<![CDATA[Newsroom University of Manchester]]> /about/news/ en Tue, 22 Oct 2024 22:34:48 +0200 Mon, 02 Sep 2024 08:54:06 +0200 <![CDATA[Newsroom University of Manchester]]> https://content.presspage.com/clients/150_1369.jpg /about/news/ 144 What’s behind the large rise in food allergies among children in the UK? /about/news/whats-behind-the-large-rise-in-food-allergies-among-children-in-the-uk/ /about/news/whats-behind-the-large-rise-in-food-allergies-among-children-in-the-uk/656524

The number of people in England with food allergies has more than doubled between 2008 and 2018, a reveals. The researchers, from Imperial College London, found that rates are highest among preschool children, with 4% having a “probable” food allergy.

They also found that a third of those people at risk of anaphylaxis – a life-threatening allergic reaction – don’t carry adrenaline autoinjector “pens”, such as EpiPens. People in deprived areas were found to be less likely to have been prescribed these life-saving injectors.

The true number of people with food allergies has been difficult to establish, with estimates varying between . This is because several methods are used to estimate the frequency of food allergies, including using either the number of prescriptions of adrenaline pens, self-reporting, or blood tests to identify telltale antibodies.

Self-reporting is the least reliable method because many people confuse food intolerance with allergy, as is evident from a by the UK’s Food Standards Agency.

Of the over 30% of adults who reported an adverse reaction to foods, only 6% were subsequently confirmed to have a true food allergy. To bridge this gap in understanding how common food allergies are, the new study from Imperial College took a much broader approach to better estimate the incidence of food allergy.

Population healthcare data from over 7.5 million people in England and a combination of clinical criteria were used to identify people with food allergies in these health records.

People were considered to have an allergy if doctors indicated they had either had a possible or probable allergy, or if they had been prescribed an adrenaline pen, or both. Using this combination, the number of people with food allergies was shown to have doubled in a decade. Curiously, since 2018, levels have plateaued somewhat at around 4% in preschool children, 2.4% in school-aged children, and under 1% in adults.

The study, published in The Lancet Public Health, used a broad range of criteria to identify people with food allergies. Not all cases were confirmed by medical professionals using additional tests, such as the presence of antibodies in blood or food-challenge tests where people are given increasing amounts of certain foods to see if an allergic reaction occurs.

Some types of food allergy may have been missed, such as . This occurs when people with specific pollen allergies eat some raw foods, including certain stoned fruits, that cause mild irritant symptoms, such as itching of the mouth. Still, there are important questions as to why food allergies have been rising, and why they may now be plateauing.

Puzzling

The trend in the increased rate of allergies in developed countries has puzzled scientists for years. The is one theory that may account for the growing incidence of chronic conditions such as allergies.

This hypothesis considers the role of the microbiome (the collection of helpful bacteria, fungi and viruses that live in and on us), infections and the environment in shaping our immune response and causing it to misfire.

Evidence to support this theory is accumulating. For example, studies show that in early childhood as the immune system and microbiome are developing is linked to a greater likelihood of allergy in later life.

Pollution exposure can also enhance the risk of allergy and .

The food we were exposed to in early life may be important in determining if we develop an allergy. from the UK government about avoiding early exposure to peanuts and eggs may inadvertently be linked to the rise in food allergy to peanuts and eggs.

Conversely, that early exposure before the age of five to is a reduced likelihood of developing an allergy.

The advice in the UK to avoid peanuts and eggs during pregnancy and early childhood was changed in , but the trials showing the positive effects of early exposure to eggs and peanuts were only published in 2015 and 2016. However, it is possible that the plateauing incidence of food allergy cases is linked to changes in advice and the published infant food exposure trials.

Diagnosis is only part of the story. People also need to be able to effectively manage their condition. This requires patients to have access to the right advice and support from experts, such as dietitians, as well as the drugs needed to halt an anaphylactic attack.

For babies diagnosed with a food allergy, there is now ) that incrementally reintroducing the food that causes the allergy can retrain the immune system and might help the child overcome their allergy. However, this must only be done under the guidance of a medical team.

The new study showed that allergy care was largely managed at GP practices in England. However, GP clinics may lack the specialist resources needed for proper allergy support, such as safely re-introducing foods.

It is clear that people in the UK with allergies need better support.The Conversation

, Professor in Immunology,

This article is republished from under a Creative Commons license. Read the .

