

The proof-of-concept investigation continuously monitored hormone levels every 20 minutes in 60 patients from Bristol, Bergen, Stockholm, and Athens, over a 24-hour period. The patients all wore a lightweight device – which is the size of a mobile phone and attaches at the waist – allowing hormones to be measured from the skin, while they carried out normal daily activities, including sleeping at night.

Called U-RHYTHM, the technology was adopted and advanced by the spinout company Dynamic Therapeutics in 2023.

91ֱ�� senior author , UKRI Future Leader Fellow at the University of Manchester, said: “By continuously monitoring hormones over 24 hours, we were able to reveal a previously hidden pattern of nocturnal hormone bursts. This gives us a much clearer understanding of the disease and could ultimately help doctors detect it earlier and treat patients more effectively.

“A more detailed mathematical and computational analysis of daily hormonal profiles could eventually also help uncover earlier and more subtle forms of the disease, opening new opportunities to improve outcomes for patients living with high blood pressure.”

Computational analysis of data from the device allowed researchers to track changes in aldosterone, the hormone responsible for regulating salt and water balance in humans, along with two closely related hormones known as 18-hydroxycortisol and 18-oxocortisol.

��

Existing tests may be missing patients because the study results showed aldosterone levels do not stay high all the time. Furthermore, the researchers found that even among some of the most severe cases of the disease, there were periods when hormone levels dipped below the minimum thresholds used to diagnose the condition.

Rather than finding persistently raised hormone levels, the researchers discovered repeated night-time bursts of hormone secretion while the day-night rhythm remained intact.

These hormone spikes, produced by the adrenal glands, were particularly prominent in patients whose disease was caused by a problem in only one adrenal gland rather than both. The abnormal hormone patterns disappeared after surgical removal of the affected adrenal gland, providing further evidence that the bursts were directly linked to the disease.

91ֱ�� co-author , Professor of Medicine at the University of Bristol and inventor of the U-RHYTHM technology, added: “The findings suggest that clinicians may need to rethink how they look for the disorder which the Endocrine Society clinical practice guidelines now recommend should be considered for all people with hypertension, also known as high blood pressure.

“Future diagnosis could move away from single time point blood tests and towards tracking the body's hormone rhythms over time, particularly the overnight patterns that appear to hold crucial clues to disease. Further research is needed to define the best clinical pathways, using dynamic hormone measurement, to ensure early diagnosis of this common and potentially curable cause of high blood pressure.”

The research was funded by EU Horizon 2020, the Trond Mohn Foundation, the UKRI Biotechnology and Biological Sciences Research Council (BBSRC), Medical Research Council, University Hospitals Bristol and Weston NHS Foundation, the Swedish Medical Research Council and Knut and Alice Wallenberg Foundation.

The findings support the University of Bristol's research 'Grand Challenge' focus on Understanding and Preventing Cardiovascular Disease and builds on NIHR-funded initiatives aimed at earlier identification of people with hypertension and other cardiovascular risk factors.

• Tissue corticosteroid rhythms are dysregulated predominantly during sleep in primary aldosteronism’ in . DOI: https://www.science.org/doi/10.1126/scitranslmed.aeb7517

The $4.3 billion Nancy Grace Roman Space Telescope is NASA's next flagship astrophysics mission that will investigate the nature of dark matter and dark energy, study how galaxies have evolved over cosmic time, and discover more than 100,000 planets beyond our Solar System.

Using a powerful 2.4-metre mirror, Roman will conduct fast, detailed scans of the sky in infrared light. The telescope will combine Hubble-quality imaging but with a field of view that is more than 200 times larger. Scientists estimate that observations Roman can complete in a day would take the Hubble Space Telescope around four years to achieve.

The mission will also generate an unprecedented volume of data. Roman is expected to capture around 1.4 terabytes of observations every day, producing more than 500 terabytes of data each year. By comparison, the Hubble Space Telescope has collected around 400 terabytes during more than 35 years of operation.

Dr Eamonn Kerins, from Jodrell Bank Centre for Astrophysics at The University of Manchester was appointed by the European Space Agency to the Roman mission. He leads the Exoplanet Demographics Working Group for the Transits in the Roman Exoplanets Survey (TRExS), one of two science teams working with Roman data to find planets around other stars. TRExS will focus on planets orbiting closer to their host star.

Dr Kerins is also a member of the Roman Galactic Exoplanets Survey (RGES). RGES will use the gravitational lensing effect to find planets further out from their hosts. Roman is the first survey to combine two detection methods to gain a more complete picture of distant planetary systems. Dr Kerins was also part of the Roman Observations Time Allocation Committee (ROTAC), the NASA panel responsible for determining the mission's final survey design.

The mission is expected to discover more than 100,000 planets orbiting other stars, dramatically increasing the number of known exoplanets and helping astronomers build the most comprehensive picture yet of planetary systems across our galaxy. NASA Senior Project Scientist Julie McEnery, who helps to lead Roman's scientific programme, is also a Physics alumna of The University of Manchester.

Scientists believe about 25% of the Universe consists of dark matter and around 70% of dark energy, yet neither is fully understood. Roman will study tiny changes in the shapes of millions of galaxies to map the distribution of matter and dark matter and trace how galaxies evolved. The mission will also investigate how the Universe has expanded over time and why that expansion appears to be speeding up, with dark energy thought to be the driving force behind it.

Beyond its studies of exoplanets and the dark Universe, Roman will observe black holes, quasars and other rare cosmic events, providing astronomers with new insights into some of the most extreme objects in the Universe.

The mission follows the launch of the European Space Agency's Euclid space telescope in 2023, another major international astronomy mission involving researchers from The University of Manchester. Together, Euclid and Roman will provide complementary observations that will help scientists better understand the evolution and structure of the Universe.

Roman is expected to operate for at least five years, producing vast quantities of data that will be used by astronomers around the world to address some of the most important unanswered questions in astrophysics.

Roman is scheduled to launch on a SpaceX Falcon Heavy rocket from NASA’s Kennedy Space Center in Florida, USA on 30 August 2026 at 07:26 EDT /12:26 BST / 13:26 CEST. Watch the launch live via NASA’s channel. Follow for updates.

Key findings

• Presenteeism is no longer simply about going into work while sick - people can now work while unwell from home or elsewhere.
• Digital technology can make it harder to switch off, with employees potentially feeling pressure to remain available through email, messaging platforms and other workplace technology even outside normal working hours.
• Mental health needs to be recognised alongside physical illness when considering why people work while unwell, as existing research has focused heavily on physical sickness.
• Working while ill can take different forms - from completing a normal working day remotely to doing only urgent tasks or checking emails intermittently.
• Employers should consider whether workers have flexibility to reduce their hours or workload when ill, rather than treating working while sick as an inherently good or bad behaviour.

Presenteeism is no longer just about physical presence

The researchers propose redefining presenteeism as the “behaviour of attending work in the state of suboptimal health, with varied location choices and degree of engagement”.

This means that presenteeism should be understood not simply in terms of whether someone turns up to work, but also where they work, what health problem they are experiencing and how much effort they put into working.

The authors argue that existing approaches to measuring presenteeism are too narrow because they generally focus on how often people go to work despite being ill, or on the extent to which illness affects their productivity. Instead, they propose a three-dimensional framework based on health, location and engagement.

Eight ways of working while unwell��

The first dimension considers whether presenteeism is triggered by a physical or mental health problem. The second considers whether someone works on-site or remotely. The third considers whether they work a full schedule with normal levels of engagement or reduce their hours and effort. Together, these dimensions produce eight different forms of presenteeism.

For example, an employee with a physical illness might go into the workplace and work a full day, while another might stay at home and only deal with urgent requests. Someone experiencing anxiety or depression could similarly work either remotely or on-site, with either full or reduced engagement.

The researchers say this approach could help distinguish between situations where working while ill may be harmful and situations where employees are able to adapt their work in ways that allow them to protect their health while meeting essential responsibilities.

The paper also highlights concerns about inequality in access to flexible working. Remote working is not available to everyone, meaning that some workers may be able to adapt their working arrangements when ill while others have little choice but to attend their workplace.

What the experts say

“The world of work has changed dramatically, but our understanding of what it means to work while sick has not necessarily kept pace with this transformation,” said Professor Cary Cooper, 50th Anniversary Professor of Organisational Psychology and Health at The University of Manchester. “Technology has given people much greater flexibility over where and when they work, but that flexibility can become a trap if employees feel they have to be available all the time.”