]]>
Mon, 02 Sep 2024 07:54:06 +0100 https://content.presspage.com/uploads/1369/73d13a9d-f174-4baa-af4e-850186ebe88f/500_stock-photo-set-of-allergic-food-isolated-on-white-432815716.jpg?10000 https://content.presspage.com/uploads/1369/73d13a9d-f174-4baa-af4e-850186ebe88f/stock-photo-set-of-allergic-food-isolated-on-white-432815716.jpg?10000
COVID: why the UK’s autumn vaccine strategy could fail patients /about/news/covid-why-the-uks-autumn-vaccine-strategy-could-fail-patients/ /about/news/covid-why-the-uks-autumn-vaccine-strategy-could-fail-patients/655173

This summer has seen a large – one which is showing potential to be bigger than the 2023 winter wave was.

The current wave has largely been driven by the so-called variants, which have acquired greater immune evasion and ability to enter our cells. The rise in COVID cases has also been a .

COVID is not seasonal, as this current wave is stark evidence of. This is why vulnerable people are given . Nonetheless, most respiratory infections (COVID included) are at . Having access to a COVID booster in the autumn is of great importance, as it protects those who are most vulnerable from severe COVID infections.

The Joint Committee for Vaccination and Immunisation (JCVI) have just published their recommendations for the . Unfortunately, the recommendations they’ve made mean even fewer people will have access to vaccines for free on the NHS this autumn. And, the vaccines that will be made available may not be as effective against the current variants as newer formulations would be. This could leave more patients at risk of potentially serious infection.

The JCVI use a number of considerations in costing their recommendations for vaccine campaigns (although they have not fully released details of their costing model). What is clear is that the main concern is the cost of buying and delivering vaccines to prevent severe disease and deaths.

This year sees even fewer people able to access the vaccine for free on the NHS. The boosters will be offered to those over the age of 65, residents in old-age care homes and people who are at greater risk of catching COVID due to a compromised immune system. The JCVI haven’t advised offering the vaccine to frontline health and social care workers, staff in care homes and unpaid carers or household contacts of immunosuppressed people. Fortunately, the government has agreed to maintain the vaccine this year for .

Reduced vaccine coverage leaves those with regular, close access to vulnerable people unable to reduce their own risk of catching or spreading COVID. Although, it’s possible to purchase vaccines from many pharmacies, this is not cheap – with doses . Many people may not have the resources to pay for one.

Vaccines don’t just lower the risk of severe infection. They may also lower the risk of developing long COVID after an infection . Recent data shows that the risk of developing long COVID from an infection . The most recent Office for National Statistics data also shows are still being reported in the UK. Although fewer new cases are emerging, it’s still a significant number.

Despite the benefit of vaccination on reducing long COVID risk, the JCVI say there’s not enough evidence showing boosters reduce the risk of the condition. This is why they did not into their cost-benefit analysis.

The autumn vaccine campaign will also provide eligible patients with from the Autumn 2023 campaign instead of purchasing new vaccines.

Although using pre-procured doses means less money will be spent on the autumn booster programme, research shows older formulations of vaccines are less effective against variants which emerged after they were developed (such as the ). Modelling suggests they’ll be up to a against severe disease.

Indeed, the , in line with , have recommended boosters be updated to target the JN.1 variants. Several manufacturers have begun preparing updated formulas for . The US’s Food and Drug Administration noted the and requested a modification to vaccines in order to as well.

But even with vaccine modifications being made to it may still be too late, given FLiRT variants are . Recent data suggests the virus is even evolving away from the FLiRT variants with even more .

The fact we’re in a position where we’re using vaccines that may be less effective against current variants is enormously frustrating. Ideally we would be looking to develop or acquire more durable vaccines that confer longer-lasting immunity – such as or that may be more resilient against the ever-evolving virus.

These could potentially have been developed in the UK’s vaccine manufacturing production centre. However, was in 2022. This leaves us lagging well behind other countries, such as , and , which are continuing to invest in developing the next generation of vaccines.

Vaccines, of course, aren’t the only tool we have. We can reduce the impact of infection by widening access to anti-viral COVID drugs (such as Paxlovid). Access to Paxlovid was to be expanded to cover who aren’t eligible for the vaccine (such as people who are obese or have diabetes). But the reality is there aren’t enough supplies and funding to cover the 15 million people that could become eligible – so these plans . Patients currently eligible to access the drug have described difficulty getting hold of this .