Making flexibility work for employees

The authors argue that future research should examine whether giving employees greater control over their location, working hours and workload can make presenteeism a more adaptive behaviour. They also call for greater attention to mental health-related presenteeism, which they say has been relatively neglected by existing research.

The researchers stress that working while sick should not automatically be regarded as either positive or negative. Instead, they argue that understanding how someone works while unwell - and the circumstances surrounding that decision - is essential to understanding its effects on health and performance.

The paper concludes that organisations need to strike a balance between maintaining performance and protecting employee wellbeing as digital technology continues to reshape the workplace.

Publication details

The paper was published in journal Health Psychology Research.

DOI:

In recent weeks, a range of open letters have been published highlighting the importance of Jodrell Bank, e-MERLIN and the wider radio astronomy capabilities based at the Observatory. Support has come from leading figures in science, culture and public life, as well as from organisations representing the international radio astronomy community.

Lending their voices to support the positive impact, which the whole of the Jodrell Bank site has given to UK science and culture, signatories include Professor Brian Cox, Sir Brian May, Tim Peake, Chris Hadfield, Professor Jim Al-Khalili, Simon Armitage, Johnny Marr, members of New Order and Elbow, Jarvis Cocker and Christopher Eccleston. Many have longstanding links with Jodrell Bank through public engagement programmes, artistic collaborations and the Bluedot festival.

Alongside this, letters have been received from international research organisations, observatory directors, scientific advisory groups and astronomy institutes from across the UK and Europe. Together, they underline the value placed on Jodrell Bank's scientific capabilities, its role in training future generations of scientists and engineers, and its contribution to international research partnerships.

The letters follow the announcement that funding for e-MERLIN, the UK's national radio telescope network operated from Jodrell Bank Observatory, is due to end in March 2028 unless alternative support can be secured.

At the heart of Jodrell Bank's scientific work is e-MERLIN, the UK's national radio telescope network. By linking seven radio telescopes across England, it enables scientists to study the universe with a level of detail comparable to some of the world's most advanced astronomical instruments.

The University has made clear its commitment to securing the future of the Lovell telescope and radio astronomy at Jodrell Bank and is continuing discussions with partners on potential long-term funding solutions.

The growing body of support from across the scientific community and beyond, underlining the importance of Jodrell Bank to research, skills, education and inspiration for future generations.

Find the full list of letters here:

It is the culmination of over a decade of international collaboration by of The University of Manchester, Professor Juan Ruso of the University of Santiago de Compostela in Spain and Dr Natalia Hassan of the Metropolitan Technological University in Chile.

The discovery could have far reaching implications on the treatment of clotting disorders like haemophilia or the healthcare for patients on blood thinners like warfarin, as scabs forming on the surface of blood are vital to sealing a wound and keeping the site free of infection.

It could also explain aspects of how a lung can collapse in acute respiratory distress syndrome (ARDS), as fibrinogen disrupts the oily layer that keeps the airways open during breathing.

It may also transform the design of biosensors that allow people to monitor how their blood is performing, as the sensors rely on understanding how proteins disrupt those surfaces.

For more than twenty years the field has relied on a ‘single tilting layer’ model for fibrinogen where the long protein molecules lay flat on the surface at first and then leaned upright as more of them arrive.

But the new study, published in the on today (20/08/25), shows the benchmark model missed that fibrinogen stays lying flat and builds multiple layers that stack like sheets of paper. These layers grow thicker and more complete as more molecules arrive.

This new information helps to explain how the long protein molecules line up on the surface of blood where fibres called fibrin form the basis of the scab, a solid film formed during evaporation of fluid at the blood surface, that seals a wound.

The scientists used an advanced technique called neutron reflectometry at the part-UK-funded Institut Laue-Langevin (ILL) in France, where Dr Campbell was formerly based.

The team demonstrated that this behaviour holds true across multiple ranges of concentration and in very different solution conditions, showing the mechanism is not a rare quirk but a universal feature of fibrinogen when it contacts air.

Principal investigator Dr Campbell explained: "It's never easy challenging an established model of how molecules behave in nature.

“But through using the advanced technique neutron reflectometry on the FIGARO instrument at the ILL research facility, we could see the structure of these protein surfaces in more detail than scientists had seen before.

“Although lab data recorded in the past was compatible with the concept of a ‘single tilting layer’ model, our new data show multiple layering as a fundamentally different way of working.”

Dr Glenn Coope, a former PhD student at The University of Manchester but now based at Lund University in Sweden, said: "When the covid-19 pandemic struck, I spent time analysing structural data of how fibrinogen gathered at liquid surfaces while working from home.

“Then after returning to work at the University, I applied additional experimental methods.

“It’s almost like we now have a full circle moment, as our findings may help scientists to understand better the behaviour of fibrinogen in the lungs of patients suffering from ARDS, a condition that tragically claimed so many lives during the pandemic.”

Dr Campbell added: “Our discovery sheds new light on how scabs form on the surface of an open wound, where fibrinogen works in a protein‑rich zone to stop bleeding.

“Having better understanding of the structure of fibrinogen at liquid surfaces can only help in the search for new and better treatments for patients whose wound refuse to heal.”

• The paper Redefining Fibrinogen Self‑Assembly at the Air–Water Interface: An Intriguing Story with Multiple Layers is published in Journal of the American Chemical Society. DOI
• Other researchers from the University of Manchester and Institut Laue-Langevin contributed to the study

In a survey of 4,270 adults from across the UK, the researchers found that 79% had already used some form of self-monitoring, ranging from tracking blood pressure and blood sugar to monitoring fitness, diet, eyesight, hearing and mental wellbeing.

Published in the journal ��the findings suggest self-monitoring could play a major role in helping people spot health problems earlier and take greater control of their wellbeing.

The study was part-funded by a National Institute for Health and Care Research (NIHR) Senior Investigator award to lead researcher Professor Kevin Munro and was supported by the NIHR Biomedical Research Centre: 91ֱ��’s Hearing Health Theme.

The results chime with the Governments aspirations for health monitoring technologies to be part of routine care to support proactive health monitoring and preventative action.

The study also found that 86% of respondents would be willing to monitor at least one aspect of their health if recommended by the NHS.

Trust in the technology was high, with between 70% and 94% of participants saying they trusted the results produced by self-monitoring tools.

More than three-quarters (78%) said they would be happy for their results to be sent automatically to their GP.

The researchers say the findings highlight growing public support for a future in which patients can play a more active role in managing their health from home.

People who used self-monitoring said the main benefits included increased awareness of their health, a greater sense of control, easier access to information, more balanced conversations with healthcare professionals and improved psychological support.

However, the study also revealed that participants reported concerns including anxiety, obsessive testing, confusion about results, poor motivation to continue monitoring and worries about technology.

And between 14% and 38% of people said they would take no action if self-monitoring identified a potential problem, depending on the health issue being monitored.

Younger adults and people with higher levels of education were more likely to use self-monitoring, while men, older adults, those living in deprived areas and people with lower education levels were less willing to do so.

The researchers say these differences risk creating new health inequalities if self-monitoring becomes a larger part of healthcare in the future.

Lead researcher from The University of Manchester�� said: "Our findings show that self-monitoring of health is already a normal part of life for many people across the UK and that there is strong public enthusiasm for doing more of it in the future.

“Self-monitoring has huge potential to support earlier detection of problems, encourage preventative action and help people take greater control of their health.

Professor Munro, who is also an NIHR Senior Investigator added: “However, we must ensure that nobody is left behind and that these technologies are introduced in ways that are accessible, understandable and equitable for all sections of society.

“Nevertheless, self-monitoring could help transform healthcare through more proactive and preventative approaches though�� further research is needed to ensure it can be used effectively and fairly alongside traditional clinical care.”

• The paper Use, trustworthiness and willingness to self-monitor health and personal wellness: a UK population survey is available . DOI 10.1186/s13690-026-02035-6
• Image created with AI

The common statistical mistake, they warn in a new in PNAS on 10 08 26 – one of the world’s leading scientific journals - could be leading researchers to draw the wrong conclusions from their data.

A p-value, which measures how surprising the observed data would be if there were truly no effect, of greater than 0.05 does not, they say, show there is 'no effect'.

However, the interpretation remains widespread in about 50% of research papers and conference presentations, according to sources.

Instead, the authors say, a non-significant result simply means there is insufficient evidence to conclude a difference exists, not proof that a difference does not exist.

Crucially, the same statistical result can arise either because there is genuinely no meaningful effect or because an important effect is hidden by small sample sizes or highly variable data.

The researchers argue that failing to recognise this distinction risks oversimplifying scientific findings and may cause potentially important effects to be overlooked.

With many studies not having a large-enough sample size to detect the real difference, reporting that there is none can miss promising therapies or fail to detect genuine risk, derailing subsequent research in the area.

Equivalence testing, they say, guards against declaring an effect unimportant when the data cannot support that claim. A small or noisy study will usually return an inconclusive result rather than a verdict of no difference, which is the honest answer.

To address the problem, the team is promoting a statistical approach known as equivalence testing.

Rather than asking whether there is evidence for a difference, equivalence testing asks whether any difference that exists is too small to matter in scientific, clinical or practical terms.

The method allows researchers to distinguish between effects that are genuinely negligible and results that remain inconclusive because there is not enough reliable evidence.

They focus on the two one-sided tests procedure, or TOST, which has already gained traction in psychology, medicine and pharmaceutical regulation but remains underused across many areas of the life and natural sciences.

Wider adoption of equivalence testing, they add, could improve the quality of scientific reporting and help prevent non-significant findings from being misrepresented as evidence of no effect.

Co-author, Professor of Cardiac Physiology from The University of Manchester, said: “Researchers are often interested in whether an effect is absent or too small to be important, but traditional statistical testing cannot answer that question.

“A non-significant result is frequently interpreted as proof that nothing happened, when it may simply mean there is not enough evidence to be certain.”

Co-author Jakub Tomek from the University of Oxford said: “Equivalence testing helps separate genuinely trivial effects from unresolved questions, giving scientists a much clearer picture of what their data are actually telling them and improving confidence in the conclusions that are reported.

“We hope the method will encourage more careful interpretation of scientific data and improve the way research findings are reported, understood and acted upon.”

To make the approach more accessible, the team has also developed a free that allows researchers to perform common equivalence tests without writing computer code.

The calculator supports a range of widely used statistical comparisons and has been validated against established statistical software.

Co-author Aaron Caldwell from the University of Arkansas for Medical Sciences added: "Equivalence testing forces you to answer a question most studies never ask: how small is small enough to be uninteresting?

“”That is a scientific judgement, not a statistical one, and it has to be made before the data are collected. The payoff is that you can finally say something affirmative about an absence of effect rather than just failing to find one.”

• The paper Beyond “Non-Significant” Results: Why and How to Test for Practical Equivalence is available . DOI

The 2026 ARWU ranking places 91ֱ�� 51 in the world, 14 in Europe and sixth in the UK. It reflects the University's continued strength as a research-intensive institution rooted in 91ֱ�� and connected across the world.

The results also show improvements in two of the ranking's most prestigious indicators: Highly Cited Researchers and publications in Nature and Science. These measures point to the reach and influence of research carried out at 91ֱ��.

The ranking is published annually by ShanghaiRanking and is widely regarded as one of the world's most influential assessments of university research performance.

Professor Duncan Ivison, President and Vice-Chancellor of The University of Manchester, said: “These results are welcome recognition for 91ֱ��, however we must continue to improve in an increasingly competitive international higher education landscape.

“I am grateful for the hard work our colleagues contribute every day to advance knowledge, transform lives and deliver impact beyond the University.

"As we implement From 91ֱ�� for the world, our strategy to 2035, we will continue to focus on excellence and doing work that makes a difference to the communities we serve."

The University of Manchester’s 2035 strategy is a long-term commitment to transforming our teaching, research, social responsibility, and partnership for the public good.

The ARWU result adds to 91ֱ��'s strong performance across other major 2026 rankings, including 40 in the , 56 in the Times Higher Education World University Rankings 2026 and The University is also ranked fifth in the UK for employability in the 2026 Times Higher Education Global University Employability Ranking, and remains the most targeted university by the UK's top 100 graduate recruiters.

Professor Sarah Gaffen will join from the University of Pittsburgh where she currently holds the Gerald P. Rodnan endowed chair in the Division of Rheumatology and Clinical Immunology and is director of Basic Rheumatology Research.

Prof. Tracy Hussell, outgoing Lydia Becker Institute Director said: “Every institute benefits from a fresh perspective and I’m thrilled with the appointment of Professor Sarah Gaffen as the next director of the Lydia Becker Institute. She shares the same energy and enthusiasm I have for thinking beyond traditional research silos and boundaries. We also share the desire to promote and nurture people at all stages of their career”.

Prof. Gaffen’s work focuses on T cell cytokines, especially the interleukin-17 (IL-17) superfamily, where her team has shown how molecular signalling mechanisms protect the body against fungal infections (like Candida albicans) or dysregulate immunity to drive autoimmune diseases including psoriasis and rheumatoid arthritis.

Prof. Gaffen earned her BSc from and her PhD from , followed by postdoctoral training at , where her seminal research investigated the molecular aspects of interleukin-2 (IL-2) signalling pathways in lymphocytes.

After launching her independent academic career at the State University of New York at Buffalo, she transitioned to studying the enigmatic IL-17 superfamily of cytokine receptors, becoming one of the first in the field to evaluate its signalling pathways and its role in mucosal infections, in particular oral fungal infections caused by Candida albicans.

She also served as Vice President and President of the International Cytokine & Interferon Society and is a Fellow of the AAAS, American Academy of Microbiology and the American Association of Immunologists.

She said: “I am delighted to take on the role of Director of the Lydia Becker Institute at such an exciting time for immunology at The University of Manchester. The critical role of the immune system in virtually all disease conditions not to mention healthy ageing, next-generation drugs and vaccines, is clear. The ecosystem in 91ֱ�� - with its diverse expertise across immunology as well as ties to the NHS trusts - provides opportunities to bridge immunology across disciplines.

“I’m eager to work with partner centres and institutes, including and the in fields such as cancer immunology, neuroimmunology, and women’s health.�� I am personally passionate about mentoring and inspiring the next generation of scientists, especially fostering a diverse and inclusive training environment to bring out everyone’s best scientific potential.

“Relocating from the US to lead the institute is an exciting, admittedly daunting, new chapter in my career.�� I am already facing 91ֱ��’s ultimate test: choosing my football team!”

Prof. Gaffen will take over leadership of the Becker from our current director Prof. Tracy Hussell on January 1^st 2027. Tracy spearheaded the establishment of the institute and will step down after eight years in the role.

Prof. Hussell will now look forward to dedicating more of her time to developing the next generation of scientific talent. Having recently received the Nature Lifetime Achievement Award for Mentoring in Science for her career-long commitment to guiding emerging researchers, she is eager to lean further into this passion.

She said: "I will now focus on my mentorship role and providing assistance to Sarah whenever she needs it. Watch this space, there are exciting times ahead!"

“If I had to pick a few highlight from my eight years as Becker Director, they would be the diversification of Manchester’s immunology portfolio through our excellent body of early career fellows, our strength of interaction with 91ֱ��’s NIHR Biomedical Research Centre, our interdisciplinary interactions through our Wellcome Trust 4-year Immunomatrix in Complex Disease PhD programme and finally our new MRC Centre of Research Excellence in Exposome Immunology led by Judi Allen and Fiona Powrie.

Prof. Gaffen joins the Lydia Becker Institute at a particularly important time for 91ֱ�� immunology as we are just establishing our MRC Centre of Research Excellence in Exposome Immunology and currently uniting many of our core immunology teams within the University's AV Hill Building to form a Becker Immunology Hub.

Professor Duncan Ivison, President and Vice-Chancellor of The University of Manchester said: “I am delighted that Sarah will be joining The University of Manchester. She is an outstanding choice to lead the Lydia Becker Institute, bringing internationally recognised expertise in clinically-relevant cytokine biology and a strong commitment to mentoring and developing researchers. Sarah’s vision and leadership will build on the Institute’s existing strengths, helping to drive innovation, deliver real-world impact, and further enhance our world-leading immunology research.”

Key findings and recommendations

• China’s state support for green industries is effectively subsidising the global transition to a low-carbon economy.

• China has become dominant in the so-called ‘new three’ green technologies - batteries, electric vehicles and solar power.