Public health measures such as and in buildings could also help lower risk of infection. But again, no money is being invested into making these measures more accessible.

COVID is not just another cold. It still has the potential to cause serious disease – and this threat is not going away anytime soon. Ignoring it isn’t an option, which is why ensuring people still have access to the latest, most effective vaccines is so important.The Conversation

, Professor in Biomedical Sciences,

This article is republished from under a Creative Commons license. Read the .

]]>
Fri, 16 Aug 2024 15:23:13 +0100 https://content.presspage.com/uploads/1369/ad915df3-451c-4840-97d4-8a1fab61f2b4/500_stock-photo-doctor-giving-a-senior-woman-a-vaccination-virus-protection-covid-1892640727.jpg?10000 https://content.presspage.com/uploads/1369/ad915df3-451c-4840-97d4-8a1fab61f2b4/stock-photo-doctor-giving-a-senior-woman-a-vaccination-virus-protection-covid-1892640727.jpg?10000
How the last meal of a 3,000-year-old Egyptian crocodile was brought back to life using modern science /about/news/how-the-last-meal-of-a-3000-year-old-egyptian-crocodile-was-brought-back-to-life-using-modern-science/ /about/news/how-the-last-meal-of-a-3000-year-old-egyptian-crocodile-was-brought-back-to-life-using-modern-science/653898How the last meal of a 3,000-year-old Egyptian crocodile was brought back to life using modern science

What do you think of when you think about ancient Egyptian mummies? Perhaps your mind takes you back to a school trip to the museum, when you came face to face with a mummified person inside a glass case. Or maybe you think of mummies as depicted by Hollywood, the emerging zombie-like from their sandy tombs with dirtied bandages billowing in the breeze.

It might surprise you to know that the Egyptians also preserved .

, my colleagues and I revealed extraordinary details about the final hours in the life of a crocodile that was mummified by the ancient Egyptian embalmers. Using a CT scanner, we were able to determine how the animal died and how the body was treated after death.

To the Egyptians, animals served an , moving between the earthly and divine realms. Hawks were associated with the because they flew high in the sky, closer to the sun (and therefore to the god himself). Cats were linked to the , a brave and ferociously protective maternal figure.

Most animal mummies were created as or gifts.

Animal mummies provide a snapshot of the natural world, taken between approximately 750BC and AD250. Some of these mummified species are in Egypt.

For example, ancient Egyptians would have seen , long-legged wading birds with curved beaks, every day. The birds were mummified in their millions as offerings to Thoth, the god of wisdom and writing. The birds are no longer in Egypt as climate change and the effects of desertification have made them move south to Ethiopia.

Another commonly mummified animal was the crocodile. Although crocodiles lived in the Nile during ancient times, the prevented them from moving northwards towards the delta in lower Egypt.

Crocodiles were associated with Sobek, and the god whose presence signalled the which provided water and nutrient-rich silt to their agricultural land.

Crocodiles were mummified in huge numbers as offerings to Sobek. They were used as talismans throughout pharaonic Egypt to ward off evil, either by wearing crocodile skins as clothing, or by hanging a crocodile over the doors of homes.

Most crocodile mummies are of small animals, which suggests that the Egyptians had the means to hatch and keep the young alive until they were required. reinforces this theory, with the discovery of areas dedicated to the incubation of eggs and rearing of hatchlings. Some were and allowed to die a natural death.

As the crocodiles grew larger, the risk to crocodile keepers increased, suggesting perhaps that larger specimens were captured in the wild and hastily dispatched for mummification. on the mummified remains of larger animals has revealed evidence of inflicted by humans probably as an attempt to immobilise and kill the animal.

What we found

The crocodile mummy in our study holds evidence to suggest how these animals might have been caught. The mummy is held in the collection of , UK, and measures 2.23 metres long. In May 2016, the large crocodile mummy, which formed part of a wider study by a team of researchers I work with from the University of Manchester, was transported to the to undergo a series of radiographic studies.

Medical imaging techniques allow researchers to study ancient artefacts without , the way that studies of mummies once did.

X-rays and CT scans showed that the animal’s digestive tract was filled with small stones known as . Crocodiles often swallow small stones to help them and regulate buoyancy. The gastroliths suggest the embalmers did not carry out evisceration, the process of removing the internal organs to delay putrefaction.