• Attempts by countries such as the US and EU states to compete with China could slow the adoption of green technologies and increase the cost of decarbonisation.

• Governments increasingly face four broad choices - compete with China, cooperate with it, accept Chinese dominance, or abandon parts of the green transition.

• The UK should strengthen cooperation with China on green technologies rather than trying to compete directly.

• The UK should continue to avoid tariffs on Chinese green technologies and seek Chinese investment in UK manufacturing.

A global climate dilemma

The report says China now occupies a leading position across many of the technologies needed for the green transition including solar, wind, batteries, hydrogen and electric vehicles. Its dominance has helped drive down the cost of these technologies, but this has also created growing geopolitical and economic tensions.

“China’s dominance of green technology presents a fundamental dilemma for governments,” lead author Dr James Jackson of The University of Manchester’s Sustainable Consumption Institute. “The world needs these technologies to decarbonise, but efforts to compete with China risk making the transition more expensive and more difficult.”

The authors argue that countries should focus more heavily on cooperation - particularly where access to affordable green technologies is essential to meeting climate targets.

Opportunities for the UK

The report identifies green technology as an opportunity to improve UK-China relations following a period of strained diplomatic ties. It recommends that the UK should seek closer trading relationships with China, while maintaining the ability to challenge Beijing on other issues such as human rights.

Among its recommendations, the report says the UK should encourage Chinese EV manufacturers to establish production facilities in Britain, while using the country’s expertise in financial services to support investment in green technologies. It also recommends that the Bank of England consider measures used by China’s central bank to support the development of green industries.

Publication details

is published by The University of Manchester. Dr Jackson is the lead author, alongside Mathias Larsen of the Grantham Research Institute on Climate Change and the Environment at the London School of Economics.

The kidneys have a vital role in continuously clearing toxins from the body. AKI is a common clinical syndrome in which the kidneys stop working properly. It affects up to 1 in 5 people in hospital, usually as a complication of a severe illness or major surgery. 1 in 3 people with AKI experience it recurrently. Researchers highlight multiple missed opportunities in optimising continuing care after hospital discharge.

Funded by the National Institute for Health and Care Research (NIHR) and supported by the NIHR Patient Safety Research Collaboration (PSRC): Greater 91ֱ�� this is the first major investigation of post-discharge care for people with AKI to cover widespread care in general practices (GPs) across England. The study was published in today (12 August).

Researchers analysed the healthcare of more than 209,000 patients in England who had been discharged from hospital after an episode of acute kidney injury (AKI), using records from over 1,400 general practices (GPs). They found that the recommended clinical guidelines for continued follow-up care were often not followed, suggesting that AKI is not receiving sufficient attention at handover from hospitals to primary care.

Why follow-up care after AKI matters

Even after hospital discharge, people who have had AKI remain at a high risk of poor outcomes, including emergency hospital readmission, recurrent AKI and other acute severe illnesses, the development of lasting chronic kidney disease, and major adverse cardiovascular events.

Current recommendations are that when a patient who has experienced AKI is discharged from hospital back into the community, primary care should have a central role in supporting recovery, ensuring safe follow-up, and minimising the risk of worsening health. However, the study identified multiple gaps in post-AKI care as patients transition across care settings.

In the study, only 19% of hospital AKI episodes were documented in primary care records within 30 days of discharge using the recommended codes for AKI. The proportion was even smaller among people aged under 60 years and those who had major surgery.

The study evaluated not just documentation, but also clincal action. Despite regular contact with primary care healthcare professionals, many people did not receive simple recommended blood and urine tests to assess kidney health. Younger individuals and those without already known and documented health concerns were least likely to receive tests. Yet, these are often people who stand most to gain, because early action can help prevent avoidable health problems being stored up into the future.

The study concluded that improvements in the sharing of discharge information and follow-up after AKI could help identify people at risk sooner and improve outcomes for those transitioning from hospital to community care.

, GP and Professor of Primary Care at The University of Manchester and NIHR Greater 91ֱ�� PSRC, said: “Despite a decade of improvement initiatives in the UK, little was known about how closely primary care follows clinical guidelines after an episode of acute kidney injury.

Our study highlights the urgent need to implement kidney health strategies more effectively across both primary and secondary care. Improving post-AKI care requires greater adoption of a ‘kidney mindset’ and better integration of kidney health into existing services, helping to improve outcomes for patients transitioning from hospital to community care.”

Prof director of the NIHR Greater 91ֱ�� PSRC, said: “Patient safety depends on delivering the right care at the right time, particularly during transitions between healthcare settings. This study highlights significant opportunities to strengthen the follow-up care offered to patients after AKI, providing valuable evidence to inform future improvements in care for this population.”

Key recommendations for strengthening post-discharge care for AKI patients:

• Improve communication and sharing of information at discharge, to ensure that arrangements for follow-up care after AKI do not become lost during transition across care settings.
• Strengthen the implementation of kidney health strategies across primary and secondary care, including clear discharge arrangements and case-specific guidance on discharge summaries.
• Better resource these implementation strategies to strengthen follow-up care across multiple areas, such as early and ongoing patient engagement; coordination across care interfaces; and protocols to ensure clear delegation of responsibilities.
• Improve the identification and monitoring of kidney disease after AKI, including routine recording of AKI diagnoses and recommended blood and urine tests.

Podcast recommendation – Lost in Transition: How Care Gaps Impact Patient Safety

Transitions in care are high-risk moments for patient safety, whether from hospital to home, mental health settings to the community, or between healthcare services. An episode of the Voices for Safety podcast explored research insights into how to make transitions across care settings safer for patients. Prof Tom Blakeman, co-author of this post-discharge AKI study, is one of the guests in this special episode, sharing insights into AKI follow-up care.

The paper Examining variations in adherence to guideline-recommended post-acute kidney injury care in primary care in England: A population-based cohort study, published in BMC Medicine, is available at

Publication details

The study was published in the Journal of Sex Research.

DOI: .

Key findings

• AI adoption is heavily concentrated in London, the South East and larger businesses, meaning its economic benefits could reinforce existing regional and productivity inequalities

• The country lacks the computing and energy infrastructure needed to deliver the Government’s ambitions, which could consume more than a quarter of the UK’s electricity

• Poor-quality, fragmented data and outdated IT systems could hamper AI adoption across government

• Skills shortages are holding back AI adoption, particularly among smaller businesses and in the public sector, despite years of government investment in digital skills

• AI is not a ‘magic bullet’ for Britain’s economic and public-service problems, and rapid expansion could create new environmental, social and governance risks

Unequal benefits and risks

Researchers Nathan Critch and Darcy Luke say years of short-term and fragmented policymaking by successive governments have left the UK with significant infrastructure and capacity gaps which could undermine Labour’s plans.

The Government’s AI Opportunities Action Plan includes plans to increase UK AI computing capacity twentyfold by 2030, develop AI Growth Zones, establish a National Data Library and expand the use of AI across government and the wider economy.

The researchers warn that the benefits of AI are unlikely to be shared evenly across the UK without policies specifically designed to encourage wider adoption.

Only 15% of UK businesses had adopted at least one AI technology in 2022, with adoption particularly concentrated among larger companies. AI adoption was highest in IT and telecommunications and legal services, while it was much lower in hospitality, health and retail - sectors which employ large numbers of people.

AI firms and businesses using AI are also heavily concentrated in London and the South East.

The study argues that this creates a risk that AI will make already productive businesses and regions even more productive, while areas and sectors which have struggled with low productivity are left further behind.

UK lacks infrastructure for AI boom

The UK currently has only around 3% of the world’s computational power - much of which is not optimised for AI - leaving the country dependent on cloud computing provided by large technology companies.

The researchers warn that expanding computing capacity will place enormous demands on the UK’s energy infrastructure. They estimate that a twentyfold increase in UK computing capacity could increase the energy consumed by AI infrastructure from around 3.6 terawatt-hours (TWh) in 2020 to 72 TWh – more than a quarter of the UK’s total electricity consumption.

This creates a tension between the Government’s AI ambitions and its commitment to reaching net zero, particularly given constraints in the electricity grid and limited energy storage capacity. The researchers also highlight the water required to cool data centres as a potential environmental constraint.

Poor data and outdated technology

The study identifies the quality and accessibility of government data as another major obstacle. A National Audit Office survey found that 62% of responding government bodies identified a lack of access to good-quality data as a major barrier to implementing AI. Government data is often held in fragmented systems and legacy IT infrastructure, while data held by local authorities can be siloed across incompatible systems.

The researchers argue that these problems will make it difficult to deliver the Government’s plans for AI-enabled public services without significant investment in underlying digital infrastructure. They also warn that the public sector faces persistent digital skills shortages, with problems particularly acute in local government.

Skills shortages could limit AI adoption

Despite a relatively strong range of AI-related training in the UK, demand for AI skills continues to outstrip supply.

Smaller businesses are particularly disadvantaged because larger companies can offer higher salaries and attract workers with scarce AI expertise. The researchers also highlight a lack of in-work training, vocational education and further education provision compared with the emphasis placed on higher education.

These problems could limit the Government’s ambitions to use AI to improve productivity across the economy and make public services more efficient.

Decade of AI policy leaves UK with major gaps

The researchers argue that Labour’s approach is part of almost a decade of increasingly active government policy on AI, stretching back through the Conservative governments of Theresa May, Boris Johnson and Rishi Sunak. They describe this pattern as “hyperactive incrementalism” - characterised by short-termism, fragmentation, limited evaluation and repeated policy initiatives.

While the UK has developed an internationally significant AI sector, the researchers say this should not be confused with widespread adoption of AI across the economy.

Successive governments have focused heavily on developing the UK’s AI sector, they argue, but have been less successful at encouraging businesses and public services across the country to adopt AI. The result is a significant gap between the Government’s ambitions for AI and the infrastructure, skills and organisational capacity needed to deliver them.

AI is not a ‘magic bullet’

The researchers argue that there is currently little evidence that AI can, by itself, deliver the broad improvements in productivity, government efficiency and public services envisaged by policymakers.

They also warn that rapid AI expansion could create new problems, including threats to data protection and civil liberties, surveillance, deskilling and unemployment, and increased environmental pressures.

What the researchers say

“AI adoption is currently concentrated in the businesses, sectors and regions that are already among the most productive,” said Darcy Luke from The University of Edinburgh’s BRAID (Bridging Responsible AI Divides) Research Programme. “Without policies that encourage much wider adoption, there is a real risk that AI will reinforce existing inequalities rather than reduce them.”

The researchers conclude that while Labour’s plans represent the most comprehensive attempt by a UK Government to harness AI, the scale and depth of the barriers involved mean that AI may ultimately become “another problem for an already problem-laden government, rather than the solution it is hoped to be.”

Publication details

The paper was published in the journal The Political Quarterly.

DOI:

The Mental Health Digital Innovation (MHDI) workstream has been launched as one arm of the UK Government’s Mental Health Goals Programme as a new national initiative designed to accelerate the infrastructure and development to support adoption of digital technologies that improve mental health outcomes across the UK.

Despite rapid advances in digital technologies, many promising mental health tools struggle to move beyond pilot projects and achieve widespread adoption. Fragmented infrastructure, complex procurement processes, lack of demand signalling, unclear reimbursement pathways and limited coordination between stakeholders have created significant barriers to innovation reaching patients and services at scale. MHDI has been established to build practical pathways that help digital innovations move from development and evaluation into routine care.

brings together people with lived experience of mental health problems, clinicians, industry partners, innovators, researchers and investors to create a more connected and effective ecosystem for digital mental health innovation.

The MHDI workstream is being led by the University of Manchester, with workstream leads Professor Pauline Whelan (University of Manchester, CareLoop Health Ltd) and Dr Trina Histon (Director of Percolating Health) who will work closely with partners: H, (MH-TRC), , NHS organisations, academic institutions, industry partners and people with lived experience of mental health conditions.

MHDI's mission is to make it easier to design, test, adopt and scale digital mental health technologies across the UK.

The initiative will support a broad range of innovations, including digital technologies, digital mental health interventions, digital therapeutics, remote monitoring tools, data-driven decision support systems, wearable technologies and emerging approaches that can improve mental health care and research.

Central to MHDI's approach is the belief that people with lived experience of mental health conditions must be involved throughout the innovation pathway. By creating stronger partnerships between service users, industry, researchers and healthcare providers, MHDI aims to ensure future digital solutions are both clinically effective and meaningful to the people who use them.

The programme will focus on:

• Developing user-centred, industry-aligned digital infrastructure and services.
• Creating clearer pathways for procurement, reimbursement and implementation.
• Supporting NHS organisations through practical implementation guidance and digital navigation support.
• Accelerating the adoption of proven technologies across health services.
• Encouraging sustainable investment models that combine public and private sector support.
• Strengthening the UK's position as a global leader in digital mental health innovation.

For innovators, MHDI will help simplify engagement with the NHS by improving access to guidance, partnerships, investment opportunities and routes to scale.

For NHS organisations and clinical teams, the initiative will promote coordinated national support, reduce duplication of effort and provide practical assistance for adopting new technologies effectively.

For people and communities, MHDI will ensure that more high-quality digital mental health solutions reach those who need them, are easier to access and are better integrated into care pathways.

The initiative has been shaped by extensive engagement with stakeholders and recommendations emerging from national workshops on digital mental health implementation. These recommendations highlight the need for a clear national digital mental health strategy, stronger integration of lived experience, enhanced evaluation approaches and greater support for workforce capability.

By creating clearer pathways for adoption and fostering collaboration across sectors, MHDI aims to remove longstanding barriers to innovation and help establish the UK as a leading destination for digital mental health research, development and implementation.

For more information and future updates on Mental Health Digital Innovation, visit the MHDI or follow on LinkedIn.

Key findings

• Urban canals reduce daytime temperatures by an average of around 0.8°C within their immediate surroundings, typically 20–50 metres away from the water
• Cooling is strongest during spring and early summer, reaching around 1.2–1.4°C
• During heatwaves, canals can lower nearby temperatures by 1.5–2.3°C
• The cooling effect substantially reduced the number of hours when people in the vicinity of canals would experience moderate and high heat stress
• Around 6.2 million people live within one kilometre of Britain's urban canal network, meaning millions could potentially benefit from these cooling effects

Using a new energy balance model, developed by researchers in the Geography, Planning and Engineering departments, the research simulated the thermal behaviour of more than 2,300 canal sections across Great Britain and Ireland over an entire year.

The researchers found that while canals produce a small warming effect overnight because water retains heat longer than surrounding surfaces, this effect is relatively minor compared with the cooling benefits during the day.

Improving health and wellbeing

The researchers also assessed how canals affect thermal comfort during hot weather.

Their modelling showed that incorporating the cooling effect of canals reduced the number of hours classified as posing moderate heat risk by around 58%, while hours of high heat risk fell by around 74%. In many locations, canals eliminated periods of extreme heat risk altogether, although the researchers caution that this is partly counter-balanced by rising humidity, which also influences people's comfort during hot weather.

The findings suggest canals could help reduce heat-related illness, improve wellbeing and encourage people to stay active and walk and cycle during hotter weather, in turn allowing access to nature and reducing carbon emissions through active transport.

"As climate change makes heatwaves more frequent and intense, cities need every available tool to help people stay safe and comfortable,” said lead author Dr Matt Tomkins. “Our research shows that canals, which were originally built to power the Industrial Revolution, could now play an important role in helping cities adapt to climate change.”

"The cooling effect is modest on an average day, but during heatwaves it becomes much more significant, reducing nearby temperatures by more than two degrees in some locations. Even relatively small reductions like these can make an important difference to people's health and wellbeing during periods of extreme heat."

Supporting climate-resilient cities

The researchers say that alongside urban heat regulating services, which have been estimated to provide economic benefits of by reducing losses in labour productivity caused by hot days, the studied canals could play a role in reducing carbon emissions, both through enabling active transport during hotter periods and potentially reducing the demand for energy-intensive air-conditioning.

“Accessible blue and green spaces result in wider health and wellbeing benefits for society” says co-author Dr. Joanne Tippett. “The cooling that canals offer could help more people to stay active and access these spaces even during hot days. This highlights the importance of not only protecting our urban canals, but also thinking about how to increase signposting and access, connectivity with other green infrastructure, and wider awareness of these vital networks of urban cooling”.

They emphasise that canals are not a complete solution to rising urban temperatures, but argue they should form part of a wider package of climate adaptation measures alongside parks, trees, sustainable drainage and other forms of green and blue infrastructure.