Among the stones, the images also showed the presence of a metal fish hook and a fish.

The study suggests that large, mummified crocodiles were captured in the wild using hooks baited with fish. It adds weight to the account of , who visited Egypt in the 5th century BC and wrote about pigs being beaten on the banks of the river to lure the crocodiles, which were caught on baited hooks placed in the Nile.

Unlike many aspects of life in ancient Egypt, little information was recorded relating to animal worship and mummification. Classical writers who travelled to the country remain some of our best sources of information.

Colleagues from the helped replicate the hook in bronze, the metal most likely to have been used to create the ancient original, for display alongside the crocodile mummy.

Modern technology is helping us to learn more and more about our ancient past. I can only imagine what secrets technology might help reveal in the future.The Conversation

, Lecturer in Biomedical Egyptology,

This article is republished from under a Creative Commons license. Read the .

]]>
Fri, 02 Aug 2024 13:19:32 +0100 https://content.presspage.com/uploads/1369/092890a1-54f1-4c81-97d4-0c6fa51df6ff/500_crocinct.png?10000 https://content.presspage.com/uploads/1369/092890a1-54f1-4c81-97d4-0c6fa51df6ff/crocinct.png?10000
People with dementia in care homes aren’t getting enough help with their hearing loss – new survey /about/news/people-with-dementia-in-care-homes-arent-getting-enough-help-with-their-hearing-loss--new-survey/ /about/news/people-with-dementia-in-care-homes-arent-getting-enough-help-with-their-hearing-loss--new-survey/582447Most care home residents have both dementia and hearing loss, which can leave them feeling lonely and depressed.

Hearing loss and dementia both cause difficulties with listening, understanding and communicating. This can lead to breakdowns in relationships because something as simple as a conversation with a loved one can become impossible.

People with dementia often don’t know, or can’t communicate, that they have problems with their hearing. This means that a lot of the time, their carers don’t know either.

Crucially, many people with dementia, and especially those living in care homes, rely on carers to support their hearing needs. This might mean helping with hearing aids or other hearing devices, using communication techniques, writing things down or using flashcards and making sure background noise isn’t too loud.

When hearing care is given properly it can improve residents’ , mood and engagement with peers. Unfortunately, in a new study, my colleagues and I found that only of residents with dementia in UK care homes are given help with their hearing loss.

Poorly supported hearing loss leaves residents at risk of emotional and behavioural problems, worsened confusion and difficulties communicating with important people in their life like family, friends, carers and healthcare professionals. In the same study, just 27% of care staff said that they check that residents’ hearing aids are working properly. This is a huge problem as most residents with dementia aren’t able to do this themselves.

Complicated reasons

The survey results also revealed that the reasons residents with dementia aren’t receiving help with their hearing are complicated. The biggest problem in care homes appears to be access to resources, such as enough time, enough staff or enough things like hearing aid batteries or flashcards. Staff who completed the survey said that not enough resources in the care homes made it difficult to provide hearing-related care to residents with dementia.

Another part of the problem is that care staff don’t always have the relevant knowledge and skills to help residents with their hearing problems. Just under 25% of staff reported having had any training on hearing loss (despite over of residents having hearing loss), but almost all said that they wanted this training to be provided.

Hearing loss isn’t always prioritised in care homes. Compared to dehydration, infections or injuries, hearing and communication problems don’t cause immediate risk or physical harm to residents. So helping residents to hear well isn’t often a priority for staff, who have limited time and a heavy workload. That doesn’t mean that hearing and communicating aren’t essential for a person’s wellbeing and happiness.

Hearing loss isn’t always prioritised.

Results from our survey show that people with dementia living in care homes are not getting the care that they need and deserve to help them to hear, understand and communicate. Care home residents are often very vulnerable, and being able to hear well is essential to maintaining a good quality of life and engaging with .The Conversation

, Postdoctoral Research Associate,

This article is republished from under a Creative Commons license. Read the .

]]>
Tue, 25 Jul 2023 22:20:30 +0100 https://content.presspage.com/uploads/1369/500_hearing-impaired.jpg?10000 https://content.presspage.com/uploads/1369/hearing-impaired.jpg?10000
The mental health impact on ambulance staff of responding to suicide calls /about/news/the-mental-health-impact-on-ambulance-staff-of-responding-to-suicide-calls/ /about/news/the-mental-health-impact-on-ambulance-staff-of-responding-to-suicide-calls/395359 Ambulance staff are often the first to attend the site of many difficult scenes.