The study also provides a new modelling approach that could be applied more widely to assess how similar waterways contribute to cooling in other cities around the world, and to complement insights gained from field-based measurements, modelling, and satellite-based observations.

Publication details

The study was published in Nature Communications.

Funding, data, and support for this project was provided by the Canal and River Trust, with the research generously supported thanks to funds raised by Postcode Lottery players.

DOI:

Building on more than a decade of success, brings together five leading northern universities to support healthcare professionals to become the next generation of research leaders.

Director of Forward North Professor from the University of Manchester, said: "I am delighted that we can continue to offer doctoral training fellowships for healthcare professionals over the next five years.

“By working together across the North, we can help more healthcare staff develop research careers and generate the discoveries and innovations needed to improve patient care and health outcomes."

The renewed programme builds on a strong track record of supporting healthcare professionals to undertake PhDs.

It will also introduce new pre-doctoral opportunities to help more people enter research, provide enhanced support for early career researchers, and strengthen partnerships with organisations including the Nuffield Foundation, STEM Learning and the Francis Crick Institute.

Through expert mentoring, interdisciplinary collaboration, industry engagement and specialist training, Forward North will help develop future research leaders equipped to tackle some of the North's biggest health challenges.

A virtual launch event will take place on 18 August from 11.30am to 1pm, providing information about the next round of fellowship applications and an opportunity to ask questions.

You can join the event

The researchers analysing the records of more than 1.4 million people found that social prescribing – where patients are referred to support such as community groups, exercise schemes or financial advice – was linked to an early rise in healthcare use, followed by a small drop in GP appointments.

The study was funded by the National Institute for Health and Care Research (NIHR) and published in eClinical Medicine.

Social prescribing became a key part of NHS plans in 2019, with thousands of link workers recruited across England to connect patients with community support.

It has become a central part of NHS efforts to address the wider social factors that influence health, including loneliness, housing problems, debt and inactivity.

Despite the scheme's rapid expansion, until now there has been little robust evidence showing whether social prescribing affects NHS demand, healthcare use or costs.

The findings come from one of the largest studies of its kind, using anonymised NHS records from the Clinical Practice Research Datalink (CPRD), covering around a quarter of England’s population.

The research team compared 168,699 patients referred to social prescribing between July 2019 and April 2022 with more than 1.3 million similar patients who were not referred.

In the first six months after referral, patients receiving social prescribing had an average of 2.25 more contacts with healthcare services than those who were not referred – a rise of around 24%.

The increase was largely driven by more visits to primary care services and attendance at planned outpatient appointments in hospitals.

This, they say, may reflect patients becoming more proactive about managing their health and seeking help for conditions that might previously have gone untreated.

But by one year after referral, the picture had changed.

The increase in healthcare contacts had fallen substantially and patients referred to social prescribing were attending slightly fewer GP appointments than those who had not been referred.

Despite the higher number of healthcare interactions, the overall cost to the NHS was virtually unchanged.

The study found healthcare costs were less than 0.1% higher among referred patients, a difference researchers described as clinically insignificant.

The small increase in spending was mainly linked to additional secondary care admissions.

Lead author from The University of Manchester said: “Our findings suggest that social prescribing may encourage people to engage with healthcare services in the short term, particularly with planned and preventative care.”

“Importantly, we found that this increase did not translate into meaningful increases in overall healthcare costs, and by one year patients were having slightly fewer GP appointments.”

“This could indicate that social prescribing helps direct people towards more appropriate forms of support while reducing pressure on general practice.”

She added: “Better integration between social prescribing data systems and electronic health records will be needed to understand whether patients who fully engage with these services gain even greater benefits.”

Charlotte Osborn-Forde , CEO of the National Academy for Social Prescribing added: "There is now strong evidence that social prescribing leads to improved wellbeing and that it can support people with a range of health conditions.

"This research provides useful analysis of how referrals to link workers affected healthcare use during the COVID pandemic, potentially leading to a long-term fall in GP appointments.

"It also shows the need for further exploration of how to account for the unmeasured social needs that lead to a referral for social prescribing, and better data on support received after the referral, to track the impact of social prescribing more robustly."

• The paper "Changes in healthcare use and cost associated with referrals to social prescribing link workers in England: a matched case-control cohort study” is published in eClinical Medicine. DOI

And opening windows during hot weather, they show, almost certainly exacerbates the problem of indoor air pollution caused by the fires.

The University’s Canalysed real time indoor air-quality records from 23 Greater 91ֱ�� homes monitored between 1 and 26 July 2026, during two periods of wildfire activity in the nearby Pennine hills.

Every monitored home in the Cystic Fibrosis Trust funded study exceeded the World Health Organization’s 24-hour guideline for fine particle pollution on 17 July, when outdoor smoke levels peaked.

The preliminary analysis, which has not yet undergone peer review, also showed when households opened widows as temperatures climbed to over 33C , the problem seemed to get worse.

, based at The University of Manchester and the National Centre for Atmospheric Science (NCAS), led the analysis of PM2.5, particles produced by smoke small enough to travel deep into the lungs, where they can harm health.

During the wildfires, overnight bedroom PM2.5 spiked from an average of 2.7 micrograms per cubic metre to 7.8 with windows closed and 11.8 with windows open. Closing windows reduced exposure, but levels remained 2–4 times higher than normal.

In some homes, concentrations in the bedroom overnight rose to well over 100 micrograms per cubic metre, many times higher than the levels normally recorded in those homes.

Levels of indoor-generated pollution, such as volatile organic compounds and carbon dioxide, actually fell during this period as participants opened windows to cool their homes, allowing the outdoor pollution in.

The researchers say that following the UK Health Security Agency’s guidance on wildfire smoke by staying indoors and closing windows should help reduce the pollution.

Levels, they say, did not rise as much in homes where windows appear to have remained closed though this did not prevent all outdoor smoke pollution from getting in.

The researchers are also currently working on a Greater 91ֱ�� Local Innovation Partnership funded study, the Retrofit Advanced Materials and Manufacturing Innovation Centre to investigate measures that may help further combat indoor pollution, for example during periods of wildfire, and during intensely hot weather.

That could include the use of air purification and integrated ventilation systems, improved sleeping arrangements and other measures.

One of the researchers from The University of Manchester, said: “These findings show the difficult challenges that people face during periods of wildfires and high environmental temperatures.

“Following the simple but often repeated instruction of going indoors and shutting the windows will only give you some protection from wildfire smoke, and keeps heat in the home. Both smoke and heat can make breathing worse for those with chronic lung conditions.

“During July’s fires, in every home we monitored we found the effects of smoke was present indoors at potentially harmful concentrations levels, especially during periods when the heat forced people to open windows.

“We saw this in homes up to 60km away from the wildfires on the moors outside 91ֱ��.”

, lead Environmental researcher for the group said: “The findings support advice to close windows while smoke levels are high, but show that this cannot completely prevent smoke infiltration and may increase the risk of overheating.

“The challenge is that this advice can be difficult to follow during very hot weather, particularly in homes that are prone to overheating.

“We need clearer, evidence-based guidance that helps households reduce exposure to both smoke and heat. I hope this new data can support these decisions.

“We are now investigating practical measures, including air filtration and approaches to keeping homes cool, so that people - especially those with existing respiratory conditions - have better options during future extreme events such as these.”

Dr Bannan added: “Wildfire smoke contains tiny particles and gases that can irritate the lungs and make respiratory conditions such as cystic fibrosis, asthma and COPD worse.

“Exposure to wildfire smoke can increase symptoms including coughing, wheezing, breathlessness and chest tightness, and may trigger severe flare-ups that require medical treatment.

“That is why people with existing respiratory diseases as well as children, older people and other immunocompromised people are also at greater risk of respiratory infections, hospitalisation and other serious health complications during wildfire events.”

Dr Sharon Weinberg, a clinical research fellow at The University of Manchester added:

said: “While our study examines the impact of PM2.5 on lung health, poor air quality affects far more than the lungs.

“Elevated PM2.5 exposure is known to increase the risk of cardiovascular events—including heart attacks, strokes, and thrombosis.

“It is also associated with headaches and migraines, highlighting that the health consequences of air pollution extend well beyond people with chronic respiratory disease.”

Laura Beattie, who has cystic fibrosis and is taking part in the study, said: “I found it really hard during the heatwave and the wildfires.

“You could see and smell the smoke for days, and it made my breathing worse. I was more breathless, and had to restrict myself to staying indoors. I also noticed that my sputum went dark from the smoke - I've never seen it like this before.

“We can all see wildfires becoming more common, and research like this is so important for people like me with chronic lung conditions.”

• The is still recruiting people with CF across the UK, including in the 91ֱ�� and Merseyside regions where the air quality monitoring is included as an optional part of the study. The Pulse-CF Innovation Hub is part of the Translational Innovation Hub Network for CF Lung Health & Infection, funded by Cystic Fibrosis Trust and LifeArc. Though these findings are not yet peer reviewed, the research team felt it was in the public interest to release the figures.

Collecting rainwater from rooftops and using it to spray buildings during hot weather could help cities cut air conditioning use, lower urban temperatures and lessen the impact of heatwaves, according to new research from The University of Manchester.

Cities around the world are facing rising temperatures, putting pressure on public health, infrastructure and energy systems. As people rely more on air conditioning to stay cool, energy demand increases and waste heat released from buildings can make urban areas even hotter.

Urban watering technologies are becoming important ways for reducing extreme heat in cities, but their use is often limited by the availability of water.

How does rainwater keep cities cool?

In the study, published in , researchers used process-based numerical simulations and Artificial Intelligence (AI) to test a system that stores rainwater collected from rooftops and automatically sprays it onto buildings during hot weather.

Using Tokyo as their case study, they found that cooling rooftops, the system reduced the amount of energy needed for air conditioning. The cooler roofs transferred less heat into buildings, while lower air conditioning use meant less waste heat was released into the city. Together, these effects helped reduce urban temperatures, cutting the number of heatwave days overall and lessening the intensity of extreme heat events.

What do the reserchers say?

Lead author Dr Zhonghua Zheng, Co-Lead for Environmental Data Science & AI at 91ֱ�� Environmental Research Institute (MERI) and Senior Lecturer (Associate Professor) in Data Science and Environmental Analytics at The University of Manchester, said: "Cities around the world are facing growing challenges from extreme heat. Air conditioning can help keep people safe and comfortable, but it also consumes large amounts of energy and releases additional heat into the urban environment.

"Our study shows that harvesting rainwater from roofs and using it strategically for cooling could provide a practical way to reduce both energy demand and urban temperatures.

"What is particularly encouraging is that the benefits become even greater during hotter years, suggesting this approach could become increasingly important as the climate continues to warm.”

How would the rainwater sprinklers work?

The study suggests that when the sprinklers switched on - for example, when the roof reached a certain temperature - had a greater impact than either the size of the tank or the amount of water applied. The researchers also found that bigger is not always better. Very large tanks delivered only modest additional reductions in energy use and extreme heat, while applying extra water did not always lead to more cooling because some of it remained on the roof instead of evaporating.

The researchers say the approach could help local authorities and urban planners evaluate how rainwater-based cooling systems might work in their own regions while balancing practical considerations such as cost, water availability and local regulations.

Can rainwater cooling help with other urban challenges?

As cities continue to grapple with rising temperatures, the team believes roof-based rainwater cooling systems could form part of a wider suite of urban climate adaptation measures designed to improve resilience and protect public health.

Junjie Yu, PhD researcher at The University of Manchester, added: “The rainwater tank also provides an additional co-benefit on reducing the extreme urban runoff. This approach exemplifies a ‘natural solution to natural challenges’, in which rainwater serves as a natural resource to mitigate both thermal stress and hydrological extremes.”

Published in on 5 August, the University of Manchester and University of Connecticut team has revealed how a little-known protein helps keep one of the body's most powerful biological signals under tight control.

Their findings could eventually help researchers develop new ways to tackle conditions linked to fibrosis, a process in which excessive scar tissue forms in organs and prevents them from working properly.

Fibrosis can affect the lungs, liver, kidneys and other organs, and is thought to contribute to millions of deaths worldwide each year.

At the centre of the discovery is a signalling molecule called transforming growth factor beta, or TGFβ.

This molecule plays a vital role in the body, helping cells grow, communicate with each other, respond to injury and repair damaged tissue.

However, when there is too much active TGFβ it can trigger the build-up of scar tissue, contributing to a range of serious diseases.

Because of its powerful effects, the body normally keeps TGFβ locked away in an inactive state until it is needed.

They used advanced imaging, called cryo-electron microscopy, engineered human cell lines and 3 dimensional�� computer simulations to reveal how a key protein regulates TGFβ activity.

The study revealed for the first time how a protein known as latent TGFβ-binding protein 1, or LTBP1, helps build and stabilise this storage complex.

The researchers discovered that LTBP1 does far more than simply hold TGFβ in place.

Instead, it acts as a key regulator, helping to keep the molecule safely stored while also influencing how it is released.

The team showed how LTBP1 forms a crucial connection with TGFβ and helps determine how much physical force is needed before the signalling molecule can become active.

This mechanical control system ensures that TGFβ is only switched on in the right place and at the right time.

The findings provide an important new understanding of how the body regulates one of its most influential signalling pathways.

The scientists believe the work could help guide future efforts to develop treatments that selectively control TGFβ activity in disease.

Lead author Professor Clair Baldock from The University of Manchester said: “TGFβ is one of the body's most important signalling molecules because it influences how cells grow, communicate and repair tissue.

“But when its activity is not properly controlled, it can contribute to diseases such as fibrosis, where excessive scar tissue damages healthy organs.

“Our study has revealed in unprecedented detail how LTBP1 helps store and regulate TGFβ, and how the structure of this protein complex affects the forces needed to activate it.

“By understanding this process more clearly, we have uncovered a new layer of biological control that could help researchers develop more precise therapies in the future.”

“We�� hope our discovery will provide a foundation for future studies aimed at preventing harmful scarring while preserving the body's normal repair mechanisms.”

• The Structural basis for the contribution of latent TGFβ binding protein to TGFβ latency and activation is published in on 05/08/26 DOI
• Image of microscope created with AI
• The study was funded by the Biotechnology and Biological Sciences Research Council and The Wellcome Trust.

Their discovery, published in the world leading journal on 04/08/26, centres on activated dendritic cells, a specialised population of immune cells that orchestrate the body’s attack on cancer.

To make the discovery, the researchers developed the first mouse models capable of specifically labelling or removing activated dendritic cells.

This allowed them to determine exactly how activated dendritic cells contribute to anti-cancer immunity.

The models are expected to accelerate research into activated dendritic cells across cancer, infections and autoimmune diseases.

Until now, scientists have struggled to understand precisely how activated dendritic cells contribute to anti-cancer immunity because suitable models did not exist.

Using the new models, the team showed that activated dendritic cells are indispensable for effective anti-cancer immune responses.

Without them, cancer-killing T cells could neither be efficiently activated nor maintain their strength once inside tumours.

As a result, both spontaneous immune control of cancer and the efficacy of immunotherapy were impaired.

First author Maria Koufakis said: “Modern immunotherapies rely on strong and coordinated immune responses, yet many people still do not benefit from these treatments.”

“If we can find ways to boost activated dendritic cells, we may be able to strengthen the immune system’s response to cancer and help more patients benefit from immunotherapy, including some whose cancers currently resist treatment.”

Senior author said: “Activated dendritic cells do not just launch the anti-tumour immune responses, they are also essential for sustaining them within the tumour itself.

This changes how we think about their role and opens up new opportunities to improve cancer immunotherapy.”

The work was funded by Cancer Research UK, with additional support from the European Molecular Biology Organization and the Italian Association for Cancer Research UK.

Research Information Manager at Cancer Research UK, Dr Marianne Baker, said: "Immunotherapies that harness our immune system to beat cancer are saving lives, but we don't yet understand why they work for some people and not others.

“The models developed as part of this study could help scientists unlock ways to boost these revolutionary treatments via dendritic cells, a type of immune cell.

“We need more research to get there, but this work could help to solve unanswered questions in cancer immunotherapy and beyond."

• Image: ��Ai-rendered 3D��representation of activated dendritic cell with a coral-coloured nucleus, highlighting the use of the new reporter model. The nucleus of the cells of interest has been labelled scarlet.

• CCR7⁺��activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity, published in Immunity is available . DOI DOI:��

The research, and funded by the NIHR Patient Safety Research Collaboration (PSRC): Greater 91ֱ��, is the largest review of its kind and analysed evidence from 74 clinical trials conducted over 23 years.