Being ambulance staff can be a high-stress job. They encounter many situations in their daily line of work that can have a lasting impact on their mental health. According to MIND, around have experienced poor mental health at some point in their career. Another study estimated that around have post-traumatic stress disorder (PTSD).

Ambulance staff are often the first to attend the site of many difficult scenes, including deaths by suicide. We interviewed ambulance staff about the impact that has on their mental health. We found that not only did many feel ill-equipped to respond to these calls, these events also had a severe impact on their mental health.

Lasting impact

We carried out interviews with nine ambulance staff. They had all lost at least one colleague to suicide, and said that responding to suicide was a common part of their job. They described often being the first professionals at the scene of a suicide or attempted suicide, and how they undertook varied – and often conflicting – roles.

This often involved negotiating with people in crisis, informing families and friends of the death of a loved one, dealing with the intense emotional reactions of bereaved people, and protecting the site and the body of the deceased until police arrive to investigate the scene of the death.

Participants reported intense memories of these events even if the suicide was some time ago. One participant told us:

I wouldn’t believe anybody […] if they said that it didn’t affect them because it always affects you… I’ll go to bed and I’ll dream about it and I’ll have strange dreams and I’ll think about it… [suicide] affects you mentally in some other way whether you think that you’re over it or not.

All ambulance staff interviewed also said that the impact of attending a suicide did not seem to be recognised by their managers and they had received no guidance about how to cope.

Many said they felt pressure to continue working, because stress and trauma are “what the job’s all about”. Others felt there was a stigma in asking for help. Ambulance staff also told us there was little guidance on how to respond to suicides, or how to care for staff who may have been affected.

Many ambulance staff felt there was a stigma in asking for help.

Research shows the job puts a heavy toll on ambulance staff, with mental health issues widespread. One that 14% of respondents reported symptoms of depression, 28% had symptoms of anxiety, and 34% appeared to be high risk for suicide. Another study found that in emergency services personnel than other professionals. Paramedics also experience the compared to other emergency service personnel. But our exploratory study is the first to examine the reasons why these mental health issues might be prevalent in this group.

Wider issue

The participants in our study also reported they had no training in how to respond to suicides, or how to support people at the scene who were bereaved by suicide. Their lack of training made them feel helpless, they said, especially given that these calls are a common part of the job.

This lack of training isn’t a unique issue among healthcare professionals of all kinds, who are often faced with situations they aren’t prepared or trained for. One of our study’s authors previously conducted interviews with GPs to find out what when dealing with parents bereaved by the suicide of adult children. The study found that many GPs also felt they hadn’t received sufficient training, and don’t have enough support in their practices to deal with this incredibly difficult part of their job.

As a result of our work, for health and social care professionals about how to respond to people bereaved by suicide. This training is the first of its kind internationally, and involves increasing knowledge, skills and confidence in responding to the bereaved at the scene of deaths by suicide.

This training is also available for ambulance staff. But our study showed that ambulance staff have different emotional, practical and training needs compared to GPs and other mental health professionals. Part of this is because ambulance staff tend to be the first professional on site, which means they are exposed to both the scene of the suicide and the bereaved families. The current training programme gives training on responding to the bereaved family, but doesn’t currently focus on issues around trauma, managing the incident or balancing conflicting roles during a call.

There is still a need for better awareness by the general public of how to talk about suicide and how to help those struggling to help prevent these unnecessary deaths. Opening a dialogue about suicide and the impact that it can have may help reduce stigma in the future and allow those who most need help to be able to receive it.


If you have seriously harmed yourself, or you don’t feel that you can keep yourself safe right now seek immediate help by calling 999.

If you are experiencing suicidal thoughts and need support, you can also call your GP, NHS 111 or Direct, or a free helpline such as (116 123), , or (0800 068 4141).The Conversation

, Professor of General Practice Research, Director of Clinical Academic Training, ; , Research fellow, , and , Honorary research fellow,

This article is republished from under a Creative Commons license. Read the .

]]>
Wed, 01 Jul 2020 13:56:33 +0100 https://content.presspage.com/uploads/1369/500_ambulance-1442004.jpg?10000 https://content.presspage.com/uploads/1369/ambulance-1442004.jpg?10000