The review found that digital patient safety tools in primary care can be beneficial - particularly when they combine multiple features, such as automated prescribing or missed test reports for doctors alongside digital communication tools for patients.

According to the findings, digital interventions currently being used in clinics:

• improved medication safety by 46% when compared to usual care, reducing high-risk prescribing and dosing errors
• improved non-medication safety processes by 77% when compared to usual care, including faster diagnostic checks and more timely laboratory monitoring
• reduced physical patient harm and adverse events by 17% when compared to usual care, helping to prevent unnecessary hospital admissions, asthma attacks and serious adverse drug reactions

The study highlights several specific digital technologies that were shown to enhance patient safety, improve communication and treatment decisions, and reduce diagnostic delays.

One of the digital tools highlighted is the UK-developed PINCER programme, which uses electronic health records to help GPs and pharmacists identify and prevent incorrect prescribing. The programme showed that digital systems can improve safety at scale while supporting better use of NHS resources.

The success of PINCER has also inspired new digital innovations, such as the , develoved through a partnership between researchers from the NIHR PSRC: Greater 91ֱ��, NHS partners and industry. SMASH is a digital medication safety tool that helps clinicians identify and address medication risks more quickly and consistently. Early evaluation in Salford, for example, covering more than 235,000 patients across 43 GP practices, showed a 40% reduction in hazardous prescribing within 12 months.

By embedding evidence-based safety indicators into routine clinical practice, SMASH helps clinicians identify and address medication risks more quickly and consistently. Early evaluation in Salford, for example, covering more than 235,000 patients across 43 GP practices, showed a 40% reduction in hazardous prescribing within 12 months.

The systems that work best

Researchers found that the greatest improvements came from integrated systems that combined multiple features, such as clinical decision support tools, patient communication systems and audit and feedback mechanisms.

For example, where Clinical Decision Support Systems (CDSS) - which prompt GPs with real-time alerts about drug interactions or missing tests - were paired with Audit and Feedback (A&F) systems, which allow clinics to regularly review their safety data.

In addition, tools that featured patient-facing elements - such as automated text reminders or patient portals - had a positive impact on non-medication safety, making patients nearly 3 times more likely to receive timely investigations and follow-up care.

However, the review found that technology alone is not enough. More than 40% of the studies reported implementation barriers, including alert fatigue - where clinicians are overwhelmed by excessive computer pop-ups - and software that disrupted busy GP consultations. The most successful interventions were those that fitted naturally into existing clinical workflows and were supported by training, relationships and organisational engagement.

Lead researcher, Dr Jung Yin Tsang, from The University of Manchester, said:

“Our research suggests that the future of safer care will not be built on software alone, but on how well digital tools work alongside patients, clinicians, pharmacists and healthcare teams.

"To unlock their full potential across the NHS, we must move away from isolated, complex software. Policymakers and developers must focus on intuitive, joined-up systems that fit naturally into a GP’s busy workday without adding to their administrative burden."

Professor Mike Lewis, NIHR Scientific Director for Innovation, said:

“This NIHR-funded evidence demonstrates how well-designed digital technologies can improve patient safety in everyday care. It highlights the importance of investing in robust research into digital technology so the NHS adopts the systems which are safe and proven to improve outcomes for patients and staff.”

Health and Social Care Minister Baroness Merron, said:

“This research shows the real difference that well-designed digital technology can make to patient safety, helping clinicians reduce medication errors, identify risks earlier and ensure patients receive timely care.

“As we deliver our 10-Year Health Plan, we are transforming the NHS through better use of technology, so staff have the tools they need to provide safer, more joined-up care closer to home. Research like this helps ensure we invest in digital innovations that deliver better outcomes for patients and support our workforce.

"By backing high-quality research and adopting technologies that are proven to work, we can build a modern NHS that is safer, more efficient and provides the highest quality care for every patient."

--

The paper Digital patient safety interventions in primary care: a systematic review and meta-analysis was published in BMC Medicine and is .

Read the full NIHR news story: .

When it is done well, in other words when your yogurt pots (polypropylene, PP) are sorted from your milk jugs (high density polyethylene), mechanical recycling is the most environmentally positive way to turn plastic waste into new products in a circular plastics economy, turning pots into pots and jugs into jugs.

However, poor sorting can lead to mixing polyolefins together, changing the way that the plastic degrades during the recycling process.

While well understood for polyethylene, the study, published in , focuses on what happens when PP is mixed with HDPE. Researchers found that contaminants act as stress aggregators, and that the phase separation caused by contamination weakens the material. While HDPE can tolerate a few percent contamination, even 1% of HDPE in PP alters the degradation mechanism.

The result of this contamination, even at this small scale, is a recyclate with radically altered physical properties, a change which impacts structure-property relationships and reduces the overall performance of the material, especially important in the context of their industrial reuse.

Researchers argue that while efforts have been made to normalise polymers based on processing history and end-use application, approaches like these only consider a limited number of material grades and do not represent the broad range of polyolefin grades and blends.

They suggest that cross-contamination needs better analytical tools that can serve as quality control in industrial processes, evidencing the need for better sortation in household and industrial recycling.

This paper was published in the journal: ChemCircularity

Full title: Measuring the impact of cross-contamination on quality in polyolefin blends

DOI:

The findings of the study, funded�� by the National Institute of Health and Care Research (NIHR) suggest the wraps may not be the best first-line option for patients receiving strong compression therapy.��

Venous leg ulcers affect thousands of people and can take months to heal, causing pain, reduced mobility and a significant burden on healthcare services.��

Strong compression is an important treatment for people with venous leg ulcers, to improve blood flow in the lower leg and support healing.��

It can be provided in different ways, including bandages systems that can have two or four layers, compression stockings that have two layers and adjustable compression wraps that fasten around the leg with Velcro-style straps.��

All these compression approaches aim to deliver the same level of compression but differ in how they are applied, how easy they are to use and how comfortable people find them.��

Wraps have become increasingly popular because they can be adjusted and, in some cases, self-applied by people with leg ulcers or those around them.�� However, there has been limited high-quality evidence comparing compression wraps with other commonly used strong compression treatments.��

The researchers carried out a large randomised controlled trial involving 637 adults receiving care at 33 mainly community sites across the UK.��

Participants were assigned to be offered either compression wraps, two-layer compression bandages, or established evidence-based compression treatments (four-layer bandages or two-layer compression stockings)��

The researchers found that ulcers healed more slowly in patients offered compression wraps than in those offered established evidence-based compression treatments.��

Patients receiving compression wraps also appeared to heal more slowly than those treated with two-layer compression bandages, although this difference was not statistically significant.��

The study found that two-layer compression bandages performed similarly to established evidence-based compression treatments.��

The findings provide some of the strongest evidence to date comparing commonly used compression therapies for venous leg ulcers.��

A separate companion process evaluation found patients liked compression wraps because they were comfortable, easy to adjust, and could be removed for showering,��

However, these same features may also mean that people are more likely to loosen or remove the wraps, potentially reducing the amount of therapeutic compression delivered and helping explain the slower healing observed in the trial.��

Together, the studies suggest compression wraps should not routinely be the first choice for most people with venous leg ulcers.��

However, they may still be appropriate for some patients where comfort, independence or self-management are particularly important, provided patients receive clear advice on maintaining effective compression.��

Jo Dumville, Professor of Applied Health Research from the University of Manchester said: “Venous leg ulcers can have a major impact people’s quality of life and place a significant burden on healthcare services, so it is important that health professionals have robust evidence to guide treatment decisions”.��

“Our study compared three commonly used strong compression approaches in a real-world NHS setting and suggested that�� that compression wraps do not improve healing times when compared with established evidence-based treatments.”��

Catherine Arundel, Senior Research Fellow at the University of York said: “While some uncertainty remains, these findings suggest that compression wraps are unlikely to offer a healing advantage as a first-line treatment”.��

“The results will help clinicians, patients and healthcare providers make informed decisions about the most appropriate therapies for managing venous leg ulcers."��

• The paper Compression therapies for venous leg ulcers: The VENous Ulcer 91ֱ�� 6 (VenUS 6), an open, multicentre, randomised clinical trial is published in PLOS Medicine
• The companion process evaluation Compression therapies for the treatment of venous leg ulcers: a mixed method process evaluation in a randomised controlled trial, VenUS6�� is published in Trials